ArrestinDb

Arrestin-C - GPRC6 receptor complex model

Full

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
GPRC6	73.4
Arrestin-C	79.4

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.3

PAE mean: 23.4

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	H8	F	849	8x54	s5s6	L	69	N.s5s6.10
Hydrophobic	TM3	F	688	3x58	S6	F	71	N.S6.01
Hydrophobic	ICL2	Q	695	-	s8s9	K	135	N.s8s9.09
Hydrophobic	C-term	Y	854	-	s17s18	D	308	C.s17s18.37
Hydrophobic	C-term	V	861	-	s15s16	L	243	C.s15s16.05
Hydrophobic	TM3	A	687	3x57	s5s6	I	67	N.s5s6.08
Hydrophobic	C-term	Y	854	-	s15s16	L	240	C.s15s16.02
Hydrophobic	TM4	Y	702	4x30	s5s6	V	66	N.s5s6.07
Hydrophobic	C-term	Y	854	-	S6	K	73	N.S6.03
Hydrophobic	C-term	V	861	-	s15s16	V	239	C.s15s16.01
Hydrophobic	TM3	K	683	3x53	s5s6	V	66	N.s5s6.07
Hydrophobic	C-term	I	853	-	s15s16	Y	241	C.s15s16.03
Hydrophobic	C-term	I	853	-	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL3	Y	778	-	s5s6	L	69	N.s5s6.10
Hydrophobic	TM4	P	704	4x32	s5s6	V	66	N.s5s6.07
Hydrophobic	TM3	I	684	3x54	s5s6	I	67	N.s5s6.08
Hydrophobic	ICL2	F	690	-	s15s16	S	242	C.s15s16.04
Hydrophobic	C-term	S	857	-	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL2	P	692	-	S16	D	244	C.S16.01
Hydrophobic	ICL2	P	692	-	s8s9	G	134	N.s8s9.08
Hydrophobic	ICL2	K	699	-	s8s9	K	135	N.s8s9.09
Hydrophobic	C-term	S	858	-	s17s18	E	310	C.s17s18.39
Hydrophobic	ICL2	K	693	-	s8s9	A	133	N.s8s9.07
Hydrophobic	ICL2	F	690	-	s15s16	Y	241	C.s15s16.03
Hydrophobic	C-term	S	860	-	s15s16	L	243	C.s15s16.05
Hydrophobic	ICL2	P	692	-	s8s9	A	133	N.s8s9.07
Hydrophobic	ICL2	Q	695	-	S5	Y	59	N.S5.12
Hydrophobic	ICL2	K	699	-	s5s6	D	63	N.s5s6.04
Hydrophobic	C-term	Y	854	-	s17s18	L	311	C.s17s18.40
Hydrophobic	ICL2	K	699	-	s5s6	R	61	N.s5s6.02
Hydrophobic	ICL2	F	690	-	S16	D	244	C.S16.01
Hydrophobic	C-term	Y	854	-	s17s18	E	310	C.s17s18.39
Hydrophobic	TM3	L	686	3x56	s5s6	R	61	N.s5s6.02
Hydrophobic	C-term	I	864	-	s15s16	L	243	C.s15s16.05
Hydrophobic	TM3	L	686	3x56	s5s6	D	63	N.s5s6.04
Hydrophobic	TM3	L	686	3x56	s5s6	L	64	N.s5s6.05
Hydrophobic	ICL2	Q	695	-	s5s6	R	61	N.s5s6.02
Hydrophobic	C-term	V	861	-	s17s18	E	310	C.s17s18.39
Hydrophobic	ICL1	S	626	12x52	s5s6	L	69	N.s5s6.10
Hydrophobic	TM4	Y	702	4x30	s5s6	D	63	N.s5s6.04
Hydrophobic	ICL2	K	696	-	s8s9	K	135	N.s8s9.09
Hydrophobic	C-term	S	857	-	s15s16	L	240	C.s15s16.02
Hydrophobic	TM3	K	683	3x53	s5s6	I	67	N.s5s6.08
Hydrophobic	H8	L	850	8x55	S6	K	73	N.S6.03
Hydrophobic	TM3	A	687	3x57	S6	F	71	N.S6.01
Hydrophobic	TM3	A	687	3x57	s5s6	L	64	N.s5s6.05
Ionic	ICL2	K	699	-	s5s6	D	63	N.s5s6.04
Ionic	ICL2	K	699	-	s5s6	D	62	N.s5s6.03
Ionic	H8	K	846	8x51	S6	D	74	N.S6.04
Polar	ICL2	Q	695	-	s8s9	K	135	N.s8s9.09
