Beta-arrestin-1 - GPR31 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR31 75.9
Beta-arrestin-1 80.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 116 3x54 s5s6 L 68 N.s5s6.05
Polar ICL2 R 120 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 120 34x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 120 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 R 207 5x68 S6 F 75 N.S6.01
Hydrophobic TM7 F 284 7x55 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 F 284 7x55 s5s6 V 70 N.s5s6.07
Ionic TM2 K 47 2x37 s5s6 E 66 N.s5s6.03
Polar TM2 K 47 2x37 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 K 47 2x37 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 K 47 2x37 s5s6 E 66 N.s5s6.03
Polar C-term Y 318 - s5s6 R 65 N.s5s6.02
Aromatic C-term Y 318 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term Y 318 - s5s6 R 65 N.s5s6.02
Van-der-waals C-term Y 318 - s5s6 R 65 N.s5s6.02
Polar TM7 S 285 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic TM7 S 285 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 S 285 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic H8 P 287 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 P 287 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 V 224 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 224 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic C-term R 315 - s20c K 403 C.s20c.13
Van-der-waals C-term R 315 - s20c K 403 C.s20c.13
Hydrophobic TM2 Y 49 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 Y 49 2x39 s5s6 V 70 N.s5s6.07
Polar C-term Y 318 - s20c E 407 C.s20c.17
Hydrophobic C-term Y 318 - s20c E 407 C.s20c.17
Van-der-waals C-term Y 318 - s20c E 407 C.s20c.17
Polar C-term S 319 - s20c D 408 C.s20c.18
Hydrophobic C-term S 319 - s20c D 408 C.s20c.18
Van-der-waals C-term S 319 - s20c D 408 C.s20c.18
Hydrophobic ICL2 P 119 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 119 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 120 34x51 S16 A 247 C.S16.01
Hydrophobic TM6 K 216 6x29 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 K 216 6x29 s5s6 L 73 N.s5s6.10
Polar C-term Y 318 - s5s6 D 69 N.s5s6.06
Hydrophobic C-term R 315 - s20c E 407 C.s20c.17
Van-der-waals C-term R 315 - s20c E 407 C.s20c.17
Hydrophobic C-term Y 318 - s5s6 T 74 N.s5s6.11
Van-der-waals C-term Y 318 - s5s6 T 74 N.s5s6.11
Hydrophobic TM3 R 115 3x53 s5s6 V 70 N.s5s6.07
Polar TM7 F 284 7x55 s5s6 L 71 N.s5s6.08
Hydrophobic C-term P 309 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term P 309 - s9s10 R 161 N.s9s10.13
Polar C-term D 316 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term D 316 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term D 316 - s20c E 407 C.s20c.17
Van-der-waals C-term D 316 - s20c E 407 C.s20c.17
Polar TM6 Q 214 6x27 S6 R 76 N.S6.02
Polar C-term S 317 - s20c E 407 C.s20c.17
Hydrophobic C-term S 317 - s20c E 407 C.s20c.17
Van-der-waals C-term S 317 - s20c E 407 C.s20c.17
Polar H8 R 290 8x51 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 V 116 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 204 5x65 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 L 208 - S6 F 75 N.S6.01
Hydrophobic TM3 R 112 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic H8 P 287 8x48 s5s6 G 72 N.s5s6.09
Hydrophobic C-term F 312 - s9s10 K 160 N.s9s10.12
Hydrophobic ICL2 L 125 34x56 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 L 125 34x56 s8s9 D 135 N.s8s9.06
Van-der-waals C-term Y 318 - s20c E 405 C.s20c.15
Polar C-term S 319 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term S 319 - s9s10 K 160 N.s9s10.12
Polar TM5 R 207 5x68 s15s16 F 244 C.s15s16.03
Aromatic TM5 R 207 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 207 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 207 5x68 s15s16 F 244 C.s15s16.03
Polar C-term S 319 - S10 R 165 N.S10.03
Hydrophobic C-term S 319 - S10 R 165 N.S10.03
Van-der-waals C-term S 319 - S10 R 165 N.S10.03
Hydrophobic TM6 L 217 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 I 200 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 K 122 34x53 s8s9 T 136 N.s8s9.07
Polar C-term S 319 - s20c E 407 C.s20c.17
Hydrophobic C-term S 319 - s20c E 407 C.s20c.17
Van-der-waals C-term S 319 - s20c E 407 C.s20c.17
Polar ICL2 R 120 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 120 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 120 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 A 220 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 220 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 A 220 6x33 s5s6 L 71 N.s5s6.08
Polar TM3 R 112 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 112 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 112 3x50 s5s6 V 70 N.s5s6.07
Polar C-term S 317 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term S 317 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term S 317 - s9s10 K 160 N.s9s10.12
Polar TM6 K 216 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 L 125 34x56 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 L 125 34x56 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 L 204 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 204 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic C-term D 316 - s20c G 409 C.s20c.19
Polar ICL2 R 120 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 R 120 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 R 120 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 L 204 5x65 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 125 34x56 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 L 125 34x56 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 L 121 34x52 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 L 121 34x52 s8s9 T 136 N.s8s9.07
Ionic TM3 R 115 3x53 s5s6 D 67 N.s5s6.04
Polar TM3 R 115 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 R 115 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 R 115 3x53 s5s6 D 67 N.s5s6.04
Polar ICL2 P 119 34x50 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 P 119 34x50 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 P 119 34x50 s8s9 T 136 N.s8s9.07