Arrestin-C - GPR34 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR34 69.7
Arrestin-C 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 S 332 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 F 343 8x59 s20c S 388 C.s20c.22
Van-der-waals H8 F 343 8x59 s20c S 388 C.s20c.22
Polar H8 L 341 8x57 s20c E 386 C.s20c.20
Van-der-waals H8 L 341 8x57 s20c E 386 C.s20c.20
Polar TM6 T 264 6x34 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 264 6x34 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 264 6x34 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 I 160 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 I 160 - s15s16 S 242 C.s15s16.04
Polar H8 K 336 8x52 s20c G 387 C.s20c.21
Hydrophobic H8 K 336 8x52 s20c G 387 C.s20c.21
Van-der-waals H8 K 336 8x52 s20c G 387 C.s20c.21
Polar TM3 R 152 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 152 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 I 160 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 I 160 - s8s9 A 133 N.s8s9.07
Ionic H8 R 344 8x60 s20c E 386 C.s20c.20
Polar H8 R 344 8x60 s20c E 386 C.s20c.20
Polar H8 Q 347 8x63 s9s10 R 158 N.s9s10.13
Hydrophobic H8 Q 347 8x63 s9s10 R 158 N.s9s10.13
Van-der-waals H8 Q 347 8x63 s9s10 R 158 N.s9s10.13
Hydrophobic TM6 T 264 6x34 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 T 264 6x34 s5s6 L 69 N.s5s6.10
Ionic TM3 K 155 3x53 s5s6 D 63 N.s5s6.04
Polar TM3 K 155 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 K 155 3x53 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 K 155 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 Y 261 6x31 s5s6 L 69 N.s5s6.10
Polar TM3 K 155 3x53 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 K 155 3x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 Q 161 - s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 I 160 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 I 160 - s5s6 R 61 N.s5s6.02
Hydrophobic TM3 I 156 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 I 156 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 156 3x54 s5s6 I 67 N.s5s6.08
Polar ICL3 N 257 - S6 D 74 N.S6.04
Aromatic TM6 Y 261 6x31 S6 F 71 N.S6.01
Hydrophobic TM6 Y 261 6x31 S6 F 71 N.S6.01
Van-der-waals TM6 Y 261 6x31 S6 F 71 N.S6.01
Hydrophobic TM7 M 330 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 M 330 7x56 s5s6 V 66 N.s5s6.07
Polar H8 N 333 8x49 s20c E 383 C.s20c.17
Polar H8 Q 340 8x56 s20c D 385 C.s20c.19
Hydrophobic H8 Q 340 8x56 s20c D 385 C.s20c.19
Van-der-waals H8 Q 340 8x56 s20c D 385 C.s20c.19
Polar H8 Q 340 8x56 s20c A 382 C.s20c.15
Van-der-waals H8 Q 340 8x56 s20c A 382 C.s20c.15
Hydrophobic TM3 R 152 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 152 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals ICL2 I 160 - S5 Y 59 N.S5.12
Polar TM3 R 158 3x56 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 R 158 3x56 s5s6 R 61 N.s5s6.02
Hydrophobic ICL1 R 84 - s20c V 380 C.s20c.13
Van-der-waals ICL1 R 84 - s20c V 380 C.s20c.13
Ionic ICL1 R 84 - s20c E 383 C.s20c.17
Polar ICL1 R 84 - s20c E 383 C.s20c.17
Hydrophobic ICL1 R 84 - s20c E 383 C.s20c.17
Van-der-waals ICL1 R 84 - s20c E 383 C.s20c.17
Hydrophobic ICL3 P 256 - S6 D 74 N.S6.04
Polar ICL3 N 257 - S6 R 72 N.S6.02
Hydrophobic ICL3 N 257 - S6 R 72 N.S6.02
Van-der-waals ICL3 N 257 - S6 R 72 N.S6.02
Hydrophobic TM6 Y 261 6x31 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 Y 261 6x31 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 S 268 6x38 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 S 268 6x38 s5s6 I 67 N.s5s6.08
Ionic ICL2 R 163 - s8s9 E 131 N.s8s9.05
Polar ICL2 R 163 - s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 R 163 - s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 R 163 - s8s9 E 131 N.s8s9.05
Aromatic ICL3 F 255 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 F 255 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 F 255 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 P 256 - S6 K 73 N.S6.03
Aromatic ICL3 F 255 - S6 K 73 N.S6.03
Hydrophobic ICL3 F 255 - S6 K 73 N.S6.03
Van-der-waals ICL3 F 255 - S6 K 73 N.S6.03
Hydrophobic TM2 N 87 2x37 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 N 87 2x37 s5s6 V 66 N.s5s6.07
Polar TM7 M 330 7x56 s5s6 G 68 N.s5s6.09
Van-der-waals TM7 M 330 7x56 s5s6 G 68 N.s5s6.09
Hydrophobic H8 I 337 8x53 s20c E 386 C.s20c.20
Van-der-waals H8 I 337 8x53 s20c E 386 C.s20c.20
Hydrophobic ICL2 I 160 - s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 I 160 - s8s9 G 134 N.s8s9.08
Hydrophobic H8 C 339 8x55 s20c G 387 C.s20c.21
Hydrophobic ICL2 R 163 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 R 163 - s8s9 A 133 N.s8s9.07
Hydrophobic TM2 I 89 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 I 89 2x39 s5s6 V 66 N.s5s6.07
Ionic ICL2 R 163 - s8s9 D 132 N.s8s9.06
Polar ICL3 R 252 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 R 252 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 R 252 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 I 160 - S16 D 244 C.S16.01
Van-der-waals ICL2 I 160 - S16 D 244 C.S16.01
Polar H8 Q 340 8x56 s20c E 386 C.s20c.20
Hydrophobic H8 Q 340 8x56 s20c E 386 C.s20c.20
Van-der-waals H8 Q 340 8x56 s20c E 386 C.s20c.20
Hydrophobic H8 K 336 8x52 s20c E 386 C.s20c.20
Van-der-waals H8 K 336 8x52 s20c E 386 C.s20c.20
Polar TM7 M 330 7x56 s5s6 I 67 N.s5s6.08
Hydrophobic TM7 M 330 7x56 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 M 330 7x56 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 K 260 6x30 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 K 260 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic H8 S 332 8x48 s5s6 G 68 N.s5s6.09
Hydrophobic H8 C 339 8x55 s20c E 386 C.s20c.20
Van-der-waals H8 C 339 8x55 s20c E 386 C.s20c.20
Hydrophobic TM5 L 245 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 F 255 - s15s16 L 240 C.s15s16.02