Beta-arrestin-2 - GPR31 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR31 74.5
Beta-arrestin-2 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 V 116 3x54 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 V 116 3x54 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 V 116 3x54 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 N 124 34x55 s8s9 T 137 N.s8s9.07
Hydrophobic C-term Y 318 - s17s18 K 295 C.s17s18.20
Van-der-waals C-term Y 318 - s17s18 K 295 C.s17s18.20
Hydrophobic TM6 L 223 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 224 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic C-term F 312 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term F 312 - s9s10 K 161 N.s9s10.12
Ionic TM2 K 47 2x37 s5s6 E 67 N.s5s6.03
Polar TM2 K 47 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 K 47 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 K 47 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 R 115 3x53 s5s6 V 71 N.s5s6.07
Polar C-term S 319 - S1 K 12 N.S1.04
Hydrophobic C-term S 319 - S1 K 12 N.S1.04
Van-der-waals C-term S 319 - S1 K 12 N.S1.04
Hydrophobic TM3 V 116 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 V 116 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 L 208 - S6 F 76 N.S6.01
Van-der-waals ICL3 L 208 - S6 F 76 N.S6.01
Hydrophobic TM3 R 112 3x50 s5s6 L 72 N.s5s6.08
Polar TM6 K 216 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 K 216 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 K 216 6x29 s5s6 S 75 N.s5s6.11
Polar ICL2 R 120 34x51 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 R 120 34x51 s15s16 T 247 C.s15s16.05
Hydrophobic TM2 Y 49 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 204 5x65 s5s6 L 74 N.s5s6.10
Ionic ICL3 R 209 - s17s18 E 314 C.s17s18.39
Polar ICL3 R 209 - s17s18 E 314 C.s17s18.39
Ionic ICL1 R 44 12x49 s20c D 403 C.s20c.13
Polar ICL1 R 44 12x49 s20c D 403 C.s20c.13
Van-der-waals ICL1 R 44 12x49 s20c D 403 C.s20c.13
Hydrophobic TM3 R 115 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 115 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 P 119 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 119 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 125 34x56 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 L 125 34x56 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 Q 214 6x27 S6 F 76 N.S6.01
Van-der-waals TM6 Q 214 6x27 S6 F 76 N.S6.01
Hydrophobic TM6 A 220 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 220 6x33 s5s6 L 74 N.s5s6.10
Polar ICL2 P 119 34x50 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 119 34x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 P 119 34x50 s8s9 T 137 N.s8s9.07
Polar C-term Y 318 - s20c D 401 C.s20c.11
Hydrophobic C-term Y 318 - s20c D 401 C.s20c.11
Polar TM3 R 112 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 112 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 112 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 125 34x56 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 L 125 34x56 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 L 204 5x65 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 200 5x61 s5s6 L 72 N.s5s6.08
Polar TM5 R 207 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 207 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 207 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 L 208 - s15s16 F 245 C.s15s16.03
Hydrophobic TM6 A 220 6x33 s5s6 L 72 N.s5s6.08
Ionic TM5 R 207 5x68 s5s6 D 68 N.s5s6.04
Polar TM5 R 207 5x68 s5s6 D 68 N.s5s6.04
Hydrophobic TM7 S 285 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 S 285 7x56 s5s6 V 71 N.s5s6.07
Aromatic C-term Y 318 - s20c R 395 C.s20c.05
Hydrophobic C-term Y 318 - s20c R 395 C.s20c.05
Van-der-waals C-term Y 318 - s20c R 395 C.s20c.05
Van-der-waals TM5 R 207 5x68 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 K 216 6x29 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 K 216 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 125 34x56 s8s9 D 136 N.s8s9.06
Hydrophobic TM6 L 217 6x30 s5s6 L 74 N.s5s6.10
Ionic TM3 R 115 3x53 s5s6 E 67 N.s5s6.03
Polar TM3 R 115 3x53 s5s6 E 67 N.s5s6.03
Van-der-waals TM3 R 115 3x53 s5s6 E 67 N.s5s6.03
Hydrophobic TM5 L 204 5x65 s5s6 L 69 N.s5s6.05