Beta-arrestin-2 - GPR22 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR22 67.7
Beta-arrestin-2 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 T 244 5x71 s17s18 N 312 C.s17s18.37
Hydrophobic TM5 F 246 5x73 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 F 246 5x73 s17s18 V 315 C.s17s18.40
Polar TM6 R 307 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 R 307 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 R 307 6x29 S6 R 77 N.S6.02
Hydrophobic TM5 R 245 5x72 S6 L 80 N.S6.05
Van-der-waals TM5 R 245 5x72 S6 L 80 N.S6.05
Polar TM5 F 246 5x73 S6 L 80 N.S6.05
Hydrophobic TM6 I 318 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 140 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic H8 R 371 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 R 371 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 I 234 5x61 s5s6 L 72 N.s5s6.08
Polar TM2 S 75 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 75 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 75 2x37 s5s6 D 68 N.s5s6.04
Ionic H8 K 373 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 373 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 K 373 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 373 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 376 8x52 s20c C 409 C.s20c.19
Van-der-waals H8 K 376 8x52 s20c C 409 C.s20c.19
Hydrophobic TM5 I 242 5x69 s15s16 L 244 C.s15s16.02
Hydrophobic TM5 I 242 5x69 S6 K 78 N.S6.03
Van-der-waals TM5 I 242 5x69 S6 K 78 N.S6.03
Hydrophobic TM5 R 245 5x72 s17s18 V 315 C.s17s18.40
Hydrophobic ICL2 A 148 34x51 S15 I 242 C.S15.14
Ionic ICL2 R 150 34x53 s8s9 D 136 N.s8s9.06
Hydrophobic TM3 I 143 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 143 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 143 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 G 243 5x70 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 G 243 5x70 s17s18 E 314 C.s17s18.39
Polar TM3 V 145 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 V 145 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM5 R 245 5x72 S6 I 82 N.S6.07
Hydrophobic TM3 S 144 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 S 144 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 A 148 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 A 148 34x51 S8 L 130 N.S8.03
Hydrophobic TM6 V 311 6x33 s5s6 L 72 N.s5s6.08
Polar TM6 R 310 6x32 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 R 310 6x32 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 310 6x32 s5s6 G 73 N.s5s6.09
Polar H8 Q 372 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 Q 372 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 Q 372 8x48 s5s6 D 70 N.s5s6.06
Polar TM2 S 77 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 77 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 77 2x39 s5s6 D 68 N.s5s6.04
Polar ICL2 A 148 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 A 148 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 A 148 34x51 S16 Y 250 C.S16.03
Hydrophobic TM3 R 140 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 140 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 I 240 5x67 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 240 5x67 s15s16 F 245 C.s15s16.03
Ionic H8 K 373 8x49 s5s6 D 68 N.s5s6.04
Polar H8 K 376 8x52 s20c Q 407 C.s20c.17
Van-der-waals H8 K 376 8x52 s20c Q 407 C.s20c.17
Hydrophobic TM2 N 74 2x36 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 L 238 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 L 238 5x65 S6 F 76 N.S6.01
Hydrophobic TM5 F 246 5x73 s7s8 N 123 N.s7s8.05
Van-der-waals TM5 F 246 5x73 s7s8 N 123 N.s7s8.05
Hydrophobic TM4 T 153 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 T 153 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 T 244 5x71 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 T 244 5x71 s17s18 V 315 C.s17s18.40
Polar TM4 M 154 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 M 154 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 M 154 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 L 238 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 238 5x65 s5s6 L 74 N.s5s6.10
Polar TM6 R 307 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 307 6x29 s5s6 S 75 N.s5s6.11
Polar ICL3 R 296 - S6 I 82 N.S6.07
Van-der-waals ICL3 R 296 - S6 I 82 N.S6.07
Hydrophobic TM6 M 314 6x36 s5s6 L 72 N.s5s6.08
Polar TM5 G 243 5x70 S6 K 78 N.S6.03
Hydrophobic TM5 G 243 5x70 S6 K 78 N.S6.03
Van-der-waals TM5 G 243 5x70 S6 K 78 N.S6.03
Hydrophobic TM6 V 311 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 311 6x33 s5s6 L 74 N.s5s6.10
Polar H8 K 373 8x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 147 34x50 s5s6 G 65 N.s5s6.01
Hydrophobic TM5 G 243 5x70 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 G 243 5x70 s15s16 L 244 C.s15s16.02
Hydrophobic ICL2 R 150 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 150 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 147 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 147 34x50 S5 Y 64 N.S5.12
Polar H8 Q 372 8x48 s5s6 G 73 N.s5s6.09
Polar ICL2 A 148 34x51 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 148 34x51 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 F 246 5x73 s7s8 L 124 N.s7s8.06
Hydrophobic ICL2 P 147 34x50 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 R 245 5x72 S6 K 78 N.S6.03
Ionic ICL2 R 150 34x53 s5s6 D 68 N.s5s6.04
Polar ICL2 R 150 34x53 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 150 34x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 I 242 5x69 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 I 242 5x69 s15s16 F 245 C.s15s16.03
Ionic TM5 R 245 5x72 S6 D 79 N.S6.04
Polar TM5 R 245 5x72 S6 D 79 N.S6.04
Hydrophobic TM5 R 245 5x72 S6 D 79 N.S6.04
Van-der-waals TM5 R 245 5x72 S6 D 79 N.S6.04
Polar ICL2 P 147 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 147 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 147 34x50 s5s6 R 66 N.s5s6.02
Polar ICL2 N 149 34x52 S16 Y 250 C.S16.03
Hydrophobic ICL2 N 149 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 N 149 34x52 S16 Y 250 C.S16.03