G13 - GPR26 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPR26 86.9
subunit alpha-13 83.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
01
iPTM Score: 0.8
01
PAE mean: 14.1
031


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:
K02R03G.hns1R16G.H4Q12Q13G.h4s6D10D13H17G.H5GproteinA34x55R5x71H5x68T-R2x36R6x29GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.H4G.h4s6G.H5GPCR segments:TM2ICL2ICL3TM5TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x363x503x533x5434x5034x5134x5434x554x385x645x655x685x715x725x755x766x296x326x336x367x568x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.11G.H5.10G.H5.09G.H5.08G.S6.02G.S6.01G.h4s6.20G.h4s6.13G.h4s6.12G.H4.16G.H4.09G.S3.03G.S3.01G.S1.02G.hns1.03G.hns1.02Res. Pos.GPR26 (AFM_GPR26_HUMAN_GNA13_HUMAN)- (AFM_GPR26_HUMAN_GNA13_HUMAN)------------------------RRAVPLRARVAHRIITRRAKLRHRPLRARAVRVAHRIITRRAKLRHVKKILFVVVFRLNLDHRDPLYMQQQLKR

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.