Arrestin-C - GPR19 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR19 62.8
Arrestin-C 78.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 N 334 8x47 s5s6 I 67 N.s5s6.08
Van-der-waals H8 N 334 8x47 s5s6 I 67 N.s5s6.08
Hydrophobic C-term I 360 - S9 E 142 N.S9.06
Van-der-waals C-term I 360 - S9 E 142 N.S9.06
Hydrophobic C-term I 374 - s7s8 L 120 N.s7s8.06
Hydrophobic TM2 T 100 2x39 s5s6 L 69 N.s5s6.10
Van-der-waals TM2 T 100 2x39 s5s6 L 69 N.s5s6.10
Hydrophobic C-term Y 358 - s5s6 E 65 N.s5s6.06
Hydrophobic TM6 N 265 6x24 s15s16 L 240 C.s15s16.02
Van-der-waals TM6 N 265 6x24 s15s16 L 240 C.s15s16.02
Hydrophobic C-term I 374 - s17s18 L 311 C.s17s18.40
Polar C-term N 356 - s9s10 K 157 N.s9s10.12
Hydrophobic C-term N 356 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term N 356 - s9s10 K 157 N.s9s10.12
Polar ICL2 L 171 34x51 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 L 171 34x51 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 L 171 34x51 s8s9 K 135 N.s8s9.09
Polar C-term M 350 - s9s10 R 158 N.s9s10.13
Van-der-waals C-term M 350 - s9s10 R 158 N.s9s10.13
Polar C-term Y 371 - S6 V 77 N.S6.07
Hydrophobic C-term Y 371 - S6 V 77 N.S6.07
Van-der-waals C-term Y 371 - S6 V 77 N.S6.07
Polar ICL1 R 95 12x49 s5s6 D 62 N.s5s6.03
Van-der-waals ICL1 R 95 12x49 s5s6 D 62 N.s5s6.03
Polar ICL1 R 95 12x49 s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 R 95 12x49 s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 R 95 12x49 s5s6 D 63 N.s5s6.04
Hydrophobic ICL3 V 260 - s17s18 D 308 C.s17s18.37
Hydrophobic ICL2 L 171 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 171 34x51 S16 Y 246 C.S16.03
Hydrophobic TM3 T 166 3x53 s5s6 L 69 N.s5s6.10
Polar TM6 T 263 6x22 s17s18 L 311 C.s17s18.40
Hydrophobic TM6 T 263 6x22 s17s18 L 311 C.s17s18.40
Van-der-waals TM6 T 263 6x22 s17s18 L 311 C.s17s18.40
Hydrophobic C-term I 374 - s7s8 N 119 N.s7s8.05
Hydrophobic ICL1 Q 97 12x51 s5s6 L 64 N.s5s6.05
Van-der-waals ICL1 Q 97 12x51 s5s6 L 64 N.s5s6.05
Polar ICL1 Q 97 12x51 s5s6 R 61 N.s5s6.02
Hydrophobic ICL1 Q 97 12x51 s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 Q 97 12x51 s5s6 R 61 N.s5s6.02
Polar ICL1 Q 97 12x51 s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 Q 97 12x51 s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 Q 97 12x51 s5s6 D 63 N.s5s6.04
Hydrophobic TM4 R 177 4x39 s5s6 R 61 N.s5s6.02
Van-der-waals TM4 R 177 4x39 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 K 271 6x30 S6 F 71 N.S6.01
Van-der-waals TM6 K 271 6x30 S6 F 71 N.S6.01
Hydrophobic TM3 R 163 3x50 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 R 163 3x50 s5s6 L 69 N.s5s6.10
Polar TM6 T 274 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic C-term I 374 - s7s8 V 117 N.s7s8.03
Hydrophobic C-term I 360 - S6 R 72 N.S6.02
Hydrophobic ICL2 L 171 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 171 34x51 S15 V 238 C.S15.14
Hydrophobic TM6 P 268 6x27 S6 F 71 N.S6.01
Van-der-waals TM6 P 268 6x27 S6 F 71 N.S6.01
Polar ICL2 P 170 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 P 170 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 170 34x50 s15s16 S 242 C.s15s16.04
Polar ICL2 S 172 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 S 172 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 S 172 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 L 171 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 171 34x51 S16 D 244 C.S16.01
Polar ICL3 R 262 - S6 K 73 N.S6.03
Van-der-waals ICL3 R 262 - S6 K 73 N.S6.03
Polar TM6 T 263 6x22 S6 K 73 N.S6.03
Hydrophobic TM6 T 263 6x22 S6 K 73 N.S6.03
Van-der-waals TM6 T 263 6x22 S6 K 73 N.S6.03
Hydrophobic C-term A 357 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term A 357 - s9s10 K 157 N.s9s10.12
Hydrophobic ICL2 P 170 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 170 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL1 R 95 12x49 s5s6 V 66 N.s5s6.07
Van-der-waals ICL1 R 95 12x49 s5s6 V 66 N.s5s6.07
