Beta-arrestin-2 - GPR34 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR34 70.6
Beta-arrestin-2 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 Y 261 6x31 S6 F 76 N.S6.01
Van-der-waals TM6 Y 261 6x31 S6 F 76 N.S6.01
Polar TM7 M 330 7x56 s5s6 G 73 N.s5s6.09
Van-der-waals TM7 M 330 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic ICL3 F 255 - S6 F 76 N.S6.01
Van-der-waals TM6 S 268 6x38 s5s6 L 72 N.s5s6.08
Polar TM6 T 264 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 264 6x34 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 264 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic C-term P 350 - s9s10 R 162 N.s9s10.13
Hydrophobic ICL2 I 160 - S15 I 242 C.S15.14
Polar ICL3 N 257 - S6 R 77 N.S6.02
Hydrophobic ICL3 N 257 - S6 R 77 N.S6.02
Van-der-waals ICL3 N 257 - S6 R 77 N.S6.02
Hydrophobic TM3 I 156 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 156 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 F 255 - S6 K 78 N.S6.03
Van-der-waals ICL3 F 255 - S6 K 78 N.S6.03
Hydrophobic TM3 R 152 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 152 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 N 257 - S6 F 76 N.S6.01
Polar TM6 T 264 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 T 264 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 T 264 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 F 255 - s15s16 L 244 C.s15s16.02
Van-der-waals ICL3 F 255 - s15s16 L 244 C.s15s16.02
Hydrophobic TM2 N 87 2x37 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 N 87 2x37 s5s6 V 71 N.s5s6.07
Polar TM7 M 330 7x56 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 M 330 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 156 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals ICL1 K 85 - s5s6 E 67 N.s5s6.03
Polar TM2 N 87 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 N 87 2x37 s5s6 E 67 N.s5s6.03
Polar TM3 R 158 3x56 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 R 158 3x56 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 L 245 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 245 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 Q 161 - S16 A 248 C.S16.01
Polar H8 S 332 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 S 332 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 P 256 - S6 D 79 N.S6.04
Hydrophobic TM6 Y 261 6x31 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 Y 261 6x31 s15s16 F 245 C.s15s16.03
Polar TM3 S 159 3x57 s5s6 R 66 N.s5s6.02
Polar ICL2 I 160 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 I 160 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 I 160 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 F 255 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 F 255 - s15s16 F 245 C.s15s16.03
Polar TM3 K 155 3x53 s5s6 R 66 N.s5s6.02
Polar TM3 R 152 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 152 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 I 89 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 I 89 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 I 160 - S16 A 248 C.S16.01
Van-der-waals ICL2 I 160 - S16 A 248 C.S16.01
Ionic TM3 K 155 3x53 s5s6 D 68 N.s5s6.04
Polar TM3 K 155 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 K 155 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 K 155 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 I 160 - S5 Y 64 N.S5.12
Van-der-waals ICL2 I 160 - S5 Y 64 N.S5.12
Polar ICL3 R 252 - s15s16 F 245 C.s15s16.03
Aromatic ICL3 R 252 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 R 252 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 R 252 - s15s16 F 245 C.s15s16.03
Hydrophobic H8 S 331 8x47 s5s6 V 71 N.s5s6.07
Polar TM1 H 83 1x61 s20c Y 404 C.s20c.14
Aromatic TM1 H 83 1x61 s20c Y 404 C.s20c.14
Hydrophobic TM1 H 83 1x61 s20c Y 404 C.s20c.14
Van-der-waals TM1 H 83 1x61 s20c Y 404 C.s20c.14
Hydrophobic TM7 M 330 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 M 330 7x56 s5s6 V 71 N.s5s6.07
Polar ICL2 R 163 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 163 - s8s9 T 137 N.s8s9.07
Polar ICL2 Q 162 - s8s9 T 137 N.s8s9.07
Polar ICL2 I 160 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 I 160 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 I 160 - s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 A 165 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 A 165 - s8s9 T 137 N.s8s9.07
Hydrophobic H8 S 332 8x48 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 K 260 6x30 s5s6 L 74 N.s5s6.10
Ionic ICL1 R 84 - s20c D 405 C.s20c.15
Polar ICL1 R 84 - s20c D 405 C.s20c.15
Van-der-waals ICL1 R 84 - s20c D 405 C.s20c.15
Hydrophobic ICL2 I 160 - S16 Y 250 C.S16.03
Van-der-waals ICL2 I 160 - S16 Y 250 C.S16.03
Hydrophobic TM6 Y 261 6x31 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 Y 261 6x31 s5s6 L 74 N.s5s6.10