Beta-arrestin-2 - GPR20 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR20 74.6
Beta-arrestin-2 82.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM7 C 298 7x54 s5s6 L 69 N.s5s6.05
Polar TM6 Q 231 6x25 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 Q 231 6x25 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 Q 231 6x25 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 Q 231 6x25 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 148 3x50 s5s6 D 70 N.s5s6.06
Polar C-term V 326 - S16 Q 249 C.S16.02
Hydrophobic C-term V 326 - S16 Q 249 C.S16.02
Van-der-waals C-term V 326 - S16 Q 249 C.S16.02
Hydrophobic H8 T 301 8x47 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 V 89 2x40 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 I 152 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 155 34x50 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 P 155 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 I 152 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 R 235 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 V 89 2x40 s5s6 L 69 N.s5s6.05
Hydrophobic C-term S 321 - s17s18 K 285 C.s17s18.10
Van-der-waals C-term S 321 - s17s18 K 285 C.s17s18.10
Hydrophobic TM3 I 152 3x54 s5s6 V 71 N.s5s6.07
Polar ICL1 T 82 12x48 s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 T 82 12x48 s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 T 82 12x48 s8s9 E 135 N.s8s9.05
Hydrophobic C-term V 325 - S16 Y 250 C.S16.03
Van-der-waals C-term V 325 - S16 Y 250 C.S16.03
Ionic ICL2 E 156 34x51 S6 K 78 N.S6.03
Polar ICL2 E 156 34x51 S6 K 78 N.S6.03
Van-der-waals ICL2 E 156 34x51 S6 K 78 N.S6.03
Polar TM6 R 235 6x29 s20c Q 407 C.s20c.17
Hydrophobic TM6 R 235 6x29 s5s6 R 66 N.s5s6.02
Van-der-waals TM6 R 235 6x29 s5s6 R 66 N.s5s6.02
Hydrophobic H8 T 301 8x47 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 A 239 6x33 s5s6 L 72 N.s5s6.08
Polar TM2 S 88 2x39 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 S 88 2x39 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 S 88 2x39 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 A 151 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 A 239 6x33 s5s6 L 74 N.s5s6.10
Polar ICL2 R 159 34x54 s15s16 C 243 C.s15s16.01
Hydrophobic ICL2 R 159 34x54 s15s16 C 243 C.s15s16.01
Van-der-waals ICL2 R 159 34x54 s15s16 C 243 C.s15s16.01
Hydrophobic TM3 R 148 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 148 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 R 159 34x54 s15s16 L 244 C.s15s16.02
Van-der-waals ICL2 R 159 34x54 s15s16 L 244 C.s15s16.02
Polar TM2 T 86 2x37 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 T 86 2x37 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 T 86 2x37 s5s6 D 70 N.s5s6.06
Polar H8 G 303 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 G 303 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 G 303 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM6 R 236 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 S 88 2x39 s5s6 L 69 N.s5s6.05
Polar C-term S 321 - s17s18 R 286 C.s17s18.11
Hydrophobic TM6 L 243 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 243 6x37 s5s6 L 72 N.s5s6.08
Aromatic ICL2 R 159 34x54 s15s16 F 245 C.s15s16.03
Polar TM6 R 235 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 235 6x29 s5s6 G 73 N.s5s6.09
