Beta-arrestin-2 - GPR19 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR19 63.8
Beta-arrestin-2 75.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals C-term K 398 - s17s18 K 313 C.s17s18.38
Ionic C-term R 395 - S15 D 241 C.S15.13
Polar C-term R 395 - S15 D 241 C.S15.13
Hydrophobic C-term R 395 - S15 D 241 C.S15.13
Van-der-waals C-term R 395 - S15 D 241 C.S15.13
Hydrophobic C-term M 380 - s7s8 N 123 N.s7s8.05
Hydrophobic TM6 T 270 6x29 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 270 6x29 s5s6 L 72 N.s5s6.08
Hydrophobic C-term Y 390 - S13 L 208 C.S13.01
Hydrophobic ICL3 R 262 - S6 K 78 N.S6.03
Van-der-waals ICL3 R 262 - S6 K 78 N.S6.03
Hydrophobic TM6 M 264 6x23 S6 F 76 N.S6.01
Van-der-waals TM6 M 264 6x23 S6 F 76 N.S6.01
Polar C-term Y 358 - s20c D 406 C.s20c.16
Hydrophobic C-term Y 358 - s20c D 406 C.s20c.16
Van-der-waals C-term Y 358 - s20c D 406 C.s20c.16
Hydrophobic C-term I 377 - s17s18 V 315 C.s17s18.40
Polar ICL2 P 170 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 170 34x50 S5 Y 64 N.S5.12
Hydrophobic C-term I 389 - s10s11 K 178 C.s10s11.04
Van-der-waals C-term I 389 - s10s11 K 178 C.s10s11.04
Polar ICL2 K 174 - s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 K 174 - s8s9 D 136 N.s8s9.06
Polar H8 R 339 8x52 s20c Q 407 C.s20c.17
Polar C-term F 393 - S18 S 321 C.S18.04
Van-der-waals C-term F 393 - S18 S 321 C.S18.04
Hydrophobic C-term M 380 - s17s18 A 311 C.s17s18.36
Ionic ICL1 R 95 12x49 s5s6 E 67 N.s5s6.03
Polar ICL1 R 95 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic C-term R 365 - s9s10 K 158 N.s9s10.09
Van-der-waals C-term R 365 - s9s10 K 158 N.s9s10.09
Polar ICL2 L 171 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 L 171 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 171 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic C-term F 393 - s17s18 V 307 C.s17s18.32
Hydrophobic TM3 T 166 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 T 166 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 T 263 6x22 S6 K 78 N.S6.03
Polar ICL2 P 170 34x50 s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 P 170 34x50 s8s9 K 139 N.s8s9.09
Hydrophobic TM6 T 263 6x22 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 T 263 6x22 s15s16 F 245 C.s15s16.03
Polar C-term D 391 - s17s18 V 307 C.s17s18.32
Van-der-waals C-term D 391 - s17s18 V 307 C.s17s18.32
Polar C-term W 404 - s17s18 E 314 C.s17s18.39
Hydrophobic C-term W 404 - s17s18 E 314 C.s17s18.39
Van-der-waals C-term W 404 - s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 L 171 34x51 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 L 171 34x51 s15s16 F 245 C.s15s16.03
Hydrophobic C-term I 374 - S6 I 82 N.S6.07
Van-der-waals C-term I 374 - S6 I 82 N.S6.07
Polar C-term Y 371 - S6 D 79 N.S6.04
Hydrophobic C-term Y 371 - S6 D 79 N.S6.04
Van-der-waals C-term Y 371 - S6 D 79 N.S6.04
Hydrophobic TM2 T 100 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 T 100 2x39 s5s6 L 72 N.s5s6.08
Polar C-term F 414 - S15 R 237 C.S15.09
Polar C-term F 393 - s17s18 T 305 C.s17s18.30
Hydrophobic C-term S 392 - s17s18 V 307 C.s17s18.32
Polar TM6 K 271 6x30 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 K 271 6x30 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 K 271 6x30 s5s6 L 72 N.s5s6.08
Polar C-term Y 358 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term Y 358 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term Y 358 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term I 374 - S6 F 81 N.S6.06
Ionic TM4 R 177 4x39 s5s6 D 68 N.s5s6.04
Polar C-term I 406 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term I 406 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term I 406 - s15s16 T 247 C.s15s16.05
