Golf - GPR32 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPR32 77.2
Gαolf 88.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
01
iPTM Score: 0.6
01
PAE mean: 15.9
031


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:
Y02G.S6R17Y23E24L25G.H5GproteinR8x48D8x49S2x39R3x50W-V3x54GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.S6G.H5GPCR segments:TM2TM3ICL3H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x503x533x5434x5034x5134x5434x5534x575x615x645x655x686x306x338x478x488x498x50G.H5.26G.H5.25G.H5.24G.H5.23G.H5.21G.H5.20G.H5.17G.H5.16G.H5.14G.H5.13G.H5.12G.S6.02G.h4s6.20G.h4s6.03G.S3.01G.s2s3.02G.s2s3.01Res. Pos.GPR32 (AFM_GPR32_HUMAN_GNAL_HUMAN)- (AFM_GPR32_HUMAN_GNAL_HUMAN)--------------------SRSVPVLNRIKLEAPGRDFSPVLNRRSVIKLEAPGRDFWYLDQRLRDVKLIYYKET

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.