S-arrestin - GPR19 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR19 64.8
S-arrestin 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 T 274 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 T 274 6x33 s5s6 L 81 N.s5s6.10
Polar ICL2 P 170 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 170 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 170 34x50 S5 Y 71 N.S5.12
Hydrophobic TM2 T 100 2x39 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 T 100 2x39 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 171 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 L 171 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 L 171 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 171 34x51 S15 V 251 C.S15.14
Polar ICL2 S 172 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 S 172 34x52 s15s16 S 255 C.s15s16.04
Ionic C-term R 354 - s20c D 402 C.s20c.21
Polar C-term R 354 - s20c D 402 C.s20c.21
Van-der-waals C-term R 354 - s20c D 402 C.s20c.21
Polar TM2 N 101 2x40 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 N 101 2x40 s5s6 I 76 N.s5s6.05
Polar TM4 R 177 4x39 s8s9 S 143 N.s8s9.07
Van-der-waals TM4 R 177 4x39 s8s9 S 143 N.s8s9.07
Polar ICL2 K 174 - S5 Y 71 N.S5.12
Hydrophobic ICL2 K 174 - S5 Y 71 N.S5.12
Van-der-waals ICL2 K 174 - S5 Y 71 N.S5.12
Polar C-term V 415 - s11s12 F 201 C.s11s12.02
Hydrophobic C-term V 415 - s11s12 F 201 C.s11s12.02
Van-der-waals C-term V 415 - s11s12 F 201 C.s11s12.02
Polar TM6 K 271 6x30 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 K 271 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 K 271 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 K 271 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 R 163 3x50 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 R 163 3x50 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 M 107 2x46 s5s6 I 79 N.s5s6.08
Polar C-term Y 353 - s20c R 398 C.s20c.17
Hydrophobic C-term Y 353 - s20c R 398 C.s20c.17
Van-der-waals C-term Y 353 - s20c R 398 C.s20c.17
Hydrophobic ICL3 V 260 - s17s18 V 324 C.s17s18.40
Hydrophobic TM6 P 268 6x27 S6 F 83 N.S6.01
Polar C-term A 357 - s1s2 R 22 N.s1s2.02
Hydrophobic C-term A 357 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term A 357 - s1s2 R 22 N.s1s2.02
Hydrophobic TM3 T 166 3x53 s5s6 L 81 N.s5s6.10
Polar TM4 R 177 4x39 s8s9 Q 141 N.s8s9.05
Hydrophobic TM4 R 177 4x39 s8s9 Q 141 N.s8s9.05
Van-der-waals TM4 R 177 4x39 s8s9 Q 141 N.s8s9.05
Polar ICL2 S 172 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 S 172 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 S 172 34x52 S16 D 257 C.S16.01
Polar TM2 S 98 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 S 98 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 S 98 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM6 I 275 6x34 s5s6 L 81 N.s5s6.10
Hydrophobic TM1 I 90 1x57 s5s6 V 78 N.s5s6.07
Polar ICL1 Q 97 12x51 s8s9 S 143 N.s8s9.07
Polar H8 N 334 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 334 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 L 171 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 L 171 34x51 S9 C 147 N.S9.01
Polar TM6 M 264 6x23 S6 D 86 N.S6.04
Hydrophobic TM6 M 264 6x23 S6 D 86 N.S6.04
Van-der-waals TM6 M 264 6x23 S6 D 86 N.S6.04
Polar TM6 N 265 6x24 S6 R 85 N.S6.03
Hydrophobic TM6 N 265 6x24 S6 R 85 N.S6.03
Van-der-waals TM6 N 265 6x24 S6 R 85 N.S6.03
Van-der-waals TM6 T 263 6x22 S6 D 86 N.S6.04
Hydrophobic H8 N 336 8x49 s5s6 I 76 N.s5s6.05
Ionic TM6 R 269 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 R 269 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 269 6x28 s9s10 D 166 N.s9s10.08
Polar H8 N 334 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 N 334 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 N 334 8x47 s5s6 V 78 N.s5s6.07
Polar TM6 T 270 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 T 270 6x29 s5s6 T 82 N.s5s6.11
Ionic ICL1 R 95 12x49 s20c E 395 C.s20c.14
Polar ICL1 R 95 12x49 s20c E 395 C.s20c.14
Polar H8 N 336 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 N 336 8x49 s5s6 D 75 N.s5s6.04
Polar TM2 N 101 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 101 2x40 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 F 278 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 F 278 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 N 101 2x40 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 I 159 3x46 s5s6 I 79 N.s5s6.08
Ionic ICL1 R 94 12x48 s20c E 394 C.s20c.13
Polar ICL1 R 94 12x48 s20c E 394 C.s20c.13
Hydrophobic ICL1 R 94 12x48 s20c E 394 C.s20c.13
Van-der-waals ICL1 R 94 12x48 s20c E 394 C.s20c.13
Hydrophobic TM6 P 268 6x27 S6 R 84 N.S6.02
Van-der-waals TM6 P 268 6x27 S6 R 84 N.S6.02