Polar TM6 T 270 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 T 270 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 T 270 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic C-term F 393 - S15 D 241 C.S15.13
Van-der-waals C-term F 393 - S15 D 241 C.S15.13
Hydrophobic TM3 R 163 3x50 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 R 163 3x50 s5s6 L 74 N.s5s6.10
Van-der-waals C-term V 415 - S15 R 237 C.S15.09
Polar TM2 S 98 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 98 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 98 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic C-term S 375 - S6 K 78 N.S6.03
Polar ICL2 K 174 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 K 174 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 K 174 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 R 95 12x49 s20c Q 407 C.s20c.17
Van-der-waals ICL1 R 95 12x49 s20c Q 407 C.s20c.17
Polar C-term N 356 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term N 356 - s9s10 K 161 N.s9s10.12
Polar C-term A 357 - s20c Q 407 C.s20c.17
Hydrophobic C-term A 357 - s20c Q 407 C.s20c.17
Van-der-waals C-term A 357 - s20c Q 407 C.s20c.17
Hydrophobic TM3 T 166 3x53 s8s9 K 139 N.s8s9.09
Polar C-term S 375 - S6 L 80 N.S6.05
Van-der-waals C-term S 375 - S6 L 80 N.S6.05
Ionic C-term K 386 - s17s18 E 309 C.s17s18.34
Polar C-term K 386 - s17s18 E 309 C.s17s18.34
Hydrophobic C-term K 386 - s17s18 E 309 C.s17s18.34
Van-der-waals C-term K 386 - s17s18 E 309 C.s17s18.34
Hydrophobic C-term S 364 - s9s10 K 158 N.s9s10.09
Van-der-waals C-term S 364 - s9s10 K 158 N.s9s10.09
Hydrophobic TM6 I 275 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 N 265 6x24 S6 F 76 N.S6.01
Van-der-waals TM6 N 265 6x24 S6 F 76 N.S6.01
Hydrophobic TM3 T 166 3x53 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 T 166 3x53 s5s6 L 74 N.s5s6.10
Polar C-term P 378 - s7s8 N 123 N.s7s8.05
Hydrophobic TM6 P 268 6x27 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 P 268 6x27 s5s6 S 75 N.s5s6.11
Hydrophobic C-term Y 371 - S6 I 82 N.S6.07
Van-der-waals C-term Y 371 - S6 I 82 N.S6.07
Hydrophobic TM6 M 264 6x23 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 P 268 6x27 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 P 268 6x27 s5s6 G 73 N.s5s6.09
Ionic C-term D 394 - S18 R 323 C.S18.06
Polar C-term D 394 - S18 R 323 C.S18.06
Van-der-waals C-term D 394 - S18 R 323 C.S18.06
Polar ICL1 Q 97 12x51 s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 Q 97 12x51 s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 Q 97 12x51 s5s6 D 68 N.s5s6.04
Hydrophobic C-term M 380 - s17s18 G 310 C.s17s18.35
Van-der-waals C-term M 380 - s17s18 G 310 C.s17s18.35
Hydrophobic TM6 K 271 6x30 s5s6 S 75 N.s5s6.11
Hydrophobic C-term Y 390 - s17s18 I 306 C.s17s18.31
Van-der-waals C-term Y 390 - s17s18 I 306 C.s17s18.31
Polar TM6 K 271 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 K 271 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 K 271 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic C-term Y 358 - s20c C 409 C.s20c.19
Van-der-waals C-term Y 358 - s20c C 409 C.s20c.19
Hydrophobic C-term I 360 - S10 R 166 N.S10.03
Van-der-waals C-term I 360 - S10 R 166 N.S10.03
Polar ICL2 K 174 - s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 K 174 - s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 K 174 - s8s9 G 138 N.s8s9.08
Hydrophobic C-term F 393 - S18 L 319 C.S18.02
Van-der-waals C-term F 393 - S18 L 319 C.S18.02
Polar ICL1 Q 97 12x51 s20c Y 404 C.s20c.14
Hydrophobic C-term Y 390 - s3s4 L 32 N.s3s4.02
Van-der-waals C-term Y 390 - s3s4 L 32 N.s3s4.02
