Arrestin-C - GPR17 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR17 71.7
Arrestin-C 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 92 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 92 2x37 s5s6 D 63 N.s5s6.04
Polar TM6 K 260 6x32 s5s6 E 65 N.s5s6.06
Van-der-waals TM6 K 260 6x32 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 P 93 2x38 s5s6 D 63 N.s5s6.04
Polar ICL2 K 169 34x55 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 K 169 34x55 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 K 169 34x55 s15s16 L 243 C.s15s16.05
Hydrophobic ICL3 V 253 - s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 168 34x54 s15s16 Y 241 C.s15s16.03
Polar ICL2 L 168 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 L 168 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 L 168 34x54 s5s6 R 61 N.s5s6.02
Ionic ICL2 K 169 34x55 S16 D 244 C.S16.01
Hydrophobic ICL2 K 169 34x55 S16 D 244 C.S16.01
Van-der-waals ICL2 K 169 34x55 S16 D 244 C.S16.01
Hydrophobic TM6 L 257 6x29 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 L 257 6x29 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 M 264 6x36 s5s6 I 67 N.s5s6.08
Ionic ICL1 K 89 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL2 L 168 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 168 34x54 S5 Y 59 N.S5.12
Hydrophobic ICL3 R 252 - S6 V 77 N.S6.07
Van-der-waals ICL3 R 252 - S6 V 77 N.S6.07
Ionic C-term R 344 - s20c E 386 C.s20c.20
Polar C-term R 344 - s20c E 386 C.s20c.20
Van-der-waals C-term R 344 - s20c E 386 C.s20c.20
Ionic ICL3 R 252 - S6 D 74 N.S6.04
Polar ICL3 R 252 - S6 D 74 N.S6.04
Hydrophobic ICL3 R 252 - S6 D 74 N.S6.04
Van-der-waals ICL3 R 252 - S6 D 74 N.S6.04
Polar TM3 R 157 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 157 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 157 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 L 257 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 L 257 6x29 s5s6 T 70 N.s5s6.11
Polar TM6 K 255 6x27 s9s10 T 154 N.s9s10.09
Hydrophobic TM6 K 255 6x27 s9s10 T 154 N.s9s10.09
Hydrophobic ICL2 V 165 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 V 165 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 A 261 6x33 s5s6 L 69 N.s5s6.10
Polar ICL3 R 252 - S6 Y 76 N.S6.06
Hydrophobic ICL3 R 252 - S6 Y 76 N.S6.06
Van-der-waals ICL3 R 252 - S6 Y 76 N.S6.06
Hydrophobic ICL2 L 168 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 168 34x54 s15s16 S 242 C.s15s16.04
Ionic ICL2 R 171 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 171 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 171 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic C-term F 352 - s20c K 378 C.s20c.11
Van-der-waals C-term F 352 - s20c K 378 C.s20c.11
Polar ICL2 R 171 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 171 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 A 261 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM7 V 328 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 V 328 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 157 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 157 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic C-term L 361 - H1 K 104 N.H1.09
Hydrophobic TM6 K 260 6x32 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 K 260 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 P 164 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 P 164 34x50 S6 F 71 N.S6.01
Hydrophobic TM6 L 257 6x29 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 L 257 6x29 s5s6 G 68 N.s5s6.09
Polar H8 E 330 8x48 s5s6 G 68 N.s5s6.09
Hydrophobic H8 E 330 8x48 s5s6 G 68 N.s5s6.09
Van-der-waals H8 E 330 8x48 s5s6 G 68 N.s5s6.09
Polar TM6 K 260 6x32 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 K 260 6x32 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 K 260 6x32 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 A 160 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 A 160 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 I 161 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 161 3x54 s5s6 I 67 N.s5s6.08
Polar H8 E 330 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 E 330 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 E 330 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 A 94 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 A 94 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 I 161 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 161 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 P 164 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 164 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 K 260 6x32 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 K 260 6x32 s5s6 I 67 N.s5s6.08