ArrestinDb

Beta-arrestin-2 - GPR25 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
GPR25	75.7
Beta-arrestin-2	80.1

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.7

iPTM Score: 0.5

PAE mean: 17.1

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	TM6	I	246	6x37	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL3	P	233	-	s15s16	F	245	C.s15s16.03
Hydrophobic	TM3	R	137	3x50	s5s6	L	72	N.s5s6.08
Hydrophobic	C-term	C	349	-	s1s2	C	17	N.s1s2.04
Hydrophobic	ICL3	V	235	-	S6	F	76	N.S6.01
Hydrophobic	ICL3	V	235	-	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL2	L	144	34x50	s15s16	S	246	C.s15s16.04
Hydrophobic	ICL2	R	148	34x54	s8s9	G	138	N.s8s9.08
Hydrophobic	TM2	R	72	2x37	s5s6	E	67	N.s5s6.03
Hydrophobic	ICL2	L	144	34x50	S6	F	76	N.S6.01
Hydrophobic	TM3	R	137	3x50	s5s6	V	71	N.s5s6.07
Hydrophobic	TM2	R	72	2x37	s5s6	D	68	N.s5s6.04
Hydrophobic	TM2	V	74	2x39	s5s6	V	71	N.s5s6.07
Hydrophobic	TM6	R	239	6x30	s5s6	L	74	N.s5s6.10
Hydrophobic	C-term	D	342	-	S20	F	388	C.S20.03
Hydrophobic	C-term	F	347	-	S4	L	43	N.S4.06
Hydrophobic	ICL2	L	144	34x50	s15s16	F	245	C.s15s16.03
Hydrophobic	TM4	T	152	4x38	s8s9	T	137	N.s8s9.07
Hydrophobic	TM5	L	229	5x65	s5s6	L	74	N.s5s6.10
Hydrophobic	C-term	C	349	-	s1s2	N	16	N.s1s2.03
Hydrophobic	ICL3	P	233	-	S6	R	77	N.S6.02
Hydrophobic	C-term	F	347	-	S4	V	44	N.S4.07
Hydrophobic	ICL3	P	233	-	S6	K	78	N.S6.03
Hydrophobic	TM2	L	73	2x38	s8s9	T	137	N.s8s9.07
Hydrophobic	C-term	F	347	-	h1s7	H	112	N.h1s7.03
Hydrophobic	TM3	V	141	3x54	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL2	L	145	34x51	S16	A	248	C.S16.01
Hydrophobic	TM3	V	141	3x54	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	L	145	34x51	S5	Y	64	N.S5.12
Hydrophobic	ICL3	V	235	-	s5s6	S	75	N.s5s6.11
Hydrophobic	ICL2	L	145	34x51	s15s16	S	246	C.s15s16.04
Hydrophobic	C-term	V	346	-	H1	L	109	N.H1.10
Hydrophobic	C-term	R	331	-	s20c	Q	407	C.s20c.17
Hydrophobic	TM3	A	140	3x53	s5s6	L	69	N.s5s6.05
Hydrophobic	C-term	F	347	-	s4s5	D	45	N.s4s5.01
Hydrophobic	TM3	V	141	3x54	s5s6	L	69	N.s5s6.05
Hydrophobic	ICL2	L	145	34x51	s15s16	T	247	C.s15s16.05
Hydrophobic	TM6	A	238	6x29	s5s6	G	73	N.s5s6.09
Hydrophobic	TM3	V	141	3x54	S6	F	76	N.S6.01
Hydrophobic	TM6	I	245	6x36	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL2	R	148	34x54	S15	I	242	C.S15.14
Hydrophobic	C-term	D	342	-	H1	K	108	N.H1.09
Hydrophobic	ICL2	R	151	34x57	s8s9	T	137	N.s8s9.07
Hydrophobic	TM5	L	229	5x65	S6	F	76	N.S6.01
Hydrophobic	ICL2	L	144	34x50	S5	Y	64	N.S5.12
Hydrophobic	ICL2	R	148	34x54	S16	Y	250	C.S16.03
Hydrophobic	ICL2	L	145	34x51	S15	I	242	C.S15.14
Hydrophobic	TM6	S	242	6x33	s5s6	L	72	N.s5s6.08
Hydrophobic	C-term	V	346	-	S4	L	43	N.S4.06
Hydrophobic	TM2	R	72	2x37	s5s6	V	71	N.s5s6.07
Ionic	C-term	D	342	-	H1	K	108	N.H1.09
Polar	C-term	C	349	-	s1s2	C	17	N.s1s2.04
Polar	TM2	R	72	2x37	s5s6	E	67	N.s5s6.03
Polar	TM6	S	242	6x33	s5s6	V	71	N.s5s6.07
