ArrestinDb

Beta-arrestin-2 - GPR3 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
GPR3	76.1
Beta-arrestin-2	78.1

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 18.6

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	C-term	R	323	-	s20c	Y	404	C.s20c.14
Aromatic	ICL2	Y	145	34x54	s5s6	R	66	N.s5s6.02
Aromatic	TM5	H	223	5x68	s15s16	F	245	C.s15s16.03
Hydrophobic	ICL2	A	141	34x50	s5s6	G	65	N.s5s6.01
Hydrophobic	TM3	R	134	3x50	s5s6	L	69	N.s5s6.05
Hydrophobic	TM2	M	75	2x39	s5s6	D	68	N.s5s6.04
Hydrophobic	C-term	R	323	-	s20c	D	401	C.s20c.11
Hydrophobic	C-term	S	328	-	s8s9	K	139	N.s8s9.09
Hydrophobic	TM6	G	245	6x33	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL2	T	143	34x52	S16	Y	250	C.S16.03
Hydrophobic	TM6	L	249	6x37	s5s6	L	72	N.s5s6.08
Hydrophobic	TM7	Y	297	7x53	s5s6	V	71	N.s5s6.07
Hydrophobic	TM3	Y	139	3x55	s15s16	S	246	C.s15s16.04
Hydrophobic	C-term	P	327	-	s5s6	E	67	N.s5s6.03
Hydrophobic	TM5	H	223	5x68	s15s16	L	244	C.s15s16.02
Hydrophobic	ICL2	L	142	34x51	S16	A	248	C.S16.01
Hydrophobic	TM5	V	220	5x65	S6	F	76	N.S6.01
Hydrophobic	H8	N	301	8x47	s5s6	V	71	N.s5s6.07
Hydrophobic	TM2	M	75	2x39	s5s6	V	71	N.s5s6.07
Hydrophobic	C-term	P	327	-	s8s9	G	138	N.s8s9.08
Hydrophobic	TM3	R	134	3x50	s5s6	V	71	N.s5s6.07
Hydrophobic	TM5	Q	226	5x71	s17s18	E	314	C.s17s18.39
Hydrophobic	TM5	I	227	5x72	S6	K	78	N.S6.03
Hydrophobic	TM6	V	252	6x40	s5s6	L	72	N.s5s6.08
Hydrophobic	TM6	T	248	6x36	s5s6	L	72	N.s5s6.08
Hydrophobic	C-term	P	321	-	s20c	Y	404	C.s20c.14
Hydrophobic	TM3	R	134	3x50	s5s6	L	72	N.s5s6.08
Hydrophobic	C-term	R	323	-	s20c	Y	404	C.s20c.14
Hydrophobic	TM3	S	137	3x53	s5s6	L	69	N.s5s6.05
Hydrophobic	ICL2	Y	145	34x54	s5s6	R	66	N.s5s6.02
Hydrophobic	C-term	R	323	-	s20c	D	402	C.s20c.12
Hydrophobic	ICL2	Y	145	34x54	s8s9	T	137	N.s8s9.07
Hydrophobic	TM5	R	231	5x76	S6	D	79	N.S6.04
Hydrophobic	TM5	R	231	5x76	S6	L	80	N.S6.05
Hydrophobic	ICL2	Y	145	34x54	s8s9	E	135	N.s8s9.05
Hydrophobic	ICL2	L	142	34x51	S15	I	242	C.S15.14
Hydrophobic	TM5	Q	230	5x75	s17s18	E	314	C.s17s18.39
Hydrophobic	TM3	L	138	3x54	S6	F	76	N.S6.01
Hydrophobic	ICL2	Y	145	34x54	s8s9	D	136	N.s8s9.06
Hydrophobic	ICL2	L	142	34x51	S16	Y	250	C.S16.03
Hydrophobic	C-term	V	330	-	S10	R	166	N.S10.03
Hydrophobic	TM3	L	138	3x54	S5	Y	64	N.S5.12
Hydrophobic	C-term	R	323	-	s20c	D	403	C.s20c.13
Hydrophobic	TM5	Q	230	5x75	s17s18	N	312	C.s17s18.37
Hydrophobic	C-term	P	327	-	s8s9	K	139	N.s8s9.09
