Gi1 - GPR37 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-05-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR37 51.3
Gαi1 89.4
Gβ1 91.1
Gγ2 74.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 27.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 Y 290 12x48 G.HN D 20 G.HN.44
Hydrophobic ICL1 Y 290 12x48 G.HN D 20 G.HN.44
Van-der-waals ICL1 Y 290 12x48 G.HN D 20 G.HN.44
Polar ICL2 Q 367 34x50 G.h3s5 D 261 G.h3s5.02
Hydrophobic ICL2 Q 367 34x50 G.h3s5 D 261 G.h3s5.02
Van-der-waals ICL2 Q 367 34x50 G.h3s5 D 261 G.h3s5.02
Hydrophobic ICL1 Y 290 12x48 G.HN R 24 G.HN.48
Van-der-waals ICL1 Y 290 12x48 G.HN R 24 G.HN.48
Van-der-waals TM3 N 365 3x56 G.H5 D 350 G.H5.22
Hydrophobic C-term L 591 - G.H3 N 256 G.H3.15
Hydrophobic C-term F 596 - G.H2 R 205 G.H2.01
Van-der-waals C-term F 596 - G.H2 R 205 G.H2.01
Polar ICL2 I 373 34x56 G.HN R 24 G.HN.48
Hydrophobic ICL2 I 373 34x56 G.HN R 24 G.HN.48
Van-der-waals ICL2 I 373 34x56 G.HN R 24 G.HN.48
Hydrophobic C-term L 593 - G.H3 S 252 G.H3.11
Van-der-waals C-term L 593 - G.H3 S 252 G.H3.11
Polar TM4 N 375 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 N 375 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 N 375 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 N 375 4x38 G.HN R 24 G.HN.48
Ionic C-term E 590 - G.H3 K 257 G.H3.16
Polar C-term E 590 - G.H3 K 257 G.H3.16
Hydrophobic C-term E 590 - G.H3 K 257 G.H3.16
Van-der-waals C-term E 590 - G.H3 K 257 G.H3.16
Polar C-term E 592 - G.H3 S 252 G.H3.11
Van-der-waals C-term E 592 - G.H3 S 252 G.H3.11
Hydrophobic ICL2 I 373 34x56 G.HN E 28 G.HN.52
Van-der-waals ICL2 I 373 34x56 G.HN E 28 G.HN.52
Polar ICL1 Y 290 12x48 G.HN R 21 G.HN.45
Hydrophobic ICL2 E 374 34x57 G.HN E 28 G.HN.52
Hydrophobic C-term L 593 - G.H3 L 249 G.H3.08
Polar TM3 T 364 3x55 G.H5 D 350 G.H5.22
Van-der-waals TM3 T 364 3x55 G.H5 D 350 G.H5.22
Polar ICL1 Y 291 12x49 G.HN D 20 G.HN.44
Van-der-waals ICL1 Y 291 12x49 G.HN D 20 G.HN.44
Polar ICL2 E 374 34x57 G.HN R 24 G.HN.48
Hydrophobic ICL2 E 374 34x57 G.HN R 24 G.HN.48
Van-der-waals ICL2 E 374 34x57 G.HN R 24 G.HN.48
Hydrophobic ICL3 T 477 - G.H3 K 257 G.H3.16
Van-der-waals ICL3 T 477 - G.H3 K 257 G.H3.16
Hydrophobic C-term L 593 - G.H3 I 253 G.H3.12