Hydrophobic C-term F 414 - s11s12 F 201 C.s11s12.02
Hydrophobic C-term V 415 - s11s12 F 200 C.s11s12.01
Van-der-waals C-term V 415 - s11s12 F 200 C.s11s12.01
Polar TM4 R 177 4x39 s8s9 P 140 N.s8s9.04
Polar C-term S 363 - s9s10 D 166 N.s9s10.08
Hydrophobic C-term S 363 - s9s10 D 166 N.s9s10.08
Van-der-waals C-term S 363 - s9s10 D 166 N.s9s10.08
Polar C-term S 349 - s20c R 398 C.s20c.17
Hydrophobic H8 F 337 8x50 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 P 170 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 170 34x50 s15s16 Y 254 C.s15s16.03
Polar C-term I 360 - s9s10 K 170 N.s9s10.12
Hydrophobic C-term I 360 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term I 360 - s9s10 K 170 N.s9s10.12
Polar TM3 I 167 3x54 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 I 167 3x54 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 I 167 3x54 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 K 174 - s5s6 G 72 N.s5s6.01
Polar ICL2 L 171 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 L 171 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 L 171 34x51 s15s16 S 255 C.s15s16.04
Ionic TM3 R 163 3x50 s5s6 D 77 N.s5s6.06
Ionic ICL1 R 95 12x49 s5s6 E 74 N.s5s6.03
Polar ICL1 R 95 12x49 s5s6 E 74 N.s5s6.03
Hydrophobic TM6 M 277 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 M 264 6x23 S6 F 89 N.S6.07
Van-der-waals TM6 M 264 6x23 S6 F 89 N.S6.07
Polar TM3 T 166 3x53 s15s16 Y 254 C.s15s16.03
Polar ICL2 L 171 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 171 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 171 34x51 S16 D 257 C.S16.01
Polar TM6 T 274 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 T 274 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 T 274 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 T 263 6x22 S6 L 87 N.S6.05
Van-der-waals TM6 T 263 6x22 S6 L 87 N.S6.05
Polar C-term T 362 - s9s10 K 170 N.s9s10.12
Hydrophobic C-term T 362 - s9s10 K 170 N.s9s10.12
Hydrophobic TM1 S 93 1x60 s5s6 I 76 N.s5s6.05
Van-der-waals TM1 S 93 1x60 s5s6 I 76 N.s5s6.05
Polar TM3 R 163 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 163 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM4 S 176 4x38 s8s9 D 142 N.s8s9.06
Van-der-waals TM4 S 176 4x38 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 T 274 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 274 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic H8 G 340 8x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM7 Y 330 7x53 s5s6 I 79 N.s5s6.08
Ionic ICL1 R 95 12x49 s5s6 D 75 N.s5s6.04
Polar ICL1 R 95 12x49 s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 R 95 12x49 s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 R 95 12x49 s5s6 D 75 N.s5s6.04
Hydrophobic TM6 K 271 6x30 S6 F 83 N.S6.01
Van-der-waals TM6 K 271 6x30 S6 F 83 N.S6.01
Polar TM2 S 98 2x37 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 S 98 2x37 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 S 98 2x37 s5s6 D 77 N.s5s6.06
Polar ICL2 L 171 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 171 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 171 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL3 V 260 - s17s18 D 321 C.s17s18.37
Hydrophobic ICL2 L 171 34x51 S5 F 69 N.S5.10
Polar ICL1 Q 97 12x51 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL1 Q 97 12x51 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 Q 97 12x51 s5s6 Q 73 N.s5s6.02
Van-der-waals C-term V 415 - S11 Q 199 C.S11.06
Hydrophobic TM7 Y 330 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 330 7x53 s5s6 V 78 N.s5s6.07
Ionic TM6 R 269 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 269 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 269 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 269 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic C-term I 360 - S10 R 175 N.S10.03
Van-der-waals C-term I 360 - S10 R 175 N.S10.03
Hydrophobic ICL2 P 170 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 K 174 - s8s9 K 145 N.s8s9.09
Polar ICL2 K 174 - s8s9 G 144 N.s8s9.08
Hydrophobic ICL2 K 174 - s8s9 G 144 N.s8s9.08
Van-der-waals ICL2 K 174 - s8s9 G 144 N.s8s9.08
Hydrophobic TM3 I 167 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 167 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 V 104 2x43 s5s6 V 78 N.s5s6.07
Polar TM2 T 100 2x39 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 T 100 2x39 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 T 100 2x39 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 M 277 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 M 277 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 V 104 2x43 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 V 104 2x43 s5s6 I 79 N.s5s6.08