Hydrophobic	TM6	H	238	6x26	S6	D	79	N.S6.04
Hydrophobic	ICL2	Y	144	34x53	s5s6	R	66	N.s5s6.02
Hydrophobic	TM5	I	216	5x61	s5s6	L	74	N.s5s6.10
Hydrophobic	TM5	R	231	5x76	S6	F	81	N.S6.06
Hydrophobic	ICL2	L	142	34x51	S5	Y	64	N.S5.12
Hydrophobic	ICL2	Y	145	34x54	s8s9	G	138	N.s8s9.08
Hydrophobic	TM6	H	238	6x26	S6	K	78	N.S6.03
Hydrophobic	ICL2	L	142	34x51	S9	C	141	N.S9.01
Hydrophobic	TM3	L	138	3x54	s5s6	L	69	N.s5s6.05
Hydrophobic	TM6	G	245	6x33	s5s6	G	73	N.s5s6.09
Hydrophobic	TM6	H	238	6x26	S6	R	77	N.S6.02
Hydrophobic	C-term	D	329	-	s9s10	K	161	N.s9s10.12
Hydrophobic	TM5	Y	213	5x58	s5s6	L	72	N.s5s6.08
Hydrophobic	TM5	V	220	5x65	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL2	A	141	34x50	S5	Y	64	N.S5.12
Hydrophobic	ICL3	L	233	-	S6	F	81	N.S6.06
Hydrophobic	ICL2	L	142	34x51	S8	L	130	N.S8.03
Hydrophobic	TM5	H	223	5x68	s15s16	F	245	C.s15s16.03
Hydrophobic	TM6	P	235	6x23	S6	I	82	N.S6.07
Hydrophobic	TM5	Q	230	5x75	s17s18	V	315	C.s17s18.40
Ionic	TM6	H	238	6x26	S6	D	79	N.S6.04
Ionic	C-term	D	329	-	s9s10	K	161	N.s9s10.12
Polar	C-term	R	323	-	s20c	D	401	C.s20c.11
Polar	ICL2	Y	145	34x54	s17s18	R	286	C.s17s18.11
Polar	ICL2	T	143	34x52	S16	Y	250	C.S16.03
Polar	TM3	Y	139	3x55	s15s16	S	246	C.s15s16.04
Polar	C-term	P	327	-	s5s6	E	67	N.s5s6.03
Polar	TM5	H	223	5x68	s15s16	L	244	C.s15s16.02
Polar	C-term	S	328	-	s17s18	K	293	C.s17s18.18
Polar	C-term	P	327	-	S5	R	63	N.S5.11
Polar	TM5	Q	226	5x71	s17s18	E	314	C.s17s18.39
Polar	ICL2	Y	145	34x54	s5s6	R	66	N.s5s6.02
Polar	C-term	R	323	-	s20c	D	402	C.s20c.12
Polar	ICL2	Y	145	34x54	s8s9	T	137	N.s8s9.07
Polar	TM5	R	231	5x76	S6	D	79	N.S6.04
Polar	TM5	R	231	5x76	S6	L	80	N.S6.05
Polar	TM5	Q	230	5x75	s17s18	E	314	C.s17s18.39
Polar	C-term	V	330	-	S10	R	166	N.S10.03
Polar	TM3	L	138	3x54	S5	Y	64	N.S5.12
Polar	C-term	R	323	-	s20c	D	403	C.s20c.13
Polar	TM5	Q	230	5x75	s17s18	N	312	C.s17s18.37
Polar	C-term	P	327	-	s8s9	K	139	N.s8s9.09
Polar	TM6	H	238	6x26	S6	D	79	N.S6.04
Polar	ICL2	Y	144	34x53	s5s6	R	66	N.s5s6.02
Polar	ICL2	Y	145	34x54	s8s9	G	138	N.s8s9.08
Polar	C-term	D	329	-	s9s10	K	161	N.s9s10.12
Polar	TM5	Q	230	5x75	S6	K	78	N.S6.03
Polar	ICL2	A	141	34x50	S5	Y	64	N.S5.12
Polar	TM5	H	223	5x68	s15s16	F	245	C.s15s16.03
Polar	TM5	Q	230	5x75	s17s18	V	315	C.s17s18.40
Van-der-waals	TM2	M	75	2x39	s5s6	D	68	N.s5s6.04
Van-der-waals	C-term	R	323	-	s20c	D	401	C.s20c.11
Van-der-waals	C-term	S	328	-	s8s9	K	139	N.s8s9.09
Van-der-waals	ICL2	Y	145	34x54	s17s18	R	286	C.s17s18.11
