Beta-arrestin-2 - GPR32 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR32 79.3
Beta-arrestin-2 82.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 F 81 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic C-term P 349 - s1s2 C 17 N.s1s2.04
Polar C-term C 348 - s1s2 C 17 N.s1s2.04
Hydrophobic C-term C 348 - s1s2 C 17 N.s1s2.04
Van-der-waals C-term C 348 - s1s2 C 17 N.s1s2.04
Hydrophobic ICL2 V 147 34x51 S16 A 248 C.S16.01
Polar TM2 S 77 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 77 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 W 248 - S6 F 76 N.S6.01
Van-der-waals ICL3 W 248 - S6 F 76 N.S6.01
Hydrophobic TM1 M 72 1x61 s5s6 E 67 N.s5s6.03
Van-der-waals TM1 M 72 1x61 s5s6 E 67 N.s5s6.03
Polar TM4 V 155 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 V 155 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 V 155 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 W 248 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 W 248 - s5s6 L 74 N.s5s6.10
Hydrophobic TM5 I 239 5x61 s5s6 L 72 N.s5s6.08
Ionic ICL2 R 153 34x57 s8s9 D 136 N.s8s9.06
Polar ICL2 R 153 34x57 s8s9 D 136 N.s8s9.06
Polar H8 D 322 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 D 322 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 D 322 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic TM5 I 239 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 P 254 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 P 254 6x33 s5s6 G 73 N.s5s6.09
Polar TM3 S 142 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 S 142 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 S 142 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic H8 G 320 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 G 320 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 T 75 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 T 75 2x37 s8s9 T 137 N.s8s9.07
Polar TM1 R 71 1x60 s20c Y 404 C.s20c.14
Hydrophobic TM6 L 258 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 150 34x54 S8 L 130 N.S8.03
Ionic ICL2 R 153 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 153 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 153 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 153 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 153 34x57 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 R 153 34x57 s17s18 R 286 C.s17s18.11
Hydrophobic C-term C 348 - S1 S 13 N.S1.05
Van-der-waals C-term C 348 - S1 S 13 N.S1.05
Ionic H8 K 326 8x53 s5s6 E 67 N.s5s6.03
Polar H8 K 326 8x53 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 326 8x53 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 V 143 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 143 3x54 s5s6 L 74 N.s5s6.10
Polar TM2 T 75 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 T 75 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 T 75 2x37 s5s6 E 67 N.s5s6.03
Polar H8 K 326 8x53 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 A 73 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 A 73 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 A 149 34x53 s5s6 R 66 N.s5s6.02
Polar ICL2 L 150 34x54 s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 L 150 34x54 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 L 150 34x54 s17s18 R 286 C.s17s18.11
Hydrophobic TM2 T 78 2x40 s5s6 E 67 N.s5s6.03
Hydrophobic TM7 Y 316 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 316 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 T 75 2x37 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 T 75 2x37 s8s9 E 135 N.s8s9.05
Polar TM5 E 246 5x68 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 E 246 5x68 s15s16 S 246 C.s15s16.04
Van-der-waals TM5 E 246 5x68 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 L 243 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 243 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 V 143 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 146 34x50 S16 A 248 C.S16.01
Polar TM6 P 254 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 P 254 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 P 254 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic H8 Q 329 8x56 s20c Y 404 C.s20c.14
Van-der-waals H8 Q 329 8x56 s20c Y 404 C.s20c.14
Polar C-term C 348 - s1s2 S 14 N.s1s2.01
Hydrophobic TM4 T 154 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 T 154 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 L 150 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 150 34x54 S16 Y 250 C.S16.03
Polar TM5 K 242 5x64 s15s16 S 246 C.s15s16.04
Polar ICL3 W 248 - s15s16 F 245 C.s15s16.03
Aromatic ICL3 W 248 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 W 248 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 W 248 - s15s16 F 245 C.s15s16.03
Polar H8 R 321 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 R 321 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 R 321 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 P 254 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 P 254 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 V 147 34x51 S16 Q 249 C.S16.02
Hydrophobic ICL2 L 150 34x54 s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 L 150 34x54 s17s18 G 287 C.s17s18.12
Hydrophobic C-term F 344 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term F 344 - s9s10 R 162 N.s9s10.13
Hydrophobic ICL2 V 147 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 L 257 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 L 257 6x36 s5s6 V 71 N.s5s6.07
Polar TM3 S 142 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 S 142 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 S 142 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 R 139 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 139 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 V 143 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 143 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 E 246 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 E 246 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM4 T 154 4x38 s17s18 R 286 C.s17s18.11
Hydrophobic H8 G 320 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 L 257 6x36 s5s6 L 72 N.s5s6.08
Ionic H8 E 325 8x52 s9s10 K 161 N.s9s10.12
Polar H8 E 325 8x52 s9s10 K 161 N.s9s10.12
Van-der-waals H8 E 325 8x52 s9s10 K 161 N.s9s10.12
Aromatic H8 K 326 8x53 s20c Y 404 C.s20c.14
Hydrophobic H8 K 326 8x53 s20c Y 404 C.s20c.14
Hydrophobic ICL3 W 248 - s5s6 S 75 N.s5s6.11