Beta-arrestin-1 - GPR17 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR17 72.7
Beta-arrestin-1 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 164 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 L 247 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL3 V 253 - S6 F 75 N.S6.01
Van-der-waals ICL3 V 253 - S6 F 75 N.S6.01
Hydrophobic C-term T 356 - s20c N 417 C.s20c.27
Van-der-waals C-term T 356 - s20c N 417 C.s20c.27
Van-der-waals ICL2 L 168 34x54 S5 Y 63 N.S5.12
Hydrophobic C-term S 359 - s20c R 418 C.s20c.28
Van-der-waals C-term S 359 - s20c R 418 C.s20c.28
Van-der-waals TM3 R 157 3x50 s5s6 V 70 N.s5s6.07
Ionic ICL3 R 252 - s17s18 E 313 C.s17s18.39
Polar ICL3 R 252 - s17s18 E 313 C.s17s18.39
Van-der-waals ICL3 R 252 - s17s18 E 313 C.s17s18.39
Polar ICL3 R 252 - S6 K 77 N.S6.03
Hydrophobic ICL3 R 252 - S6 K 77 N.S6.03
Hydrophobic ICL3 V 253 - s5s6 L 73 N.s5s6.10
Polar ICL2 P 164 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 164 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 164 34x50 S5 Y 63 N.S5.12
Ionic TM4 R 172 4x38 s8s9 E 134 N.s8s9.05
Polar TM4 R 172 4x38 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 R 172 4x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 R 172 4x38 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 M 264 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 M 264 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 A 160 3x53 s5s6 L 68 N.s5s6.05
Polar ICL2 V 165 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 V 165 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 V 165 34x51 S5 Y 63 N.S5.12
Polar ICL2 V 165 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 V 165 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 V 165 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 168 34x54 S16 Y 249 C.S16.03
Hydrophobic TM6 M 264 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 264 6x36 s5s6 L 71 N.s5s6.08
Ionic H8 H 334 8x52 s20c E 407 C.s20c.17
Polar H8 H 334 8x52 s20c E 407 C.s20c.17
Hydrophobic H8 H 334 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 H 334 8x52 s20c E 407 C.s20c.17
Hydrophobic ICL3 R 252 - s15s16 L 243 C.s15s16.02
Van-der-waals ICL3 R 252 - s15s16 L 243 C.s15s16.02
Polar C-term N 357 - s20c R 418 C.s20c.28
Hydrophobic C-term N 357 - s20c R 418 C.s20c.28
Van-der-waals C-term N 357 - s20c R 418 C.s20c.28
Hydrophobic ICL2 V 165 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 V 165 34x51 S15 I 241 C.S15.14
Polar ICL3 V 253 - S6 R 76 N.S6.02
Polar C-term K 355 - s20c R 418 C.s20c.28
Van-der-waals C-term K 355 - s20c R 418 C.s20c.28
Polar TM3 H 163 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 H 163 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 H 163 3x56 s15s16 N 245 C.s15s16.04
Polar ICL3 R 252 - S6 R 76 N.S6.02
Hydrophobic ICL3 R 252 - S6 R 76 N.S6.02
Van-der-waals ICL3 R 252 - S6 R 76 N.S6.02
Hydrophobic TM2 P 93 2x38 s5s6 R 65 N.s5s6.02
Ionic ICL1 K 89 - s20c D 402 C.s20c.12
Polar ICL1 K 89 - s20c D 402 C.s20c.12
Van-der-waals ICL1 K 89 - s20c D 402 C.s20c.12
Aromatic ICL3 R 252 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 R 252 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 R 252 - s15s16 F 244 C.s15s16.03
Van-der-waals TM6 L 257 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 A 261 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 L 98 2x43 s5s6 V 70 N.s5s6.07
Ionic ICL1 K 89 - s20c E 404 C.s20c.14
Polar ICL1 K 89 - s20c E 404 C.s20c.14
Hydrophobic ICL1 K 89 - s20c E 404 C.s20c.14
Van-der-waals ICL1 K 89 - s20c E 404 C.s20c.14
Hydrophobic ICL2 V 165 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 168 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 L 168 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic TM7 M 324 7x52 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 M 324 7x52 s5s6 V 70 N.s5s6.07
Polar ICL1 G 91 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 G 91 - s8s9 T 136 N.s8s9.07
Polar ICL1 G 91 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL1 G 91 - s5s6 R 65 N.s5s6.02
Hydrophobic TM7 Y 325 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 161 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 161 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 168 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 L 168 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic TM6 A 261 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 261 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 161 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 161 3x54 S6 F 75 N.S6.01
Polar ICL2 K 166 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 K 166 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 K 166 34x52 s15s16 N 245 C.s15s16.04
Ionic H8 K 331 8x49 s5s6 D 67 N.s5s6.04
Polar H8 K 331 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 K 331 8x49 s5s6 D 67 N.s5s6.04
Ionic TM4 R 172 4x38 s8s9 D 135 N.s8s9.06
Polar TM4 R 172 4x38 s8s9 D 135 N.s8s9.06
Hydrophobic TM4 R 172 4x38 s8s9 D 135 N.s8s9.06
Van-der-waals TM4 R 172 4x38 s8s9 D 135 N.s8s9.06
Hydrophobic C-term T 356 - s20c R 418 C.s20c.28
Hydrophobic H8 A 329 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 I 265 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 265 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 V 165 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 V 165 34x51 S16 A 247 C.S16.01
Ionic TM3 R 157 3x50 s5s6 D 69 N.s5s6.06
Polar TM3 R 157 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 157 3x50 s5s6 D 69 N.s5s6.06
Van-der-waals TM3 R 157 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 164 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 164 34x50 s15s16 N 245 C.s15s16.04
Polar TM3 A 160 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM3 A 160 3x53 s8s9 K 138 N.s8s9.09
Van-der-waals TM3 A 160 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM6 L 257 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 K 260 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 T 92 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 T 92 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 161 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 247 5x65 S6 F 75 N.S6.01
Hydrophobic TM2 T 92 2x37 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 T 92 2x37 s5s6 R 65 N.s5s6.02
Polar ICL2 R 171 34x57 s5s6 R 65 N.s5s6.02