Van-der-waals	ICL2	T	143	34x52	S16	Y	250	C.S16.03
Van-der-waals	TM6	L	249	6x37	s5s6	L	72	N.s5s6.08
Van-der-waals	TM7	Y	297	7x53	s5s6	V	71	N.s5s6.07
Van-der-waals	TM3	Y	139	3x55	s15s16	S	246	C.s15s16.04
Van-der-waals	C-term	P	327	-	s5s6	E	67	N.s5s6.03
Van-der-waals	TM5	H	223	5x68	s15s16	L	244	C.s15s16.02
Van-der-waals	C-term	S	328	-	s17s18	K	293	C.s17s18.18
Van-der-waals	TM5	V	220	5x65	S6	F	76	N.S6.01
Van-der-waals	TM2	M	75	2x39	s5s6	V	71	N.s5s6.07
Van-der-waals	TM3	R	134	3x50	s5s6	V	71	N.s5s6.07
Van-der-waals	TM5	Q	226	5x71	s17s18	E	314	C.s17s18.39
Van-der-waals	TM5	I	227	5x72	S6	K	78	N.S6.03
Van-der-waals	TM6	T	248	6x36	s5s6	L	72	N.s5s6.08
Van-der-waals	C-term	P	321	-	s20c	Y	404	C.s20c.14
Van-der-waals	TM3	R	134	3x50	s5s6	L	72	N.s5s6.08
Van-der-waals	C-term	R	323	-	s20c	Y	404	C.s20c.14
Van-der-waals	TM3	S	137	3x53	s5s6	L	69	N.s5s6.05
Van-der-waals	ICL2	Y	145	34x54	s5s6	R	66	N.s5s6.02
Van-der-waals	C-term	R	323	-	s20c	D	402	C.s20c.12
Van-der-waals	ICL2	Y	145	34x54	s8s9	T	137	N.s8s9.07
Van-der-waals	TM5	R	231	5x76	S6	D	79	N.S6.04
Van-der-waals	TM5	R	231	5x76	S6	L	80	N.S6.05
Van-der-waals	ICL2	Y	145	34x54	s8s9	E	135	N.s8s9.05
Van-der-waals	ICL2	L	142	34x51	S15	I	242	C.S15.14
Van-der-waals	TM5	Q	230	5x75	s17s18	E	314	C.s17s18.39
Van-der-waals	TM3	L	138	3x54	S6	F	76	N.S6.01
Van-der-waals	ICL2	Y	145	34x54	s8s9	D	136	N.s8s9.06
Van-der-waals	ICL2	L	142	34x51	S16	Y	250	C.S16.03
Van-der-waals	C-term	V	330	-	S10	R	166	N.S10.03
Van-der-waals	TM3	L	138	3x54	S5	Y	64	N.S5.12
Van-der-waals	C-term	R	323	-	s20c	D	403	C.s20c.13
Van-der-waals	TM5	Q	230	5x75	s17s18	N	312	C.s17s18.37
Van-der-waals	C-term	P	327	-	s8s9	K	139	N.s8s9.09
Van-der-waals	TM6	H	238	6x26	S6	D	79	N.S6.04
Van-der-waals	ICL2	Y	144	34x53	s5s6	R	66	N.s5s6.02
Van-der-waals	TM5	I	216	5x61	s5s6	L	74	N.s5s6.10
Van-der-waals	TM5	R	231	5x76	S6	F	81	N.S6.06
Van-der-waals	ICL2	Y	145	34x54	s8s9	G	138	N.s8s9.08
Van-der-waals	ICL2	L	142	34x51	S9	C	141	N.S9.01
Van-der-waals	C-term	D	329	-	s9s10	K	161	N.s9s10.12
Van-der-waals	TM5	Y	213	5x58	s5s6	L	72	N.s5s6.08
Van-der-waals	TM5	R	231	5x76	S6	I	82	N.S6.07
Van-der-waals	ICL2	A	141	34x50	S5	Y	64	N.S5.12
Van-der-waals	ICL2	L	142	34x51	S8	L	130	N.S8.03
Van-der-waals	TM5	H	223	5x68	s15s16	F	245	C.s15s16.03
Van-der-waals	TM5	Q	230	5x75	s17s18	V	315	C.s17s18.40

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Main reference

Beta-arrestin-2 - GPR3 complex model Download Full