Polar	C-term	Y	854	-	s17s18	D	308	C.s17s18.37
Polar	TM3	K	683	3x53	s5s6	V	66	N.s5s6.07
Polar	ICL2	S	689	-	s5s6	R	61	N.s5s6.02
Polar	C-term	S	857	-	s15s16	Y	241	C.s15s16.03
Polar	C-term	S	858	-	s17s18	E	310	C.s17s18.39
Polar	ICL2	K	693	-	s8s9	A	133	N.s8s9.07
Polar	ICL2	Q	695	-	S5	Y	59	N.S5.12
Polar	ICL2	K	699	-	s5s6	D	63	N.s5s6.04
Polar	C-term	Y	854	-	s17s18	L	311	C.s17s18.40
Polar	C-term	Y	854	-	s17s18	E	310	C.s17s18.39
Polar	TM3	L	686	3x56	s5s6	R	61	N.s5s6.02
Polar	ICL2	K	699	-	s5s6	G	60	N.s5s6.01
Polar	ICL2	K	699	-	s5s6	D	62	N.s5s6.03
Polar	ICL2	Q	695	-	s5s6	R	61	N.s5s6.02
Polar	TM3	K	683	3x53	s5s6	I	67	N.s5s6.08
Polar	H8	K	846	8x51	S6	D	74	N.S6.04
Van-der-waals	H8	F	849	8x54	s5s6	L	69	N.s5s6.10
Van-der-waals	ICL2	Q	695	-	s8s9	K	135	N.s8s9.09
Van-der-waals	C-term	Y	854	-	s17s18	D	308	C.s17s18.37
Van-der-waals	C-term	V	861	-	s15s16	L	243	C.s15s16.05
Van-der-waals	TM3	A	687	3x57	s5s6	I	67	N.s5s6.08
Van-der-waals	TM4	Y	702	4x30	s5s6	V	66	N.s5s6.07
Van-der-waals	C-term	Y	854	-	S6	K	73	N.S6.03
Van-der-waals	C-term	V	861	-	s15s16	V	239	C.s15s16.01
Van-der-waals	TM3	K	683	3x53	s5s6	V	66	N.s5s6.07
Van-der-waals	ICL2	S	689	-	s5s6	R	61	N.s5s6.02
Van-der-waals	C-term	I	853	-	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL2	F	690	-	s15s16	S	242	C.s15s16.04
Van-der-waals	C-term	S	857	-	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL2	P	692	-	S16	D	244	C.S16.01
Van-der-waals	ICL2	P	692	-	s8s9	G	134	N.s8s9.08
Van-der-waals	ICL2	K	699	-	s8s9	K	135	N.s8s9.09
Van-der-waals	C-term	S	858	-	s17s18	E	310	C.s17s18.39
Van-der-waals	ICL2	K	693	-	s8s9	A	133	N.s8s9.07
Van-der-waals	ICL2	F	690	-	s15s16	Y	241	C.s15s16.03
Van-der-waals	C-term	S	860	-	s15s16	L	243	C.s15s16.05
Van-der-waals	ICL2	P	692	-	s8s9	A	133	N.s8s9.07
Van-der-waals	ICL2	Q	695	-	S5	Y	59	N.S5.12
Van-der-waals	ICL2	K	699	-	s5s6	D	63	N.s5s6.04
Van-der-waals	C-term	Y	854	-	s17s18	L	311	C.s17s18.40
Van-der-waals	ICL2	K	699	-	s5s6	R	61	N.s5s6.02
Van-der-waals	ICL2	F	690	-	S16	D	244	C.S16.01
Van-der-waals	C-term	Y	854	-	s17s18	E	310	C.s17s18.39
Van-der-waals	TM3	L	686	3x56	s5s6	R	61	N.s5s6.02
Van-der-waals	ICL2	K	699	-	s5s6	G	60	N.s5s6.01
Van-der-waals	ICL2	K	699	-	s5s6	D	62	N.s5s6.03
Van-der-waals	C-term	I	864	-	s15s16	L	243	C.s15s16.05
Van-der-waals	TM3	L	686	3x56	s5s6	D	63	N.s5s6.04
Van-der-waals	ICL2	Q	695	-	s5s6	R	61	N.s5s6.02
Van-der-waals	TM3	K	683	3x53	s5s6	I	67	N.s5s6.08
Van-der-waals	H8	K	846	8x51	S6	D	74	N.S6.04
Van-der-waals	H8	L	850	8x55	S6	K	73	N.S6.03
Van-der-waals	TM3	A	687	3x57	S6	F	71	N.S6.01
Van-der-waals	TM3	A	687	3x57	s5s6	L	64	N.s5s6.05

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Main reference

Arrestin-C - GPRC6 receptor complex model Download Full