ArrestinDb

Beta-arrestin-1 - GPR31 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
GPR31	75.9
Beta-arrestin-1	80.5

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 19.4

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	C-term	Y	318	-	s5s6	R	65	N.s5s6.02
Aromatic	TM5	R	207	5x68	s15s16	F	244	C.s15s16.03
Hydrophobic	TM3	V	116	3x54	s5s6	L	68	N.s5s6.05
Hydrophobic	ICL2	R	120	34x51	s8s9	T	136	N.s8s9.07
Hydrophobic	TM5	R	207	5x68	S6	F	75	N.S6.01
Hydrophobic	TM7	F	284	7x55	s5s6	V	70	N.s5s6.07
Hydrophobic	TM2	K	47	2x37	s5s6	E	66	N.s5s6.03
Hydrophobic	C-term	Y	318	-	s5s6	R	65	N.s5s6.02
Hydrophobic	TM7	S	285	7x56	s5s6	V	70	N.s5s6.07
Hydrophobic	H8	P	287	8x48	s5s6	D	69	N.s5s6.06
Hydrophobic	TM6	V	224	6x37	s5s6	L	71	N.s5s6.08
Hydrophobic	C-term	R	315	-	s20c	K	403	C.s20c.13
Hydrophobic	TM2	Y	49	2x39	s5s6	V	70	N.s5s6.07
Hydrophobic	C-term	Y	318	-	s20c	E	407	C.s20c.17
Hydrophobic	C-term	S	319	-	s20c	D	408	C.s20c.18
Hydrophobic	ICL2	P	119	34x50	s15s16	N	245	C.s15s16.04
Hydrophobic	ICL2	R	120	34x51	S16	A	247	C.S16.01
Hydrophobic	TM6	K	216	6x29	s5s6	L	73	N.s5s6.10
Hydrophobic	C-term	R	315	-	s20c	E	407	C.s20c.17
Hydrophobic	C-term	Y	318	-	s5s6	T	74	N.s5s6.11
Hydrophobic	TM3	R	115	3x53	s5s6	V	70	N.s5s6.07
Hydrophobic	C-term	P	309	-	s9s10	R	161	N.s9s10.13
Hydrophobic	C-term	D	316	-	s20c	E	407	C.s20c.17
Hydrophobic	C-term	S	317	-	s20c	E	407	C.s20c.17
Hydrophobic	TM3	V	116	3x54	s5s6	L	71	N.s5s6.08
Hydrophobic	TM5	L	204	5x65	s5s6	L	71	N.s5s6.08
Hydrophobic	ICL3	L	208	-	S6	F	75	N.S6.01
Hydrophobic	TM3	R	112	3x50	s5s6	L	71	N.s5s6.08
Hydrophobic	H8	P	287	8x48	s5s6	G	72	N.s5s6.09
Hydrophobic	C-term	F	312	-	s9s10	K	160	N.s9s10.12
Hydrophobic	ICL2	L	125	34x56	s8s9	D	135	N.s8s9.06
Hydrophobic	TM5	R	207	5x68	s15s16	F	244	C.s15s16.03
Hydrophobic	C-term	S	319	-	S10	R	165	N.S10.03
Hydrophobic	TM6	L	217	6x30	s5s6	L	73	N.s5s6.10
Hydrophobic	TM5	I	200	5x61	s5s6	L	71	N.s5s6.08
Hydrophobic	ICL2	K	122	34x53	s8s9	T	136	N.s8s9.07
Hydrophobic	C-term	S	319	-	s20c	E	407	C.s20c.17
Hydrophobic	ICL2	R	120	34x51	s15s16	N	245	C.s15s16.04
Hydrophobic	TM6	A	220	6x33	s5s6	L	73	N.s5s6.10
Hydrophobic	TM6	A	220	6x33	s5s6	L	71	N.s5s6.08
Hydrophobic	TM3	R	112	3x50	s5s6	V	70	N.s5s6.07
Hydrophobic	C-term	S	317	-	s9s10	K	160	N.s9s10.12
Hydrophobic	ICL2	L	125	34x56	s8s9	E	134	N.s8s9.05
Hydrophobic	TM5	L	204	5x65	s5s6	L	73	N.s5s6.10
Hydrophobic	C-term	D	316	-	s20c	G	409	C.s20c.19
Hydrophobic	ICL2	R	120	34x51	s15s16	T	246	C.s15s16.05
Hydrophobic	TM5	L	204	5x65	s5s6	L	68	N.s5s6.05
Hydrophobic	ICL2	L	125	34x56	s8s9	T	136	N.s8s9.07
Hydrophobic	ICL2	L	121	34x52	s8s9	T	136	N.s8s9.07
Hydrophobic	TM3	R	115	3x53	s5s6	D	67	N.s5s6.04
Hydrophobic	ICL2	P	119	34x50	s8s9	T	136	N.s8s9.07
Ionic	TM2	K	47	2x37	s5s6	E	66	N.s5s6.03
Ionic	TM3	R	115	3x53	s5s6	D	67	N.s5s6.04
Polar	ICL2	R	120	34x51	s8s9	T	136	N.s8s9.07
Polar	TM2	K	47	2x37	s5s6	E	66	N.s5s6.03
