Beta-arrestin-2 - GPRC6 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPRC6 73.3
Beta-arrestin-2 77.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 K 683 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 K 683 3x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 K 683 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic H8 F 849 8x54 s5s6 L 74 N.s5s6.10
Van-der-waals H8 F 849 8x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 A 687 3x57 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 687 3x57 s5s6 L 69 N.s5s6.05
Polar H8 K 846 8x51 S6 R 77 N.S6.02
Ionic H8 K 851 8x56 s17s18 E 314 C.s17s18.39
Polar H8 K 851 8x56 s17s18 E 314 C.s17s18.39
Van-der-waals H8 K 851 8x56 s17s18 E 314 C.s17s18.39
Hydrophobic TM3 F 688 3x58 s5s6 L 69 N.s5s6.05
Polar C-term Y 854 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term Y 854 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term Y 854 - s15s16 T 247 C.s15s16.05
Hydrophobic TM3 L 686 3x56 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 L 686 3x56 s5s6 D 68 N.s5s6.04
Hydrophobic C-term I 853 - s15s16 F 245 C.s15s16.03
Van-der-waals C-term I 853 - s15s16 F 245 C.s15s16.03
Hydrophobic TM2 G 628 2x34 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 G 628 2x34 s5s6 L 72 N.s5s6.08
Polar C-term Y 854 - s15s16 S 246 C.s15s16.04
Hydrophobic C-term Y 854 - s15s16 S 246 C.s15s16.04
Van-der-waals C-term Y 854 - s15s16 S 246 C.s15s16.04
Hydrophobic H8 L 850 8x55 s15s16 F 245 C.s15s16.03
Van-der-waals H8 L 850 8x55 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 K 683 3x53 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 K 683 3x53 s5s6 L 72 N.s5s6.08
Polar ICL2 F 690 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 F 690 - s5s6 R 66 N.s5s6.02
Hydrophobic C-term S 857 - s15s16 S 246 C.s15s16.04
Van-der-waals C-term S 857 - s15s16 S 246 C.s15s16.04
Hydrophobic TM3 F 688 3x58 s8s9 K 139 N.s8s9.09
Hydrophobic ICL1 S 627 12x53 s5s6 L 72 N.s5s6.08
Polar C-term S 858 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term S 858 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term S 858 - s15s16 T 247 C.s15s16.05
Polar ICL2 Q 695 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 Q 695 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 Q 695 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 F 690 - S5 Y 64 N.S5.12
Van-der-waals ICL2 F 690 - S5 Y 64 N.S5.12
Hydrophobic ICL2 P 692 - s8s9 P 134 N.s8s9.04
Van-der-waals ICL2 P 692 - s8s9 P 134 N.s8s9.04
Hydrophobic C-term I 864 - s8s9 T 137 N.s8s9.07
Van-der-waals C-term I 864 - s8s9 T 137 N.s8s9.07
Polar C-term Y 854 - S15 I 242 C.S15.14
Polar C-term S 857 - s15s16 F 245 C.s15s16.03
Van-der-waals C-term S 857 - s15s16 F 245 C.s15s16.03
Polar ICL2 S 689 - s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 S 689 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 S 689 - s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 F 690 - s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 F 690 - s8s9 G 138 N.s8s9.08
Polar C-term Y 854 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term Y 854 - s15s16 F 245 C.s15s16.03
Van-der-waals C-term Y 854 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term Y 854 - s15s16 L 244 C.s15s16.02
Ionic ICL2 K 696 - s20c D 402 C.s20c.12
Polar ICL2 K 696 - s20c D 402 C.s20c.12
Hydrophobic ICL2 K 696 - s20c D 402 C.s20c.12
Van-der-waals ICL2 K 696 - s20c D 402 C.s20c.12
Polar ICL2 P 692 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 692 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 692 - s5s6 R 66 N.s5s6.02
Hydrophobic C-term I 853 - s5s6 L 74 N.s5s6.10
Van-der-waals C-term I 853 - s5s6 L 74 N.s5s6.10
Hydrophobic C-term I 853 - S6 F 76 N.S6.01
Van-der-waals C-term I 853 - S6 F 76 N.S6.01
Hydrophobic ICL1 S 626 12x52 s5s6 L 72 N.s5s6.08
Van-der-waals ICL1 S 626 12x52 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 F 690 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 F 690 - s8s9 T 137 N.s8s9.07
Polar ICL2 D 691 - s5s6 R 66 N.s5s6.02
Polar TM3 A 687 3x57 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 A 687 3x57 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 A 687 3x57 s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 F 690 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 F 690 - s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 K 696 - s20c Y 404 C.s20c.14
Van-der-waals ICL2 K 696 - s20c Y 404 C.s20c.14
Ionic ICL2 K 699 - s5s6 E 67 N.s5s6.03
Polar ICL2 K 699 - s5s6 E 67 N.s5s6.03
Van-der-waals ICL2 K 699 - s5s6 E 67 N.s5s6.03
Hydrophobic C-term V 861 - S16 A 248 C.S16.01
Hydrophobic H8 L 850 8x55 S6 F 76 N.S6.01
Van-der-waals H8 L 850 8x55 S6 F 76 N.S6.01
Polar C-term Y 854 - s15s16 C 243 C.s15s16.01
Hydrophobic C-term Y 854 - s15s16 C 243 C.s15s16.01
Van-der-waals C-term Y 854 - s15s16 C 243 C.s15s16.01
Hydrophobic TM3 I 684 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 S 626 12x52 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 K 680 3x50 s5s6 L 72 N.s5s6.08
Polar TM3 K 683 3x53 s5s6 D 70 N.s5s6.06
Van-der-waals TM3 K 683 3x53 s5s6 D 70 N.s5s6.06
Ionic ICL2 K 699 - s5s6 D 68 N.s5s6.04
Polar ICL2 K 699 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 K 699 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 K 699 - s5s6 D 68 N.s5s6.04
Hydrophobic H8 F 849 8x54 S6 F 76 N.S6.01
Hydrophobic ICL1 K 625 12x51 s5s6 L 72 N.s5s6.08
Van-der-waals ICL1 K 625 12x51 s5s6 L 72 N.s5s6.08
Hydrophobic C-term M 880 - s18s19 R 332 C.s18s19.02
Hydrophobic C-term S 858 - s15s16 S 246 C.s15s16.04
Polar ICL2 Q 695 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Q 695 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 695 - s5s6 R 66 N.s5s6.02
Polar ICL2 Q 695 - s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 Q 695 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 Q 695 - s8s9 K 139 N.s8s9.09
Polar TM3 L 686 3x56 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 L 686 3x56 s8s9 K 139 N.s8s9.09