ArrestinDb

Beta-arrestin-2 - GPR35 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
GPR35	77.8
Beta-arrestin-2	79.0

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 18.2

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	TM5	R	201	5x68	S6	F	76	N.S6.01
Hydrophobic	TM5	L	198	5x65	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL2	L	122	34x51	s8s9	A	140	N.s8s9.10
Hydrophobic	TM6	V	219	6x37	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	L	122	34x51	S16	Y	250	C.S16.03
Hydrophobic	TM5	L	198	5x65	s5s6	L	72	N.s5s6.08
Hydrophobic	TM3	V	118	3x54	s5s6	L	69	N.s5s6.05
Hydrophobic	ICL3	T	204	-	S6	K	78	N.S6.03
Hydrophobic	ICL2	P	121	34x50	S5	Y	64	N.S5.12
Hydrophobic	ICL2	R	125	34x54	s8s9	P	132	N.s8s9.02
Hydrophobic	H8	E	282	8x49	s5s6	D	70	N.s5s6.06
Hydrophobic	TM5	R	201	5x68	s15s16	F	245	C.s15s16.03
Hydrophobic	ICL2	L	122	34x51	S16	A	248	C.S16.01
Hydrophobic	TM6	Q	208	6x26	S6	R	77	N.S6.02
Hydrophobic	TM6	M	218	6x36	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	P	121	34x50	s15s16	S	246	C.s15s16.04
Hydrophobic	ICL2	R	125	34x54	s5s6	R	66	N.s5s6.02
Hydrophobic	ICL2	R	125	34x54	s8s9	K	139	N.s8s9.09
Hydrophobic	TM6	A	215	6x33	s5s6	L	74	N.s5s6.10
Hydrophobic	TM2	T	55	2x39	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL1	Q	51	12x50	s20c	Y	404	C.s20c.14
Hydrophobic	TM6	T	212	6x30	s5s6	L	74	N.s5s6.10
Hydrophobic	TM6	A	211	6x29	s5s6	L	74	N.s5s6.10
Hydrophobic	TM3	R	114	3x50	s5s6	L	72	N.s5s6.08
Hydrophobic	TM6	M	218	6x36	s5s6	V	71	N.s5s6.07
Hydrophobic	TM5	R	201	5x68	S6	F	76	N.S6.01
Hydrophobic	TM6	A	215	6x33	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	L	122	34x51	S8	L	130	N.S8.03
Hydrophobic	ICL2	L	122	34x51	S5	Y	64	N.S5.12
Hydrophobic	ICL2	R	125	34x54	s8s9	G	138	N.s8s9.08
Hydrophobic	ICL2	L	122	34x51	S9	C	141	N.S9.01
Hydrophobic	TM5	V	194	5x61	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	R	125	34x54	s8s9	A	140	N.s8s9.10
Hydrophobic	TM5	L	198	5x65	S6	F	76	N.S6.01
Hydrophobic	TM3	R	114	3x50	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL1	Q	50	12x49	s20c	Y	404	C.s20c.14
Hydrophobic	TM2	M	59	2x43	s5s6	V	71	N.s5s6.07
Hydrophobic	TM3	I	110	3x46	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL2	L	122	34x51	S15	I	242	C.S15.14
Hydrophobic	ICL2	R	125	34x54	s8s9	D	136	N.s8s9.06
Hydrophobic	TM2	T	53	2x37	s5s6	D	68	N.s5s6.04
