S-arrestin - GPR18 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR18 76.6
S-arrestin 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic ICL2 K 127 34x51 S16 D 257 C.S16.01
Polar ICL2 K 127 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 K 127 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 K 127 34x51 S16 D 257 C.S16.01
Hydrophobic TM7 V 289 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 K 133 34x57 s5s6 I 76 N.s5s6.05
Van-der-waals ICL2 K 133 34x57 s5s6 I 76 N.s5s6.05
Hydrophobic TM6 K 229 6x32 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 K 229 6x32 s5s6 I 79 N.s5s6.08
Ionic TM6 K 223 6x26 S6 D 86 N.S6.04
Polar TM6 K 223 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 K 223 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 K 223 6x26 S6 D 86 N.S6.04
Hydrophobic TM3 I 123 3x54 S6 F 83 N.S6.01
Ionic H8 K 291 8x48 s5s6 D 77 N.s5s6.06
Polar H8 K 291 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 291 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 291 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 L 222 6x25 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 K 133 34x57 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 K 130 34x54 s8s9 S 143 N.s8s9.07
Ionic ICL1 K 53 - s20c E 395 C.s20c.14
Hydrophobic TM2 V 57 2x39 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 D 118 3x49 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 D 118 3x49 s5s6 V 78 N.s5s6.07
Polar ICL2 K 127 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 K 127 34x51 S5 Y 71 N.S5.12
Ionic TM6 K 221 6x24 s17s18 D 321 C.s17s18.37
Hydrophobic TM3 A 122 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 122 3x53 S6 F 83 N.S6.01
Hydrophobic TM2 T 55 2x37 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 K 127 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 K 130 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 K 130 34x54 s8s9 K 145 N.s8s9.09
Polar TM6 K 221 6x24 s17s18 T 323 C.s17s18.39
Hydrophobic TM6 K 229 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 229 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 P 126 34x50 s15s16 Y 254 C.s15s16.03
Polar ICL3 R 218 - s15s16 S 256 C.s15s16.05
Van-der-waals ICL3 R 218 - s15s16 S 256 C.s15s16.05
Hydrophobic TM2 V 57 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 V 57 2x39 s5s6 V 78 N.s5s6.07
Ionic ICL2 K 130 34x54 s8s9 D 142 N.s8s9.06
Polar ICL2 K 130 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 K 130 34x54 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 K 130 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic TM3 R 119 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 119 3x50 s5s6 I 79 N.s5s6.08
Polar ICL3 R 218 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL3 R 218 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 R 218 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 V 226 6x29 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 226 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 K 221 6x24 S6 R 85 N.S6.03
Van-der-waals TM6 K 221 6x24 S6 R 85 N.S6.03
Ionic TM6 K 225 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 K 225 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 K 225 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 K 225 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM3 I 123 3x54 s5s6 L 81 N.s5s6.10
Polar ICL3 R 218 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL3 R 218 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 K 130 34x54 s8s9 Q 141 N.s8s9.05
Polar ICL2 P 126 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 126 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 126 34x50 S5 Y 71 N.S5.12
Ionic ICL2 E 131 34x55 s8s9 K 145 N.s8s9.09
Polar ICL2 E 131 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 E 131 34x55 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 L 222 6x25 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 L 222 6x25 s15s16 Y 254 C.s15s16.03
Polar TM6 K 223 6x26 S6 R 84 N.S6.02
Hydrophobic TM6 K 223 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 K 223 6x26 S6 R 84 N.S6.02
Hydrophobic TM6 L 222 6x25 S6 F 83 N.S6.01
Van-der-waals TM6 L 222 6x25 S6 F 83 N.S6.01
Ionic ICL1 K 53 - s5s6 D 75 N.s5s6.04
Polar ICL1 K 53 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 K 53 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 K 53 - s5s6 D 75 N.s5s6.04
Ionic TM6 K 225 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 K 225 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 K 225 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 225 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 K 130 34x54 s8s9 G 144 N.s8s9.08
Van-der-waals ICL2 K 130 34x54 s8s9 G 144 N.s8s9.08
Hydrophobic ICL2 K 127 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 K 127 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic ICL1 K 53 - s20c R 398 C.s20c.17
Ionic TM6 K 223 6x26 s9s10 E 165 N.s9s10.07
Polar TM6 K 223 6x26 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 K 223 6x26 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 I 233 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 233 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 T 219 - s15s16 Y 254 C.s15s16.03