S-arrestin - GPR20 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR20 71.2
S-arrestin 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 E 156 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 E 156 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 L 243 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 152 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 I 152 3x54 s5s6 I 79 N.s5s6.08
Polar ICL3 L 228 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 L 228 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL1 A 84 12x50 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 A 84 12x50 s5s6 Q 73 N.s5s6.02
Polar ICL2 R 159 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 R 159 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 R 159 34x54 S5 Y 71 N.S5.12
Hydrophobic TM5 L 223 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 223 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 I 152 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 152 3x54 S6 F 83 N.S6.01
Hydrophobic TM7 Y 297 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 297 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 L 242 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 148 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 148 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL1 A 84 12x50 s8s9 S 143 N.s8s9.07
Van-der-waals ICL1 A 84 12x50 s8s9 S 143 N.s8s9.07
Hydrophobic H8 A 306 8x52 s20c R 398 C.s20c.17
Hydrophobic TM2 S 88 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 S 88 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 A 239 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 239 6x33 s5s6 L 81 N.s5s6.10
Ionic TM6 R 233 6x27 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 233 6x27 s9s10 E 164 N.s9s10.06
Polar ICL2 E 156 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 E 156 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 E 156 34x51 s15s16 Y 254 C.s15s16.03
Polar H8 G 303 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 G 303 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 G 303 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 T 86 2x37 s8s9 G 144 N.s8s9.08
Polar H8 G 303 8x49 s20c R 398 C.s20c.17
Hydrophobic TM6 H 230 6x24 S6 R 85 N.S6.03
Hydrophobic TM6 A 239 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 239 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 L 242 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 242 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 155 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 155 34x50 s15s16 Y 254 C.s15s16.03
Polar TM6 Q 231 6x25 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 Q 231 6x25 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 Q 231 6x25 s5s6 T 82 N.s5s6.11
Polar H8 Q 314 8x60 s20c E 394 C.s20c.13
Ionic TM1 R 81 1x60 s20c E 394 C.s20c.13
Polar TM3 R 148 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 148 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 148 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 R 235 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic H8 T 301 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 T 301 8x47 s5s6 V 78 N.s5s6.07
Ionic H8 R 309 8x55 s20c E 405 C.s20c.24
Hydrophobic TM6 L 229 6x23 S6 F 83 N.S6.01
Ionic TM6 R 235 6x29 s9s10 D 166 N.s9s10.08
Polar TM6 R 235 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 R 235 6x29 s9s10 D 166 N.s9s10.08
Polar ICL2 R 159 34x54 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 R 159 34x54 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 R 159 34x54 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 I 152 3x54 s5s6 L 81 N.s5s6.10
Polar TM6 H 230 6x24 S6 R 84 N.S6.02
Polar ICL2 R 159 34x54 S16 Y 259 C.S16.03
Hydrophobic TM6 Q 234 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 Q 234 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic H8 T 301 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 T 301 8x47 s5s6 D 77 N.s5s6.06
Ionic ICL2 R 159 34x54 S16 D 257 C.S16.01
Polar ICL2 R 159 34x54 S16 D 257 C.S16.01
Hydrophobic ICL2 R 159 34x54 S16 D 257 C.S16.01
Van-der-waals ICL2 R 159 34x54 S16 D 257 C.S16.01
Hydrophobic TM3 A 151 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 151 3x53 S6 F 83 N.S6.01
Polar H8 T 307 8x53 s20c R 398 C.s20c.17
Van-der-waals H8 T 307 8x53 s20c R 398 C.s20c.17
Polar TM6 H 230 6x24 S6 D 86 N.S6.04
Hydrophobic TM6 H 230 6x24 S6 D 86 N.S6.04
Van-der-waals TM6 H 230 6x24 S6 D 86 N.S6.04
Polar TM6 R 235 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 R 235 6x29 s5s6 T 82 N.s5s6.11
Polar TM6 Q 231 6x25 S6 R 84 N.S6.02
Hydrophobic TM6 Q 231 6x25 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 Q 231 6x25 s5s6 L 81 N.s5s6.10