Beta-arrestin-1 - GPR35 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR35 77.6
Beta-arrestin-1 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 18.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 M 59 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 M 59 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 122 34x51 S9 C 140 N.S9.01
Hydrophobic ICL2 L 122 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 122 34x51 S16 A 247 C.S16.01
Hydrophobic ICL3 T 204 - S6 K 77 N.S6.03
Van-der-waals ICL3 T 204 - S6 K 77 N.S6.03
Hydrophobic TM6 T 212 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic H8 E 282 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 E 282 8x49 s5s6 D 69 N.s5s6.06
Polar TM6 Q 208 6x26 S6 R 76 N.S6.02
Hydrophobic TM6 Q 208 6x26 S6 R 76 N.S6.02
Van-der-waals TM6 Q 208 6x26 S6 R 76 N.S6.02
Polar ICL2 P 121 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 121 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 121 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 121 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 121 34x50 s15s16 N 245 C.s15s16.04
Polar TM6 Q 208 6x26 s5s6 T 74 N.s5s6.11
Polar TM3 R 119 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 R 119 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 V 194 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 215 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 215 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 198 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 198 5x65 s5s6 L 73 N.s5s6.10
Polar ICL3 T 204 - S6 D 78 N.S6.04
Hydrophobic ICL3 T 204 - S6 D 78 N.S6.04
Van-der-waals ICL3 T 204 - S6 D 78 N.S6.04
Hydrophobic TM6 A 215 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 215 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 198 5x65 S6 F 75 N.S6.01
Van-der-waals TM5 L 198 5x65 S6 F 75 N.S6.01
Hydrophobic H8 E 282 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 E 282 8x49 s5s6 D 67 N.s5s6.04
Polar ICL1 Q 50 12x49 s20c K 403 C.s20c.13
Van-der-waals ICL1 Q 50 12x49 s20c K 403 C.s20c.13
Aromatic TM5 R 201 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 R 201 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 R 201 5x68 S6 F 75 N.S6.01
Ionic TM4 R 131 4x40 s8s9 E 134 N.s8s9.05
Polar TM4 R 131 4x40 s8s9 E 134 N.s8s9.05
Polar ICL2 R 125 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 R 125 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic TM6 A 211 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 A 117 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 117 3x53 s5s6 L 68 N.s5s6.05
Polar TM2 T 53 2x37 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 T 53 2x37 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 T 53 2x37 s5s6 D 69 N.s5s6.06
Polar ICL2 L 122 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 122 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 122 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 R 125 34x54 s8s9 A 139 N.s8s9.10
Van-der-waals ICL2 R 125 34x54 s8s9 A 139 N.s8s9.10
Van-der-waals ICL2 L 122 34x51 s15s16 N 245 C.s15s16.04
Polar ICL3 T 204 - S6 R 76 N.S6.02
Polar ICL1 Q 51 12x50 s20c E 404 C.s20c.14
Van-der-waals ICL1 Q 51 12x50 s20c E 404 C.s20c.14
Ionic TM2 E 54 2x38 s5s6 R 65 N.s5s6.02
Polar TM2 E 54 2x38 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 E 54 2x38 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 L 198 5x65 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 T 55 2x39 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 I 110 3x46 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 122 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 122 34x51 S15 I 241 C.S15.14
Hydrophobic ICL2 R 125 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 125 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM2 T 53 2x37 s5s6 D 67 N.s5s6.04
Polar TM3 R 114 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 114 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 114 3x50 s5s6 V 70 N.s5s6.07
Polar ICL2 R 125 34x54 S8 L 129 N.S8.03
Hydrophobic TM6 V 219 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 219 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 V 118 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 M 218 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 R 125 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 R 125 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals TM3 H 120 3x56 s15s16 N 245 C.s15s16.04
Polar ICL2 L 122 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 122 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 122 34x51 S16 Y 249 C.S16.03
Polar ICL2 R 125 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 R 125 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 R 125 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic TM6 M 218 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 M 218 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 T 55 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 T 55 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 114 3x50 s5s6 L 71 N.s5s6.08
Polar ICL2 R 128 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 R 201 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 201 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 L 122 34x51 S8 L 129 N.S8.03