S-arrestin - GPR33 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR33 84.3
S-arrestin 81.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 18.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL1 K 59 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 K 59 - s8s9 Q 141 N.s8s9.05
Hydrophobic TM6 P 243 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 P 243 6x33 s5s6 I 79 N.s5s6.08
Ionic ICL3 K 239 - S6 D 86 N.S6.04
Polar ICL3 K 239 - S6 D 86 N.S6.04
Hydrophobic ICL3 K 239 - S6 D 86 N.S6.04
Van-der-waals ICL3 K 239 - S6 D 86 N.S6.04
Polar TM2 N 63 2x39 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 N 63 2x39 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 N 63 2x39 s5s6 D 75 N.s5s6.04
Polar H8 E 304 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 E 304 8x48 s5s6 D 77 N.s5s6.06
Polar ICL2 Q 137 34x54 S16 Y 259 C.S16.03
Hydrophobic ICL2 Q 137 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 Q 137 34x54 S16 Y 259 C.S16.03
Hydrophobic TM6 P 243 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 242 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM3 L 129 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 L 129 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM6 V 246 6x36 s5s6 I 79 N.s5s6.08
Ionic ICL3 K 239 - s9s10 E 165 N.s9s10.07
Polar ICL3 K 239 - s9s10 E 165 N.s9s10.07
Polar H8 N 305 8x49 s5s6 E 74 N.s5s6.03
Polar H8 N 305 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 305 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 305 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic TM7 V 302 7x56 s5s6 I 79 N.s5s6.08
Ionic ICL2 R 140 34x57 s5s6 D 75 N.s5s6.04
Polar ICL2 R 140 34x57 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 R 140 34x57 s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 R 140 34x57 s5s6 D 75 N.s5s6.04
Polar ICL2 R 140 34x57 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 R 140 34x57 s5s6 Q 73 N.s5s6.02
Polar ICL2 P 133 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 133 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 133 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL3 L 237 - S6 F 83 N.S6.01
Van-der-waals ICL3 L 237 - S6 F 83 N.S6.01
Polar ICL2 V 134 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 V 134 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 V 134 34x51 S16 D 257 C.S16.01
Polar ICL1 K 59 - s8s9 S 143 N.s8s9.07
Hydrophobic TM3 T 130 3x54 S6 F 83 N.S6.01
Hydrophobic ICL2 P 133 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 133 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic TM5 R 235 5x68 s15s16 S 255 C.s15s16.04
Polar ICL2 Q 137 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Q 137 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Q 137 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 V 134 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 V 134 34x51 S16 Y 259 C.S16.03
Polar TM2 T 61 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 T 61 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 T 61 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic ICL3 L 237 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 L 237 - s15s16 Y 254 C.s15s16.03
Polar H8 G 303 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 G 303 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 G 303 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM7 V 302 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 V 302 7x56 s5s6 V 78 N.s5s6.07
Polar TM5 R 235 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 R 235 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 235 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM2 F 67 2x43 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 F 67 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 P 243 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 P 243 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 R 126 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 126 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 N 63 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 63 2x39 s5s6 V 78 N.s5s6.07
Polar ICL2 Q 137 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 Q 137 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 Q 137 34x54 s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 Q 137 34x54 s5s6 Q 73 N.s5s6.02
Hydrophobic TM5 V 232 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 V 232 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic H8 G 303 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 L 129 3x53 s5s6 Q 73 N.s5s6.02
Van-der-waals TM3 L 129 3x53 s5s6 Q 73 N.s5s6.02
Hydrophobic TM7 V 302 7x56 s5s6 G 80 N.s5s6.09
Van-der-waals TM7 V 302 7x56 s5s6 G 80 N.s5s6.09
Polar TM3 R 126 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 126 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 126 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 L 129 3x53 s5s6 D 75 N.s5s6.04
Van-der-waals ICL2 P 133 34x50 S16 D 257 C.S16.01
Ionic H8 K 311 8x55 s20c E 405 C.s20c.24
Polar H8 K 311 8x55 s20c E 405 C.s20c.24
Van-der-waals H8 K 311 8x55 s20c E 405 C.s20c.24