Beta-arrestin-1 - GPR21 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR21 76.6
Beta-arrestin-1 78.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM2 T 63 2x38 s5s6 R 65 N.s5s6.02
Polar TM3 I 131 3x54 S5 Y 63 N.S5.12
Hydrophobic TM3 I 131 3x54 S5 Y 63 N.S5.12
Van-der-waals TM3 I 131 3x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 134 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 134 34x50 S5 Y 63 N.S5.12
Hydrophobic TM5 I 225 5x73 S6 K 77 N.S6.03
Van-der-waals TM5 I 225 5x73 S6 K 77 N.S6.03
Hydrophobic TM3 I 131 3x54 s5s6 L 68 N.s5s6.05
Polar TM3 T 132 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 T 132 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 T 132 3x55 s15s16 N 245 C.s15s16.04
Polar H8 N 308 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 308 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 308 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 134 34x50 s5s6 G 64 N.s5s6.01
Ionic TM5 R 228 5x76 s17s18 E 313 C.s17s18.39
Polar TM5 R 228 5x76 s17s18 E 313 C.s17s18.39
Hydrophobic TM5 R 228 5x76 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 R 228 5x76 s17s18 E 313 C.s17s18.39
Hydrophobic TM6 V 253 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 253 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 A 130 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 130 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 R 127 3x50 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 R 127 3x50 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 I 214 5x62 s5s6 L 73 N.s5s6.10
Polar TM5 H 221 5x69 s15s16 F 244 C.s15s16.03
Aromatic TM5 H 221 5x69 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 221 5x69 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 H 221 5x69 s15s16 F 244 C.s15s16.03
Ionic TM2 H 62 2x37 s5s6 D 67 N.s5s6.04
Polar TM2 H 62 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 H 62 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 H 62 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 F 232 5x80 s7s8 L 123 N.s7s8.06
Van-der-waals TM5 F 232 5x80 s7s8 L 123 N.s7s8.06
Hydrophobic TM6 I 257 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 257 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 Y 250 6x33 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 Y 250 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 L 135 34x51 S16 A 247 C.S16.01
Hydrophobic TM5 Y 211 5x59 s5s6 L 71 N.s5s6.08
Polar ICL2 N 138 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 N 138 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 N 138 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 R 127 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 127 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 Y 304 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 304 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic ICL1 H 61 - s8s9 T 136 N.s8s9.07
Ionic TM3 R 127 3x50 s5s6 D 67 N.s5s6.04
Polar TM3 R 127 3x50 s5s6 D 67 N.s5s6.04
Polar TM6 Y 250 6x33 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 Y 250 6x33 s5s6 T 74 N.s5s6.11
Ionic H8 R 317 8x56 s20c E 407 C.s20c.17
Polar H8 R 317 8x56 s20c E 407 C.s20c.17
Hydrophobic H8 R 317 8x56 s20c E 407 C.s20c.17
Van-der-waals H8 R 317 8x56 s20c E 407 C.s20c.17
Polar ICL2 T 136 34x52 S16 Y 249 C.S16.03
Polar H8 S 309 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 309 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 309 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 I 68 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 I 68 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 135 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 L 135 34x51 S9 C 140 N.S9.01
Hydrophobic TM3 I 131 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 131 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 L 135 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 L 135 34x51 S8 L 129 N.S8.03
Hydrophobic TM3 I 131 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 Y 137 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 R 228 5x76 S6 K 77 N.S6.03
Van-der-waals TM5 R 228 5x76 S6 K 77 N.S6.03
Polar ICL1 H 61 - s5s6 R 65 N.s5s6.02
Hydrophobic TM5 F 232 5x80 s17s18 I 314 C.s17s18.40
Van-der-waals TM5 F 232 5x80 s17s18 I 314 C.s17s18.40
Hydrophobic TM6 Y 250 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 Y 250 6x33 s5s6 L 73 N.s5s6.10
Polar H8 V 310 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 V 310 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 V 310 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 L 135 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 135 34x51 S16 Y 249 C.S16.03
Polar TM5 D 224 5x72 S6 K 77 N.S6.03
Hydrophobic TM5 D 224 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 D 224 5x72 S6 K 77 N.S6.03
Hydrophobic TM5 R 228 5x76 s17s18 I 314 C.s17s18.40
Van-der-waals TM5 R 228 5x76 s17s18 I 314 C.s17s18.40
Van-der-waals ICL2 N 138 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 N 138 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 N 138 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM6 L 254 6x37 s5s6 L 73 N.s5s6.10
Ionic H8 R 313 8x52 s5s6 D 69 N.s5s6.06
Polar H8 R 313 8x52 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 R 228 5x76 s15s16 L 243 C.s15s16.02
Van-der-waals TM5 R 228 5x76 s15s16 L 243 C.s15s16.02
Polar TM5 H 221 5x69 S6 K 77 N.S6.03
Hydrophobic H8 N 308 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 N 308 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 C 218 5x66 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 F 232 5x80 S6 L 79 N.S6.05
Hydrophobic ICL2 L 135 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 135 34x51 S15 I 241 C.S15.14
Hydrophobic ICL1 L 58 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 L 58 12x49 s20c E 404 C.s20c.14
Hydrophobic TM5 C 218 5x66 S6 F 75 N.S6.01
Van-der-waals TM5 C 218 5x66 S6 F 75 N.S6.01
Hydrophobic TM2 T 64 2x39 s5s6 V 70 N.s5s6.07