Gt1 - GPR31 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR31 77.3
Gαt1 87.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 120 34x51 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 R 120 34x51 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 R 120 34x51 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 L 121 34x52 G.hns1 A 27 G.hns1.02
Hydrophobic TM5 R 207 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 R 207 5x68 G.H5 I 340 G.H5.16
Hydrophobic ICL2 R 120 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 R 120 34x51 G.S3 L 190 G.S3.01
Hydrophobic TM5 L 204 5x65 G.H5 L 344 G.H5.20
Hydrophobic TM2 Y 49 2x39 G.H5 G 348 G.H5.24
Polar ICL2 R 120 34x51 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 R 120 34x51 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 R 120 34x51 G.hns1 R 28 G.hns1.03
Polar ICL2 R 120 34x51 G.s2s3 D 189 G.s2s3.02
Hydrophobic ICL2 R 120 34x51 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 R 120 34x51 G.s2s3 D 189 G.s2s3.02
Polar ICL2 R 120 34x51 G.S3 N 191 G.S3.02
Hydrophobic ICL2 R 120 34x51 G.S3 N 191 G.S3.02
Van-der-waals ICL2 R 120 34x51 G.S3 N 191 G.S3.02
Hydrophobic TM6 A 220 6x33 G.H5 L 344 G.H5.20
Hydrophobic TM6 L 217 6x30 G.H5 F 350 G.H5.26
Hydrophobic TM6 V 224 6x37 G.H5 L 349 G.H5.25
Van-der-waals TM6 V 224 6x37 G.H5 L 349 G.H5.25
Ionic TM3 R 115 3x53 G.H5 D 346 G.H5.22
Hydrophobic TM3 R 115 3x53 G.H5 D 346 G.H5.22
Hydrophobic H8 P 287 8x48 G.H5 F 350 G.H5.26
Van-der-waals H8 P 287 8x48 G.H5 F 350 G.H5.26
Polar H8 S 286 8x47 G.H5 G 348 G.H5.24
Hydrophobic TM3 V 116 3x54 G.H5 N 343 G.H5.19
Hydrophobic TM2 Y 49 2x39 G.H5 D 346 G.H5.22
Van-der-waals TM2 Y 49 2x39 G.H5 D 346 G.H5.22
Polar ICL2 K 122 34x53 G.HN L 19 G.HN.47
Hydrophobic ICL2 P 119 34x50 G.S3 L 190 G.S3.01
Van-der-waals TM3 R 112 3x50 G.H5 C 347 G.H5.23
Polar TM3 R 112 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM2 Y 49 2x39 G.H5 C 347 G.H5.23
Polar ICL2 K 122 34x53 G.HN K 20 G.HN.48
Hydrophobic ICL2 K 122 34x53 G.HN K 20 G.HN.48
Van-der-waals ICL2 K 122 34x53 G.HN K 20 G.HN.48
Hydrophobic TM6 L 217 6x30 G.H5 L 344 G.H5.20
Van-der-waals TM6 L 217 6x30 G.H5 L 344 G.H5.20
Ionic TM5 K 206 5x67 G.s2s3 D 189 G.s2s3.02
Polar TM5 K 206 5x67 G.s2s3 D 189 G.s2s3.02
Van-der-waals TM5 K 206 5x67 G.s2s3 D 189 G.s2s3.02
Polar ICL3 R 209 - G.H5 F 330 G.H5.06
Aromatic ICL3 R 209 - G.H5 F 330 G.H5.06
Hydrophobic ICL3 R 209 - G.H5 F 330 G.H5.06
Van-der-waals ICL3 R 209 - G.H5 F 330 G.H5.06
Hydrophobic ICL2 P 119 34x50 G.H5 N 343 G.H5.19
Polar ICL3 R 209 - G.H5 D 337 G.H5.13
Hydrophobic ICL3 R 209 - G.H5 D 337 G.H5.13
Van-der-waals ICL3 R 209 - G.H5 D 337 G.H5.13
Hydrophobic TM6 A 220 6x33 G.H5 L 349 G.H5.25
Hydrophobic TM3 R 115 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 115 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM3 V 116 3x54 G.H5 C 347 G.H5.23
Hydrophobic TM3 V 116 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 V 116 3x54 G.H5 L 344 G.H5.20
Ionic ICL3 R 209 - G.H5 D 333 G.H5.09
Polar ICL3 R 209 - G.H5 D 333 G.H5.09
Hydrophobic ICL3 R 209 - G.H5 D 333 G.H5.09
Van-der-waals ICL3 R 209 - G.H5 D 333 G.H5.09
Hydrophobic TM6 K 216 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 K 216 6x29 G.H5 F 350 G.H5.26
Hydrophobic ICL2 K 122 34x53 G.HN A 23 G.HN.51
Van-der-waals ICL2 K 122 34x53 G.HN A 23 G.HN.51
Hydrophobic TM5 L 204 5x65 G.H5 I 340 G.H5.16
Van-der-waals TM5 L 204 5x65 G.H5 I 340 G.H5.16
Hydrophobic TM6 L 223 6x36 G.H5 L 349 G.H5.25
Polar TM5 R 207 5x68 G.s2s3 K 188 G.s2s3.01
Hydrophobic TM5 R 207 5x68 G.s2s3 K 188 G.s2s3.01
Van-der-waals TM5 R 207 5x68 G.s2s3 K 188 G.s2s3.01
Ionic TM2 K 47 2x37 G.H5 D 346 G.H5.22
Polar TM2 K 47 2x37 G.H5 D 346 G.H5.22
Hydrophobic TM2 K 47 2x37 G.H5 D 346 G.H5.22
Van-der-waals TM2 K 47 2x37 G.H5 D 346 G.H5.22
Polar TM6 Q 214 6x27 G.H5 K 341 G.H5.17
Hydrophobic TM6 Q 214 6x27 G.H5 K 341 G.H5.17
Van-der-waals TM6 Q 214 6x27 G.H5 K 341 G.H5.17
Polar TM6 Q 214 6x27 G.H5 D 337 G.H5.13
Van-der-waals TM6 Q 214 6x27 G.H5 D 337 G.H5.13
Hydrophobic TM3 R 112 3x50 G.H5 L 349 G.H5.25
Van-der-waals TM3 R 112 3x50 G.H5 L 349 G.H5.25
Polar TM3 R 115 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 R 115 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 R 115 3x53 G.H5 N 343 G.H5.19
Hydrophobic ICL3 L 208 - G.H5 D 337 G.H5.13
Van-der-waals ICL3 L 208 - G.H5 D 337 G.H5.13
Hydrophobic ICL3 L 208 - G.H5 I 340 G.H5.16
Van-der-waals ICL3 L 208 - G.H5 I 340 G.H5.16
Hydrophobic ICL2 K 122 34x53 G.HN E 24 G.HN.52