Beta-arrestin-1 - GPR39 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR39 71.1
Beta-arrestin-1 78.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 Q 350 8x49 s5s6 D 69 N.s5s6.06
Ionic TM6 E 272 6x24 s9s10 K 157 N.s9s10.09
Polar TM6 E 272 6x24 s9s10 K 157 N.s9s10.09
Hydrophobic TM6 E 272 6x24 s9s10 K 157 N.s9s10.09
Van-der-waals TM6 E 272 6x24 s9s10 K 157 N.s9s10.09
Hydrophobic ICL3 L 266 - S6 A 82 N.S6.08
Polar TM3 R 133 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 133 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 133 3x50 s5s6 V 70 N.s5s6.07
Ionic C-term K 372 - s5s6 E 66 N.s5s6.03
Polar C-term K 372 - s5s6 E 66 N.s5s6.03
Hydrophobic C-term K 372 - s5s6 E 66 N.s5s6.03
Van-der-waals C-term K 372 - s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 F 141 34x51 s15s16 C 242 C.s15s16.01
Van-der-waals ICL2 F 141 34x51 s15s16 C 242 C.s15s16.01
Polar TM6 T 281 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 281 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 281 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 281 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 T 281 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL1 G 62 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 G 62 - s5s6 D 67 N.s5s6.04
Hydrophobic TM3 H 139 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals ICL1 Q 65 - s5s6 L 68 N.s5s6.05
Ionic C-term K 372 - s20c E 405 C.s20c.15
Polar C-term K 372 - s20c E 405 C.s20c.15
Hydrophobic C-term K 372 - s20c E 405 C.s20c.15
Van-der-waals C-term K 372 - s20c E 405 C.s20c.15
Ionic C-term R 373 - s20c D 401 C.s20c.11
Polar C-term R 373 - s20c D 401 C.s20c.11
Hydrophobic C-term R 373 - s20c D 401 C.s20c.11
Van-der-waals C-term R 373 - s20c D 401 C.s20c.11
Hydrophobic ICL1 L 64 - s5s6 D 67 N.s5s6.04
Hydrophobic TM6 F 284 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 F 284 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 141 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 F 141 34x51 S16 A 247 C.S16.01
Hydrophobic C-term N 369 - s20c K 403 C.s20c.13
Van-der-waals C-term N 369 - s20c K 403 C.s20c.13
Hydrophobic ICL2 F 141 34x51 S5 F 61 N.S5.10
Polar ICL2 P 140 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 P 140 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 140 34x50 s15s16 N 245 C.s15s16.04
Polar ICL2 P 140 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 140 34x50 S5 Y 63 N.S5.12
Hydrophobic TM4 P 149 4x39 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 P 149 4x39 s8s9 T 136 N.s8s9.07
Polar ICL1 Q 65 - s8s9 K 138 N.s8s9.09
Hydrophobic ICL1 Q 65 - s8s9 K 138 N.s8s9.09
Van-der-waals ICL1 Q 65 - s8s9 K 138 N.s8s9.09
Hydrophobic TM3 R 133 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 133 3x50 s5s6 L 71 N.s5s6.08
Aromatic ICL2 F 141 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 F 141 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 F 141 34x51 S5 Y 63 N.S5.12
Hydrophobic TM4 G 148 4x38 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 L 249 5x68 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 F 141 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 F 141 34x51 s15s16 L 243 C.s15s16.02
Polar ICL2 K 144 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 K 144 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 K 144 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 L 64 - s5s6 D 69 N.s5s6.06
Hydrophobic TM5 L 249 5x68 S6 F 75 N.S6.01
Hydrophobic ICL2 F 141 34x51 S9 C 140 N.S9.01
Hydrophobic TM2 V 68 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 V 68 2x39 s5s6 V 70 N.s5s6.07
Polar ICL2 S 147 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 L 266 - S6 N 83 N.S6.09
Polar ICL1 Q 65 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 Q 65 - s8s9 T 136 N.s8s9.07
Polar ICL2 K 144 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 K 144 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 K 144 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL1 Q 65 - s5s6 D 67 N.s5s6.04
Ionic ICL3 R 267 - s9s10 E 155 N.s9s10.07
Polar ICL3 R 267 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 R 267 - s9s10 E 155 N.s9s10.07
Hydrophobic TM7 S 347 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 S 347 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 M 72 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 137 3x54 s5s6 L 71 N.s5s6.08
Polar TM7 S 347 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic C-term R 373 - s20c K 403 C.s20c.13
Van-der-waals C-term R 373 - s20c K 403 C.s20c.13
Ionic ICL2 K 144 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM3 I 137 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 137 3x54 s5s6 L 73 N.s5s6.10
Polar ICL2 F 141 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 F 141 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 F 141 34x51 s15s16 N 245 C.s15s16.04
Polar ICL2 P 140 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 P 140 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 140 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 I 137 3x54 S6 F 75 N.S6.01
Polar C-term H 370 - s20c K 403 C.s20c.13
Aromatic C-term H 370 - s20c K 403 C.s20c.13
Hydrophobic C-term H 370 - s20c K 403 C.s20c.13
Van-der-waals C-term H 370 - s20c K 403 C.s20c.13
Polar H8 S 348 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 348 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 348 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 F 141 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 F 141 34x51 S15 I 241 C.S15.14
Hydrophobic TM2 E 67 2x38 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 Y 63 - s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 F 141 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 F 141 34x51 s15s16 T 246 C.s15s16.05
Polar ICL2 K 144 34x54 S16 Y 249 C.S16.03
Hydrophobic ICL2 K 144 34x54 S16 Y 249 C.S16.03
Van-der-waals ICL2 K 144 34x54 S16 Y 249 C.S16.03
Hydrophobic ICL1 Y 63 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 Y 63 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL3 L 266 - S6 V 81 N.S6.07
Van-der-waals ICL3 L 266 - S6 V 81 N.S6.07
Hydrophobic ICL1 L 64 - s5s6 V 70 N.s5s6.07