Beta-arrestin-1 - GPR25 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR25 74.5
Beta-arrestin-1 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 L 145 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 145 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 145 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 144 34x50 S6 F 75 N.S6.01
Van-der-waals ICL2 L 144 34x50 S6 F 75 N.S6.01
Hydrophobic ICL2 L 145 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 145 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL1 R 71 12x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 R 71 12x51 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 R 72 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 L 229 5x65 S6 F 75 N.S6.01
Polar ICL3 G 236 - s5s6 T 74 N.s5s6.11
Van-der-waals ICL3 G 236 - s5s6 T 74 N.s5s6.11
Polar H8 R 312 8x48 s20c D 408 C.s20c.18
Van-der-waals H8 R 312 8x48 s20c D 408 C.s20c.18
Polar TM2 L 73 2x38 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 L 73 2x38 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 L 73 2x38 s5s6 D 67 N.s5s6.04
Polar TM3 K 143 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 K 143 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 K 143 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 144 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 144 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 I 246 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 246 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 V 235 - S6 F 75 N.S6.01
Van-der-waals ICL3 V 235 - S6 F 75 N.S6.01
Hydrophobic TM3 R 137 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 137 3x50 s5s6 V 70 N.s5s6.07
Polar ICL2 L 144 34x50 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 144 34x50 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 L 144 34x50 s5s6 R 65 N.s5s6.02
Hydrophobic ICL3 V 235 - s5s6 L 73 N.s5s6.10
Van-der-waals ICL3 V 235 - s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 145 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 145 34x51 S15 I 241 C.S15.14
Polar ICL2 L 145 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 145 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 145 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 148 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 148 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL3 P 233 - S6 K 77 N.S6.03
Van-der-waals ICL3 P 233 - S6 K 77 N.S6.03
Hydrophobic TM3 A 140 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL3 P 233 - S6 R 76 N.S6.02
Van-der-waals ICL3 P 233 - S6 R 76 N.S6.02
Hydrophobic TM6 A 238 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 A 238 6x29 s5s6 G 72 N.s5s6.09
Polar ICL2 R 148 34x54 S16 Y 249 C.S16.03
Hydrophobic ICL2 R 148 34x54 S16 Y 249 C.S16.03
Van-der-waals ICL2 R 148 34x54 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 144 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 V 235 - s5s6 T 74 N.s5s6.11
Van-der-waals ICL3 V 235 - s5s6 T 74 N.s5s6.11
Polar TM5 R 228 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 228 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM2 R 72 2x37 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 R 72 2x37 s5s6 E 66 N.s5s6.03
Polar TM6 S 242 6x33 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 S 242 6x33 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 S 242 6x33 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 R 72 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 72 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic ICL3 P 233 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 P 233 - s15s16 F 244 C.s15s16.03
Hydrophobic TM2 R 72 2x37 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 R 72 2x37 s5s6 V 70 N.s5s6.07
Polar TM6 R 239 6x30 s5s6 G 72 N.s5s6.09
Hydrophobic TM2 V 74 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 V 74 2x39 s5s6 V 70 N.s5s6.07
Polar ICL2 E 146 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 E 146 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 E 146 34x52 s15s16 N 245 C.s15s16.04
Polar ICL2 L 144 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 144 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 144 34x50 S5 Y 63 N.S5.12
Hydrophobic TM3 R 137 3x50 s5s6 L 71 N.s5s6.08
Ionic ICL2 R 148 34x54 s8s9 D 135 N.s8s9.06
Polar ICL2 R 148 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 R 148 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 148 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM6 R 239 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 R 239 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 V 141 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 141 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 R 148 34x54 s8s9 P 131 N.s8s9.02
Hydrophobic TM4 P 153 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM3 V 141 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 V 141 3x54 S6 F 75 N.S6.01
Polar TM6 S 242 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 S 242 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 242 6x33 s5s6 L 71 N.s5s6.08
Ionic ICL2 R 151 34x57 s5s6 D 67 N.s5s6.04
Polar ICL2 R 151 34x57 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 151 34x57 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 151 34x57 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 V 141 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 141 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 L 229 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 229 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 145 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 145 34x51 S16 A 247 C.S16.01
Hydrophobic TM3 V 141 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 V 141 3x54 s5s6 L 71 N.s5s6.08