Polar H8 T 307 8x53 s8s9 P 134 N.s8s9.04
Hydrophobic ICL1 T 82 12x48 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 T 82 12x48 s8s9 T 137 N.s8s9.07
Hydrophobic C-term G 323 - S16 K 251 C.S16.04
Van-der-waals C-term G 323 - S16 K 251 C.S16.04
Hydrophobic C-term V 326 - S16 K 251 C.S16.04
Ionic ICL2 R 162 34x57 s5s6 D 70 N.s5s6.06
Polar ICL2 R 162 34x57 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 R 162 34x57 s5s6 D 70 N.s5s6.06
Van-der-waals ICL2 R 162 34x57 s5s6 D 70 N.s5s6.06
Ionic ICL1 R 83 12x49 s8s9 D 136 N.s8s9.06
Van-der-waals ICL1 R 83 12x49 s8s9 D 136 N.s8s9.06
Hydrophobic TM1 F 78 1x57 s5s6 L 69 N.s5s6.05
Van-der-waals TM1 F 78 1x57 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 A 151 3x53 s5s6 D 70 N.s5s6.06
Polar TM6 R 235 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 235 6x29 s5s6 S 75 N.s5s6.11
Polar H8 S 302 8x48 s5s6 E 67 N.s5s6.03
Hydrophobic H8 S 302 8x48 s5s6 E 67 N.s5s6.03
Van-der-waals H8 S 302 8x48 s5s6 E 67 N.s5s6.03
Ionic TM6 H 230 6x24 S6 D 79 N.S6.04
Polar TM6 H 230 6x24 S6 D 79 N.S6.04
Ionic TM1 R 81 1x60 s8s9 E 135 N.s8s9.05
Polar TM1 R 81 1x60 s8s9 E 135 N.s8s9.05
Hydrophobic TM1 R 81 1x60 s8s9 E 135 N.s8s9.05
Van-der-waals TM1 R 81 1x60 s8s9 E 135 N.s8s9.05
Hydrophobic C-term L 341 - s12s13 E 207 C.s12s13.03
Van-der-waals C-term L 341 - s12s13 E 207 C.s12s13.03
Hydrophobic C-term V 325 - s8s9 D 136 N.s8s9.06
Van-der-waals C-term V 325 - s8s9 D 136 N.s8s9.06
Ionic ICL2 R 159 34x54 s17s18 E 314 C.s17s18.39
Polar ICL2 R 159 34x54 s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 R 159 34x54 s17s18 E 314 C.s17s18.39
Van-der-waals ICL2 R 159 34x54 s17s18 E 314 C.s17s18.39
Aromatic TM6 H 230 6x24 S6 R 77 N.S6.02
Hydrophobic TM6 H 230 6x24 S6 R 77 N.S6.02
Polar C-term S 342 - s17s18 E 309 C.s17s18.34
Hydrophobic C-term S 342 - s17s18 E 309 C.s17s18.34
Van-der-waals C-term S 342 - s17s18 E 309 C.s17s18.34
Hydrophobic C-term G 323 - S16 C 252 C.S16.05
Hydrophobic TM3 A 151 3x53 S6 F 76 N.S6.01
Hydrophobic TM5 L 223 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 223 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic C-term V 325 - S16 Q 249 C.S16.02
Van-der-waals C-term V 325 - S16 Q 249 C.S16.02
Polar C-term D 324 - S16 K 251 C.S16.04
Hydrophobic C-term D 324 - S16 K 251 C.S16.04
Van-der-waals C-term D 324 - S16 K 251 C.S16.04
Hydrophobic TM6 L 229 6x23 S6 F 76 N.S6.01
Polar TM3 R 148 3x50 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 R 148 3x50 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 I 152 3x54 S6 F 76 N.S6.01
Hydrophobic TM7 Y 297 7x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM7 Y 297 7x53 s5s6 L 69 N.s5s6.05
Polar ICL1 A 84 12x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 A 84 12x50 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 L 242 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 242 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic C-term M 328 - S15 D 241 C.S15.13
Van-der-waals C-term M 328 - S15 D 241 C.S15.13
Ionic ICL1 R 83 12x49 s8s9 E 135 N.s8s9.05
Polar ICL1 R 83 12x49 s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 R 83 12x49 s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 R 83 12x49 s8s9 E 135 N.s8s9.05
Hydrophobic C-term M 328 - S16 Q 249 C.S16.02
Van-der-waals C-term M 328 - S16 Q 249 C.S16.02