Hydrophobic	TM3	A	117	3x53	s5s6	L	69	N.s5s6.05
Ionic	TM2	E	54	2x38	s5s6	R	66	N.s5s6.02
Ionic	TM4	R	131	4x40	s8s9	E	135	N.s8s9.05
Polar	ICL3	T	204	-	S6	R	77	N.S6.02
Polar	ICL1	Q	51	12x50	s8s9	T	137	N.s8s9.07
Polar	ICL2	P	121	34x50	S5	Y	64	N.S5.12
Polar	TM6	Q	208	6x26	S6	R	77	N.S6.02
Polar	ICL2	R	125	34x54	s8s9	K	139	N.s8s9.09
Polar	ICL3	T	204	-	S6	D	79	N.S6.04
Polar	TM2	T	55	2x39	s5s6	V	71	N.s5s6.07
Polar	ICL1	Q	51	12x50	s20c	Y	404	C.s20c.14
Polar	TM2	E	54	2x38	s5s6	R	66	N.s5s6.02
Polar	ICL2	R	128	34x57	s5s6	R	66	N.s5s6.02
Polar	ICL2	R	125	34x54	s8s9	G	138	N.s8s9.08
Polar	TM3	R	114	3x50	s5s6	V	71	N.s5s6.07
Polar	ICL1	Q	50	12x49	s20c	Y	404	C.s20c.14
Polar	TM4	R	131	4x40	s8s9	E	135	N.s8s9.05
Polar	ICL2	R	128	34x57	s5s6	D	68	N.s5s6.04
Van-der-waals	TM5	L	198	5x65	s5s6	L	74	N.s5s6.10
Van-der-waals	ICL3	T	204	-	S6	R	77	N.S6.02
Van-der-waals	TM6	V	219	6x37	s5s6	L	72	N.s5s6.08
Van-der-waals	ICL2	L	122	34x51	S16	Y	250	C.S16.03
Van-der-waals	ICL3	T	204	-	S6	K	78	N.S6.03
Van-der-waals	ICL2	P	121	34x50	S5	Y	64	N.S5.12
Van-der-waals	ICL2	R	125	34x54	s8s9	P	132	N.s8s9.02
Van-der-waals	H8	E	282	8x49	s5s6	D	70	N.s5s6.06
Van-der-waals	TM5	R	201	5x68	s15s16	F	245	C.s15s16.03
Van-der-waals	TM6	Q	208	6x26	S6	R	77	N.S6.02
Van-der-waals	ICL2	R	125	34x54	s5s6	R	66	N.s5s6.02
Van-der-waals	ICL2	R	125	34x54	s8s9	K	139	N.s8s9.09
Van-der-waals	TM6	A	215	6x33	s5s6	L	74	N.s5s6.10
Van-der-waals	TM2	T	55	2x39	s5s6	V	71	N.s5s6.07
Van-der-waals	ICL1	Q	51	12x50	s20c	Y	404	C.s20c.14
Van-der-waals	TM2	E	54	2x38	s5s6	R	66	N.s5s6.02
Van-der-waals	TM6	M	218	6x36	s5s6	V	71	N.s5s6.07
Van-der-waals	TM5	R	201	5x68	S6	F	76	N.S6.01
Van-der-waals	ICL2	L	122	34x51	S8	L	130	N.S8.03
Van-der-waals	ICL2	L	122	34x51	S5	Y	64	N.S5.12
Van-der-waals	ICL2	R	125	34x54	s8s9	G	138	N.s8s9.08
Van-der-waals	ICL2	R	125	34x54	s8s9	A	140	N.s8s9.10
Van-der-waals	TM5	L	198	5x65	S6	F	76	N.S6.01
Van-der-waals	TM3	R	114	3x50	s5s6	V	71	N.s5s6.07
Van-der-waals	ICL1	Q	50	12x49	s20c	Y	404	C.s20c.14
Van-der-waals	ICL2	L	122	34x51	S15	I	242	C.S15.14
Van-der-waals	ICL2	R	125	34x54	s8s9	D	136	N.s8s9.06
Van-der-waals	TM4	R	131	4x40	s8s9	E	135	N.s8s9.05
Van-der-waals	TM3	A	117	3x53	s5s6	L	69	N.s5s6.05

Showing 1 to 88 of 88 entries

Join us

Cite us

Main reference

Beta-arrestin-2 - GPR35 complex model Download Full