S-arrestin - GPR25 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR25 72.0
S-arrestin 80.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM6 R 237 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 R 237 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 R 237 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 237 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 V 235 - S6 F 83 N.S6.01
Hydrophobic TM5 R 228 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 228 5x64 s15s16 Y 254 C.s15s16.03
Ionic TM6 R 240 6x31 s9s10 E 164 N.s9s10.06
Hydrophobic H8 D 311 8x47 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 V 74 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 V 74 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 V 141 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 R 137 3x50 s5s6 I 79 N.s5s6.08
Polar TM6 S 242 6x33 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 S 242 6x33 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 S 242 6x33 s5s6 V 78 N.s5s6.07
Polar TM2 R 72 2x37 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 R 72 2x37 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 R 72 2x37 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 S 242 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 S 242 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 R 239 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 R 239 6x30 s5s6 L 81 N.s5s6.10
Polar ICL2 R 148 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 R 148 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 R 148 34x54 S5 Y 71 N.S5.12
Hydrophobic TM6 I 246 6x37 s5s6 I 79 N.s5s6.08
Polar ICL3 G 236 - S6 R 84 N.S6.02
Hydrophobic ICL3 G 236 - S6 R 84 N.S6.02
Van-der-waals ICL3 G 236 - S6 R 84 N.S6.02
Hydrophobic TM3 M 133 3x46 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 P 233 - S6 D 86 N.S6.04
Van-der-waals ICL3 P 233 - S6 D 86 N.S6.04
Hydrophobic TM6 A 238 6x29 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 A 238 6x29 s5s6 G 80 N.s5s6.09
Ionic TM6 R 237 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 237 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 237 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 237 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM3 R 137 3x50 s5s6 V 78 N.s5s6.07
Polar TM6 S 242 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 S 242 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 S 242 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 V 235 - S6 R 84 N.S6.02
Van-der-waals ICL3 V 235 - S6 R 84 N.S6.02
Hydrophobic ICL2 L 145 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 L 145 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic TM7 Y 307 7x53 s5s6 I 79 N.s5s6.08
Polar ICL2 R 148 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 148 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 148 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 L 145 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 145 34x51 S5 Y 71 N.S5.12
Polar ICL3 H 234 - S6 D 86 N.S6.04
Van-der-waals ICL3 V 235 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM2 V 78 2x43 s5s6 I 79 N.s5s6.08
Polar ICL2 L 145 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 L 145 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 L 145 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 A 238 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 A 238 6x29 s5s6 T 82 N.s5s6.11
Polar TM6 R 239 6x30 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 L 145 34x51 S15 V 251 C.S15.14
Hydrophobic TM3 A 140 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 140 3x53 S6 F 83 N.S6.01
Hydrophobic TM3 V 141 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 141 3x54 S6 F 83 N.S6.01
Hydrophobic ICL3 V 235 - S6 R 85 N.S6.03
Aromatic TM6 R 239 6x30 S6 F 83 N.S6.01
Hydrophobic TM6 R 239 6x30 S6 F 83 N.S6.01
Van-der-waals TM6 R 239 6x30 S6 F 83 N.S6.01
Hydrophobic TM6 L 243 6x34 s5s6 L 81 N.s5s6.10
Polar TM6 R 239 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic TM2 V 74 2x39 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 V 74 2x39 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 R 239 6x30 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 R 239 6x30 s5s6 T 82 N.s5s6.11
Hydrophobic H8 S 313 8x49 s5s6 D 77 N.s5s6.06
Polar TM6 S 242 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 S 242 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 S 242 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 144 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 L 144 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM2 R 72 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 R 72 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 L 144 34x50 S6 F 83 N.S6.01
Van-der-waals ICL2 L 144 34x50 S6 F 83 N.S6.01
Hydrophobic ICL3 P 233 - S6 R 85 N.S6.03
Van-der-waals ICL3 P 233 - S6 R 85 N.S6.03
Polar ICL2 R 148 34x54 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 148 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 148 34x54 S16 Y 259 C.S16.03
Ionic ICL2 R 148 34x54 S16 D 257 C.S16.01
Polar ICL2 R 148 34x54 S16 D 257 C.S16.01
Hydrophobic ICL2 R 148 34x54 S16 D 257 C.S16.01
Van-der-waals ICL2 R 148 34x54 S16 D 257 C.S16.01
Hydrophobic ICL2 L 145 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 145 34x51 S16 D 257 C.S16.01
Hydrophobic TM6 R 237 6x28 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 237 6x28 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 I 245 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 245 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 137 3x50 s5s6 L 81 N.s5s6.10