Polar ICL2 L 171 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 171 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 171 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic TM2 T 100 2x39 s5s6 I 67 N.s5s6.08
Polar TM6 K 271 6x30 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 K 271 6x30 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 K 271 6x30 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 171 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic TM6 M 264 6x23 s15s16 L 240 C.s15s16.02
Polar C-term T 359 - s5s6 E 65 N.s5s6.06
Hydrophobic C-term T 359 - s5s6 E 65 N.s5s6.06
Van-der-waals C-term T 359 - s5s6 E 65 N.s5s6.06
Ionic C-term K 368 - s9s10 E 152 N.s9s10.07
Polar C-term K 368 - s9s10 E 152 N.s9s10.07
Hydrophobic C-term K 368 - s9s10 E 152 N.s9s10.07
Van-der-waals C-term K 368 - s9s10 E 152 N.s9s10.07
Polar ICL2 K 174 - S5 Y 59 N.S5.12
Hydrophobic ICL2 K 174 - S5 Y 59 N.S5.12
Van-der-waals ICL2 K 174 - S5 Y 59 N.S5.12
Polar H8 N 336 8x49 s5s6 V 66 N.s5s6.07
Hydrophobic H8 N 336 8x49 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 336 8x49 s5s6 V 66 N.s5s6.07
Ionic C-term R 365 - s9s10 E 152 N.s9s10.07
Polar TM3 T 166 3x53 s15s16 Y 241 C.s15s16.03
Van-der-waals TM3 T 166 3x53 s15s16 Y 241 C.s15s16.03
Polar TM6 T 274 6x33 s5s6 I 67 N.s5s6.08
Ionic ICL3 R 261 - s17s18 D 308 C.s17s18.37
Polar ICL3 R 261 - s17s18 D 308 C.s17s18.37
Hydrophobic ICL3 R 261 - s17s18 D 308 C.s17s18.37
Van-der-waals ICL3 R 261 - s17s18 D 308 C.s17s18.37
Van-der-waals H8 N 334 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 N 101 2x40 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 N 101 2x40 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 K 174 - s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 K 174 - s8s9 K 135 N.s8s9.09
Hydrophobic C-term R 354 - s9s10 R 158 N.s9s10.13
Hydrophobic C-term T 362 - s9s10 T 154 N.s9s10.09
Hydrophobic TM2 S 98 2x37 s5s6 L 64 N.s5s6.05
Van-der-waals TM2 S 98 2x37 s5s6 L 64 N.s5s6.05
Polar TM6 N 265 6x24 S6 R 72 N.S6.02
Hydrophobic C-term I 360 - S10 Y 160 N.S10.01
Van-der-waals C-term I 360 - S10 Y 160 N.S10.01
Polar ICL2 P 170 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 170 34x50 S5 Y 59 N.S5.12
Polar TM6 K 271 6x30 s5s6 G 68 N.s5s6.09
Polar TM6 T 263 6x22 s17s18 D 308 C.s17s18.37
Van-der-waals TM6 T 263 6x22 s17s18 D 308 C.s17s18.37
Polar TM6 M 264 6x23 S6 K 73 N.S6.03
Hydrophobic TM6 M 264 6x23 S6 K 73 N.S6.03
Van-der-waals TM6 M 264 6x23 S6 K 73 N.S6.03
Hydrophobic C-term Y 371 - S6 Y 76 N.S6.06
Van-der-waals C-term Y 371 - S6 Y 76 N.S6.06
Hydrophobic TM6 M 264 6x23 s15s16 V 239 C.s15s16.01
Van-der-waals TM6 M 264 6x23 s15s16 V 239 C.s15s16.01
Polar C-term I 360 - s5s6 E 65 N.s5s6.06
Polar ICL2 K 174 - s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 K 174 - s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 K 174 - s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 L 171 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 171 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL1 R 95 12x49 s5s6 L 64 N.s5s6.05
Van-der-waals ICL1 R 95 12x49 s5s6 L 64 N.s5s6.05
Ionic ICL3 R 261 - s17s18 E 310 C.s17s18.39
Polar ICL3 R 261 - s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 R 261 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 R 261 - s17s18 E 310 C.s17s18.39
Polar H8 N 336 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 336 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 336 8x49 s5s6 E 65 N.s5s6.06
Ionic ICL1 R 95 12x49 s5s6 E 65 N.s5s6.06
Polar ICL1 R 95 12x49 s5s6 E 65 N.s5s6.06
Hydrophobic ICL1 R 95 12x49 s5s6 E 65 N.s5s6.06
Van-der-waals ICL1 R 95 12x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 M 264 6x23 s17s18 E 310 C.s17s18.39
Van-der-waals TM6 M 264 6x23 s17s18 E 310 C.s17s18.39
Polar TM6 N 265 6x24 S6 K 73 N.S6.03
Hydrophobic TM6 N 265 6x24 S6 K 73 N.S6.03
Van-der-waals TM6 N 265 6x24 S6 K 73 N.S6.03
Polar TM6 T 270 6x29 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 T 270 6x29 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 T 270 6x29 s5s6 G 68 N.s5s6.09
Van-der-waals TM2 S 98 2x37 s5s6 L 69 N.s5s6.10