Polar	C-term	Y	318	-	s5s6	R	65	N.s5s6.02
Polar	TM7	S	285	7x56	s5s6	V	70	N.s5s6.07
Polar	C-term	Y	318	-	s20c	E	407	C.s20c.17
Polar	C-term	S	319	-	s20c	D	408	C.s20c.18
Polar	C-term	Y	318	-	s5s6	D	69	N.s5s6.06
Polar	TM7	F	284	7x55	s5s6	L	71	N.s5s6.08
Polar	C-term	D	316	-	s9s10	K	160	N.s9s10.12
Polar	TM6	Q	214	6x27	S6	R	76	N.S6.02
Polar	C-term	S	317	-	s20c	E	407	C.s20c.17
Polar	H8	R	290	8x51	s5s6	L	71	N.s5s6.08
Polar	C-term	S	319	-	s9s10	K	160	N.s9s10.12
Polar	TM5	R	207	5x68	s15s16	F	244	C.s15s16.03
Polar	C-term	S	319	-	S10	R	165	N.S10.03
Polar	C-term	S	319	-	s20c	E	407	C.s20c.17
Polar	ICL2	R	120	34x51	s15s16	N	245	C.s15s16.04
Polar	TM3	R	112	3x50	s5s6	V	70	N.s5s6.07
Polar	C-term	S	317	-	s9s10	K	160	N.s9s10.12
Polar	TM6	K	216	6x29	s5s6	T	74	N.s5s6.11
Polar	ICL2	R	120	34x51	s15s16	T	246	C.s15s16.05
Polar	TM3	R	115	3x53	s5s6	D	67	N.s5s6.04
Polar	ICL2	P	119	34x50	s8s9	T	136	N.s8s9.07
Van-der-waals	ICL2	R	120	34x51	s8s9	T	136	N.s8s9.07
Van-der-waals	TM7	F	284	7x55	s5s6	V	70	N.s5s6.07
Van-der-waals	TM2	K	47	2x37	s5s6	E	66	N.s5s6.03
Van-der-waals	C-term	Y	318	-	s5s6	R	65	N.s5s6.02
Van-der-waals	TM7	S	285	7x56	s5s6	V	70	N.s5s6.07
Van-der-waals	H8	P	287	8x48	s5s6	D	69	N.s5s6.06
Van-der-waals	TM6	V	224	6x37	s5s6	L	71	N.s5s6.08
Van-der-waals	C-term	R	315	-	s20c	K	403	C.s20c.13
Van-der-waals	TM2	Y	49	2x39	s5s6	V	70	N.s5s6.07
Van-der-waals	C-term	Y	318	-	s20c	E	407	C.s20c.17
Van-der-waals	C-term	S	319	-	s20c	D	408	C.s20c.18
Van-der-waals	ICL2	P	119	34x50	s15s16	N	245	C.s15s16.04
Van-der-waals	TM6	K	216	6x29	s5s6	L	73	N.s5s6.10
Van-der-waals	C-term	R	315	-	s20c	E	407	C.s20c.17
Van-der-waals	C-term	Y	318	-	s5s6	T	74	N.s5s6.11
Van-der-waals	C-term	P	309	-	s9s10	R	161	N.s9s10.13
Van-der-waals	C-term	D	316	-	s9s10	K	160	N.s9s10.12
Van-der-waals	C-term	D	316	-	s20c	E	407	C.s20c.17
Van-der-waals	C-term	S	317	-	s20c	E	407	C.s20c.17
Van-der-waals	ICL2	L	125	34x56	s8s9	D	135	N.s8s9.06
Van-der-waals	C-term	Y	318	-	s20c	E	405	C.s20c.15
Van-der-waals	C-term	S	319	-	s9s10	K	160	N.s9s10.12
Van-der-waals	TM5	R	207	5x68	s15s16	F	244	C.s15s16.03
Van-der-waals	C-term	S	319	-	S10	R	165	N.S10.03
Van-der-waals	C-term	S	319	-	s20c	E	407	C.s20c.17
Van-der-waals	ICL2	R	120	34x51	s15s16	N	245	C.s15s16.04
Van-der-waals	TM6	A	220	6x33	s5s6	L	73	N.s5s6.10
Van-der-waals	TM3	R	112	3x50	s5s6	V	70	N.s5s6.07
Van-der-waals	C-term	S	317	-	s9s10	K	160	N.s9s10.12
Van-der-waals	ICL2	L	125	34x56	s8s9	E	134	N.s8s9.05
Van-der-waals	TM5	L	204	5x65	s5s6	L	73	N.s5s6.10
Van-der-waals	ICL2	R	120	34x51	s15s16	T	246	C.s15s16.05
Van-der-waals	ICL2	L	125	34x56	s8s9	T	136	N.s8s9.07
Van-der-waals	ICL2	L	121	34x52	s8s9	T	136	N.s8s9.07
Van-der-waals	TM3	R	115	3x53	s5s6	D	67	N.s5s6.04
Van-der-waals	ICL2	P	119	34x50	s8s9	T	136	N.s8s9.07

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Main reference

Beta-arrestin-1 - GPR31 complex model Download Full