Beta-arrestin-2 - GPR12 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR12 74.9
Beta-arrestin-2 79.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 L 142 3x54 S5 Y 64 N.S5.12
Hydrophobic TM3 L 142 3x54 S5 Y 64 N.S5.12
Van-der-waals TM3 L 142 3x54 S5 Y 64 N.S5.12
Polar ICL2 T 147 34x52 S16 Y 250 C.S16.03
Hydrophobic ICL2 T 147 34x52 S16 Y 250 C.S16.03
Hydrophobic TM5 I 231 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 I 231 5x72 S6 K 78 N.S6.03
Hydrophobic ICL2 L 146 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 146 34x51 S15 I 242 C.S15.14
Polar ICL2 A 145 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 A 145 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 A 145 34x50 S5 Y 64 N.S5.12
Polar TM5 Q 230 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 Q 230 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 Q 230 5x71 s17s18 E 314 C.s17s18.39
Polar H8 Q 306 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 H 242 6x26 S6 K 78 N.S6.03
Polar H8 E 307 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 H 149 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 H 149 - s8s9 E 135 N.s8s9.05
Hydrophobic TM3 L 142 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 L 142 3x54 S6 F 76 N.S6.01
Hydrophobic TM3 R 138 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 138 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 253 6x37 s5s6 L 74 N.s5s6.10
Polar ICL1 S 74 12x49 s20c Y 404 C.s20c.14
Ionic ICL2 H 149 - s8s9 D 136 N.s8s9.06
Polar ICL2 H 149 - s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 H 149 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 H 149 - s8s9 D 136 N.s8s9.06
Polar TM5 H 227 5x68 S6 K 78 N.S6.03
Hydrophobic ICL3 L 238 - S6 L 80 N.S6.05
Van-der-waals ICL3 L 238 - S6 L 80 N.S6.05
Hydrophobic ICL2 A 145 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic TM5 H 227 5x68 s15s16 L 244 C.s15s16.02
Ionic TM6 H 242 6x26 S6 D 79 N.S6.04
Polar TM6 H 242 6x26 S6 D 79 N.S6.04
Hydrophobic TM6 H 242 6x26 S6 D 79 N.S6.04
Van-der-waals TM6 H 242 6x26 S6 D 79 N.S6.04
Hydrophobic TM6 G 249 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 L 253 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 253 6x37 s5s6 L 72 N.s5s6.08
Polar TM5 Q 230 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 Q 230 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 Q 230 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 I 220 5x61 s5s6 L 74 N.s5s6.10
Polar ICL3 F 237 - S6 I 82 N.S6.07
Hydrophobic TM6 T 252 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 252 6x36 s5s6 L 72 N.s5s6.08
Polar TM3 Y 143 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 Y 143 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 Y 143 3x55 s15s16 S 246 C.s15s16.04
Aromatic H8 K 310 8x52 s20c Y 404 C.s20c.14
Hydrophobic H8 K 310 8x52 s20c Y 404 C.s20c.14
Van-der-waals H8 K 310 8x52 s20c Y 404 C.s20c.14
Hydrophobic TM3 L 142 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 142 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 L 146 34x51 S5 Y 64 N.S5.12
Hydrophobic TM5 I 220 5x61 S6 F 76 N.S6.01
Hydrophobic ICL2 L 146 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 L 146 34x51 S9 C 141 N.S9.01
Polar TM7 R 304 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 R 304 7x56 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 R 304 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 Q 234 5x75 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 Q 234 5x75 s17s18 V 315 C.s17s18.40
Hydrophobic TM6 G 249 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 G 249 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 Y 217 5x58 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 Y 217 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 M 79 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM5 I 231 5x72 S6 D 79 N.S6.04
Hydrophobic TM2 M 79 2x39 s5s6 D 68 N.s5s6.04
Polar ICL2 H 149 - s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 H 149 - s17s18 R 286 C.s17s18.11
Hydrophobic TM5 I 223 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 V 224 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 V 224 5x65 S6 F 76 N.S6.01
Hydrophobic TM6 I 256 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 256 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 V 224 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 L 238 - S6 D 79 N.S6.04
Van-der-waals ICL3 L 238 - S6 D 79 N.S6.04
Hydrophobic TM7 I 300 7x52 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 I 300 7x52 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 138 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 138 3x50 s5s6 L 72 N.s5s6.08
Polar ICL2 Y 148 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Y 148 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 148 34x53 s5s6 R 66 N.s5s6.02
Polar TM5 H 227 5x68 s15s16 F 245 C.s15s16.03
Aromatic TM5 H 227 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 227 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 227 5x68 s15s16 F 245 C.s15s16.03
Aromatic ICL3 F 237 - S6 F 81 N.S6.06
Hydrophobic ICL3 F 237 - S6 F 81 N.S6.06
Van-der-waals ICL3 F 237 - S6 F 81 N.S6.06
Hydrophobic ICL2 L 146 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 146 34x51 S16 Y 250 C.S16.03
Hydrophobic TM3 S 141 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 S 141 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 H 149 - s5s6 R 66 N.s5s6.02
Aromatic ICL2 H 149 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 H 149 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 H 149 - s5s6 R 66 N.s5s6.02
Polar TM6 H 242 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 H 242 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 H 242 6x26 S6 R 77 N.S6.02
Hydrophobic ICL3 F 237 - s7s8 P 121 N.s7s8.03
Van-der-waals ICL3 F 237 - s7s8 P 121 N.s7s8.03
Hydrophobic ICL2 L 146 34x51 S8 L 130 N.S8.03
Polar TM5 Q 234 5x75 s17s18 N 312 C.s17s18.37
Hydrophobic TM5 Q 234 5x75 s17s18 N 312 C.s17s18.37
Van-der-waals TM5 Q 234 5x75 s17s18 N 312 C.s17s18.37