Polar	ICL2	E	146	34x52	s15s16	S	246	C.s15s16.04
Polar	C-term	C	349	-	s1s2	N	16	N.s1s2.03
Polar	TM5	R	228	5x64	s15s16	F	245	C.s15s16.03
Polar	TM3	K	143	3x56	s15s16	S	246	C.s15s16.04
Polar	TM1	R	67	1x60	s20c	Y	404	C.s20c.14
Polar	ICL2	L	145	34x51	S5	Y	64	N.S5.12
Polar	ICL2	L	145	34x51	s15s16	S	246	C.s15s16.04
Polar	C-term	R	331	-	s20c	Q	407	C.s20c.17
Polar	ICL3	G	236	-	s5s6	S	75	N.s5s6.11
Polar	C-term	D	342	-	H1	K	108	N.H1.09
Polar	ICL2	R	151	34x57	s8s9	T	137	N.s8s9.07
Polar	ICL2	R	148	34x54	S16	Y	250	C.S16.03
Polar	C-term	S	340	-	S1	K	11	N.S1.03
Polar	TM6	S	242	6x33	s5s6	L	72	N.s5s6.08
Polar	TM6	S	242	6x33	s5s6	G	73	N.s5s6.09
Van-der-waals	TM6	I	246	6x37	s5s6	L	72	N.s5s6.08
Van-der-waals	ICL3	P	233	-	s15s16	F	245	C.s15s16.03
Van-der-waals	C-term	C	349	-	s1s2	C	17	N.s1s2.04
Van-der-waals	ICL3	V	235	-	S6	F	76	N.S6.01
Van-der-waals	ICL3	V	235	-	s5s6	L	74	N.s5s6.10
Van-der-waals	ICL2	L	144	34x50	s15s16	S	246	C.s15s16.04
Van-der-waals	ICL2	R	148	34x54	s8s9	G	138	N.s8s9.08
Van-der-waals	ICL2	L	144	34x50	S6	F	76	N.S6.01
Van-der-waals	TM3	R	137	3x50	s5s6	V	71	N.s5s6.07
Van-der-waals	TM2	R	72	2x37	s5s6	D	68	N.s5s6.04
Van-der-waals	ICL2	R	148	34x54	S16	A	248	C.S16.01
Van-der-waals	TM2	V	74	2x39	s5s6	V	71	N.s5s6.07
Van-der-waals	TM6	R	239	6x30	s5s6	L	74	N.s5s6.10
Van-der-waals	C-term	D	342	-	S20	F	388	C.S20.03
Van-der-waals	C-term	F	347	-	S4	L	43	N.S4.06
Van-der-waals	ICL2	L	144	34x50	s15s16	F	245	C.s15s16.03
Van-der-waals	TM5	L	229	5x65	s5s6	L	74	N.s5s6.10
Van-der-waals	C-term	C	349	-	s1s2	N	16	N.s1s2.03
Van-der-waals	TM5	R	228	5x64	s15s16	F	245	C.s15s16.03
Van-der-waals	ICL3	P	233	-	S6	R	77	N.S6.02
Van-der-waals	C-term	F	347	-	S4	V	44	N.S4.07
Van-der-waals	ICL3	P	233	-	S6	K	78	N.S6.03
Van-der-waals	TM3	V	141	3x54	s5s6	L	74	N.s5s6.10
Van-der-waals	ICL2	L	145	34x51	S16	A	248	C.S16.01
Van-der-waals	ICL2	L	145	34x51	S5	Y	64	N.S5.12
Van-der-waals	ICL3	V	235	-	s5s6	S	75	N.s5s6.11
Van-der-waals	ICL2	L	145	34x51	s15s16	S	246	C.s15s16.04
Van-der-waals	C-term	R	331	-	s20c	Q	407	C.s20c.17
Van-der-waals	TM3	A	140	3x53	s5s6	L	69	N.s5s6.05
Van-der-waals	C-term	F	347	-	s4s5	D	45	N.s4s5.01
Van-der-waals	ICL3	G	236	-	s5s6	S	75	N.s5s6.11
Van-der-waals	TM3	V	141	3x54	s5s6	L	69	N.s5s6.05
Van-der-waals	TM6	A	238	6x29	s5s6	G	73	N.s5s6.09
Van-der-waals	TM3	V	141	3x54	S6	F	76	N.S6.01
Van-der-waals	TM6	I	245	6x36	s5s6	V	71	N.s5s6.07
Van-der-waals	C-term	D	342	-	H1	K	108	N.H1.09
Van-der-waals	ICL2	R	151	34x57	s8s9	T	137	N.s8s9.07
Van-der-waals	ICL2	L	144	34x50	S5	Y	64	N.S5.12
Van-der-waals	ICL2	R	148	34x54	S16	Y	250	C.S16.03
Van-der-waals	ICL3	H	234	-	S6	R	77	N.S6.02
Van-der-waals	ICL2	L	145	34x51	S15	I	242	C.S15.14
Van-der-waals	TM6	S	242	6x33	s5s6	L	72	N.s5s6.08
Van-der-waals	C-term	V	346	-	S4	L	43	N.S4.06

Showing 1 to 112 of 112 entries

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Main reference

Beta-arrestin-2 - GPR25 complex model Download Full