Arrestin-C - GPR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPR3 76.6
Arrestin-C 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 R 231 5x76 S6 L 75 N.S6.05
Hydrophobic TM5 R 231 5x76 S6 L 75 N.S6.05
Van-der-waals TM5 R 231 5x76 S6 L 75 N.S6.05
Polar TM5 R 231 5x76 S6 D 74 N.S6.04
Hydrophobic TM5 R 231 5x76 S6 D 74 N.S6.04
Van-der-waals TM5 R 231 5x76 S6 D 74 N.S6.04
Hydrophobic TM5 I 216 5x61 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 I 216 5x61 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 Y 145 34x54 s5s6 G 60 N.s5s6.01
Hydrophobic C-term V 330 - s8s9 K 135 N.s8s9.09
Van-der-waals C-term V 330 - s8s9 K 135 N.s8s9.09
Polar TM5 Q 226 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 Q 226 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 Q 226 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic ICL2 L 142 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 142 34x51 S15 V 238 C.S15.14
Hydrophobic TM6 V 252 6x40 s5s6 I 67 N.s5s6.08
Hydrophobic C-term R 323 - s20c A 379 C.s20c.12
Van-der-waals C-term R 323 - s20c A 379 C.s20c.12
Van-der-waals TM3 R 134 3x50 s5s6 V 66 N.s5s6.07
Ionic TM6 H 238 6x26 S6 D 74 N.S6.04
Polar TM6 H 238 6x26 S6 D 74 N.S6.04
Hydrophobic TM6 H 238 6x26 S6 D 74 N.S6.04
Van-der-waals TM6 H 238 6x26 S6 D 74 N.S6.04
Polar ICL2 A 141 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 A 141 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 A 141 34x50 S5 Y 59 N.S5.12
Polar C-term P 327 - s17s18 K 289 C.s17s18.18
Van-der-waals C-term P 327 - s17s18 K 289 C.s17s18.18
Polar TM3 Y 139 3x55 S5 Y 59 N.S5.12
Hydrophobic TM7 Y 297 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 297 7x53 s5s6 V 66 N.s5s6.07
Polar TM5 Q 230 5x75 s17s18 D 308 C.s17s18.37
Hydrophobic TM5 Q 230 5x75 s17s18 D 308 C.s17s18.37
Van-der-waals TM5 Q 230 5x75 s17s18 D 308 C.s17s18.37
Polar TM3 S 137 3x53 S5 Y 59 N.S5.12
Hydrophobic TM3 S 137 3x53 S5 Y 59 N.S5.12
Van-der-waals TM3 S 137 3x53 S5 Y 59 N.S5.12
Polar ICL2 A 141 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 A 141 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 A 141 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 142 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 L 142 34x51 S9 C 137 N.S9.01
Polar ICL2 L 142 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 L 142 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 142 34x51 S16 Y 246 C.S16.03
Hydrophobic TM3 L 138 3x54 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 231 5x76 S6 V 77 N.S6.07
Van-der-waals TM5 R 231 5x76 S6 V 77 N.S6.07
Hydrophobic TM6 L 249 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 249 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals C-term S 328 - s17s18 K 289 C.s17s18.18
Hydrophobic TM6 G 245 6x33 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 G 245 6x33 s5s6 G 68 N.s5s6.09
Polar ICL2 T 143 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL2 T 143 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 T 143 34x52 S16 Y 246 C.S16.03
Hydrophobic TM2 M 75 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 M 75 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 T 248 6x36 s5s6 I 67 N.s5s6.08
Polar TM3 Y 139 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 Y 139 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 Y 139 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 Y 145 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 Y 145 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic TM7 I 296 7x52 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 I 296 7x52 s5s6 V 66 N.s5s6.07
Hydrophobic H8 N 301 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 301 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 M 75 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 M 75 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic C-term S 324 - s8s9 A 133 N.s8s9.07
Hydrophobic TM3 R 134 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 134 3x50 s5s6 I 67 N.s5s6.08
Polar ICL2 Y 145 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic C-term P 327 - s8s9 P 136 N.s8s9.10
Polar ICL2 T 143 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 L 142 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 L 142 34x51 S8 L 126 N.S8.03
Polar ICL2 Y 145 34x54 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 Y 145 34x54 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 Y 145 34x54 s17s18 R 282 C.s17s18.11
Polar TM5 R 231 5x76 S6 Y 76 N.S6.06
Hydrophobic TM5 R 231 5x76 S6 Y 76 N.S6.06
Van-der-waals TM5 R 231 5x76 S6 Y 76 N.S6.06
Van-der-waals TM5 I 227 5x72 S6 D 74 N.S6.04
Hydrophobic TM5 Y 213 5x58 s5s6 I 67 N.s5s6.08
Hydrophobic TM4 S 146 4x35 s17s18 R 282 C.s17s18.11
Van-der-waals TM4 S 146 4x35 s17s18 R 282 C.s17s18.11
Hydrophobic TM3 S 137 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 S 137 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 L 142 34x51 S16 D 244 C.S16.01
Hydrophobic TM5 V 220 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 V 220 5x65 s5s6 L 69 N.s5s6.10
Polar TM5 H 223 5x68 s15s16 Y 241 C.s15s16.03
Aromatic TM5 H 223 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 223 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 223 5x68 s15s16 Y 241 C.s15s16.03
Polar TM5 H 223 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 H 223 5x68 S6 K 73 N.S6.03
Hydrophobic TM6 H 238 6x26 S6 K 73 N.S6.03
Polar C-term R 323 - s20c S 376 C.s20c.09
Van-der-waals C-term R 323 - s20c S 376 C.s20c.09
Hydrophobic TM2 P 74 2x38 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 R 134 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 P 235 6x23 S6 V 77 N.S6.07
Polar C-term V 330 - S10 R 162 N.S10.03
Hydrophobic C-term V 330 - S10 R 162 N.S10.03
Van-der-waals C-term V 330 - S10 R 162 N.S10.03
Hydrophobic TM5 Q 230 5x75 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 Q 230 5x75 s17s18 L 311 C.s17s18.40
Polar C-term S 326 - s17s18 K 291 C.s17s18.20
Hydrophobic TM3 L 138 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM2 A 73 2x37 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 A 73 2x37 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 L 138 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 L 138 3x54 S6 F 71 N.S6.01
Polar C-term S 328 - s17s18 K 291 C.s17s18.20
Hydrophobic TM2 M 75 2x39 s5s6 L 64 N.s5s6.05
Polar TM3 L 138 3x54 S5 Y 59 N.S5.12
Hydrophobic TM3 L 138 3x54 S5 Y 59 N.S5.12
Van-der-waals TM3 L 138 3x54 S5 Y 59 N.S5.12
Hydrophobic TM5 I 219 5x64 s15s16 Y 241 C.s15s16.03
Polar ICL2 A 141 34x50 S16 D 244 C.S16.01
Hydrophobic TM3 N 140 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 N 140 3x56 S16 D 244 C.S16.01
Hydrophobic TM5 I 227 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 I 227 5x72 S6 K 73 N.S6.03
Polar TM5 Q 226 5x71 S6 K 73 N.S6.03
Polar C-term P 327 - s8s9 K 135 N.s8s9.09
Hydrophobic C-term P 327 - s8s9 K 135 N.s8s9.09
Van-der-waals C-term P 327 - s8s9 K 135 N.s8s9.09
Polar ICL2 Y 145 34x54 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 Y 145 34x54 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 Y 145 34x54 s8s9 G 134 N.s8s9.08
Polar ICL2 Y 145 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 Y 145 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Y 145 34x54 s5s6 R 61 N.s5s6.02