Hydrophobic C-term T 362 - s9s10 K 161 N.s9s10.12
Polar ICL1 R 94 12x48 s20c Y 404 C.s20c.14
Hydrophobic ICL1 R 94 12x48 s20c Y 404 C.s20c.14
Hydrophobic C-term I 377 - s7s8 L 124 N.s7s8.06
Van-der-waals C-term I 377 - s7s8 L 124 N.s7s8.06
Polar C-term Y 390 - s10s11 P 176 C.s10s11.02
Polar C-term K 368 - s9s10 E 156 N.s9s10.07
Hydrophobic C-term K 368 - s9s10 E 156 N.s9s10.07
Van-der-waals C-term K 368 - s9s10 E 156 N.s9s10.07
Ionic ICL1 R 95 12x49 s20c D 403 C.s20c.13
Polar ICL1 R 95 12x49 s20c D 403 C.s20c.13
Hydrophobic ICL1 R 95 12x49 s20c D 403 C.s20c.13
Van-der-waals ICL1 R 95 12x49 s20c D 403 C.s20c.13
Hydrophobic TM2 T 100 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic C-term Y 390 - S19 V 343 C.S19.10
Polar TM6 T 263 6x22 s17s18 E 314 C.s17s18.39
Hydrophobic TM6 T 263 6x22 s17s18 E 314 C.s17s18.39
Van-der-waals TM6 T 263 6x22 s17s18 E 314 C.s17s18.39
Polar ICL1 R 95 12x49 s20c Y 404 C.s20c.14
Aromatic ICL1 R 95 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 R 95 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 R 95 12x49 s20c Y 404 C.s20c.14
Polar ICL3 R 261 - S6 K 78 N.S6.03
Hydrophobic ICL3 R 261 - S6 K 78 N.S6.03
Van-der-waals ICL3 R 261 - S6 K 78 N.S6.03
Polar C-term K 368 - s9s10 E 157 N.s9s10.08
Hydrophobic C-term K 368 - s9s10 E 157 N.s9s10.08
Van-der-waals C-term K 368 - s9s10 E 157 N.s9s10.08
Hydrophobic C-term K 368 - s9s10 K 158 N.s9s10.09
Hydrophobic C-term I 406 - S16 A 248 C.S16.01
Hydrophobic C-term Y 390 - s10s11 A 175 C.s10s11.01
Hydrophobic TM6 T 274 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 274 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic C-term F 393 - s17s18 K 313 C.s17s18.38
Van-der-waals C-term F 393 - s17s18 K 313 C.s17s18.38
Hydrophobic C-term Y 358 - s20c Q 407 C.s20c.17
Van-der-waals C-term Y 358 - s20c Q 407 C.s20c.17
Ionic C-term E 396 - S18 R 323 C.S18.06
Polar C-term E 396 - S18 R 323 C.S18.06
Hydrophobic C-term E 396 - S18 R 323 C.S18.06
Van-der-waals C-term E 396 - S18 R 323 C.S18.06
Polar TM6 K 271 6x30 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 K 271 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 271 6x30 s5s6 G 73 N.s5s6.09
Polar C-term Y 390 - s10s11 K 178 C.s10s11.04
Hydrophobic C-term Y 390 - s10s11 K 178 C.s10s11.04
Van-der-waals C-term Y 390 - s10s11 K 178 C.s10s11.04
Polar TM6 T 274 6x33 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 T 274 6x33 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 274 6x33 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 I 167 3x54 s5s6 L 74 N.s5s6.10
Polar C-term W 404 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term W 404 - s15s16 T 247 C.s15s16.05
Van-der-waals C-term W 404 - s15s16 T 247 C.s15s16.05
Hydrophobic TM3 R 163 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 163 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 171 34x51 S5 Y 64 N.S5.12
Hydrophobic C-term I 360 - s9s10 K 161 N.s9s10.12
Hydrophobic TM6 F 278 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 F 278 6x37 s5s6 L 72 N.s5s6.08
Polar C-term T 359 - s20c Q 407 C.s20c.17
Van-der-waals C-term T 359 - s20c Q 407 C.s20c.17
Van-der-waals TM6 N 265 6x24 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 T 263 6x22 s15s16 L 244 C.s15s16.02
Van-der-waals TM6 T 263 6x22 s15s16 L 244 C.s15s16.02
Hydrophobic C-term I 377 - s7s8 N 123 N.s7s8.05
Van-der-waals C-term I 377 - s7s8 N 123 N.s7s8.05
Polar C-term K 368 - s9s10 L 155 N.s9s10.03
Van-der-waals C-term K 368 - s9s10 L 155 N.s9s10.03
Hydrophobic C-term R 395 - S16 Q 249 C.S16.02
Hydrophobic ICL2 K 174 - s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 K 174 - s8s9 K 139 N.s8s9.09