S-arrestin - GPR45 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR45 73.0
S-arrestin 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL1 A 64 12x49 s5s6 I 76 N.s5s6.05
Van-der-waals ICL1 A 64 12x49 s5s6 I 76 N.s5s6.05
Polar H8 K 330 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 K 330 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 K 330 8x49 s5s6 D 75 N.s5s6.04
Polar ICL2 Q 140 - s15s16 Y 254 C.s15s16.03
Polar ICL3 Q 254 - S6 L 87 N.S6.05
Hydrophobic ICL3 Q 254 - S6 L 87 N.S6.05
Van-der-waals ICL3 Q 254 - S6 L 87 N.S6.05
Hydrophobic ICL2 R 139 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 R 139 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 F 261 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 L 272 6x40 s5s6 I 79 N.s5s6.08
Hydrophobic ICL1 M 65 12x50 s5s6 D 75 N.s5s6.04
Polar C-term E 367 - s19s20 N 376 C.s19s20.51
Hydrophobic C-term E 367 - s19s20 N 376 C.s19s20.51
Van-der-waals C-term E 367 - s19s20 N 376 C.s19s20.51
Hydrophobic TM6 F 261 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 F 261 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 F 261 6x29 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 F 261 6x29 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 R 139 - s15s16 S 255 C.s15s16.04
Hydrophobic TM2 N 70 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 70 2x40 s5s6 V 78 N.s5s6.07
Ionic TM6 D 258 6x26 S6 R 85 N.S6.03
Polar TM6 D 258 6x26 S6 R 85 N.S6.03
Hydrophobic TM6 D 258 6x26 S6 R 85 N.S6.03
Van-der-waals TM6 D 258 6x26 S6 R 85 N.S6.03
Hydrophobic TM2 I 69 2x39 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 132 3x50 S6 F 83 N.S6.01
Van-der-waals TM3 R 132 3x50 S6 F 83 N.S6.01
Hydrophobic C-term I 353 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term I 353 - s1s2 R 22 N.s1s2.02
Polar ICL2 D 141 - S5 Y 71 N.S5.12
Hydrophobic ICL2 D 141 - S5 Y 71 N.S5.12
Van-der-waals ICL2 D 141 - S5 Y 71 N.S5.12
Polar ICL3 Q 250 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 Q 250 - s7s8 Y 129 N.s7s8.05
Hydrophobic TM6 T 268 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 268 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 135 3x53 s15s16 Y 254 C.s15s16.03
Hydrophobic C-term I 357 - s20c A 383 C.s20c.02
Van-der-waals C-term I 357 - s20c A 383 C.s20c.02
Hydrophobic C-term Y 363 - S20 V 378 C.S20.02
Hydrophobic ICL1 M 65 12x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 I 128 3x46 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 I 128 3x46 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 136 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 136 3x54 S6 F 83 N.S6.01
Hydrophobic ICL3 Q 254 - S6 D 86 N.S6.04
Van-der-waals ICL3 Q 254 - S6 D 86 N.S6.04
Polar TM6 K 262 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 K 262 6x30 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 K 262 6x30 s15s16 Y 254 C.s15s16.03
Polar TM4 R 146 4x40 s8s9 Q 141 N.s8s9.05
Van-der-waals TM4 R 146 4x40 s8s9 Q 141 N.s8s9.05
Ionic H8 E 333 8x52 s9s10 K 170 N.s9s10.12
Hydrophobic TM2 I 69 2x39 s5s6 L 81 N.s5s6.10
Van-der-waals TM2 I 69 2x39 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 F 261 6x29 S6 F 83 N.S6.01
Hydrophobic TM6 F 261 6x29 S6 R 84 N.S6.02
Van-der-waals TM6 F 261 6x29 S6 R 84 N.S6.02
Hydrophobic TM6 I 269 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 V 257 6x25 S6 D 86 N.S6.04
Van-der-waals TM6 V 257 6x25 S6 D 86 N.S6.04
Aromatic C-term Y 363 - S1 K 18 N.S1.03
Hydrophobic C-term Y 363 - S1 K 18 N.S1.03
Van-der-waals C-term Y 363 - S1 K 18 N.S1.03
Hydrophobic C-term P 359 - s20c R 384 C.s20c.03
Hydrophobic TM3 R 132 3x50 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 R 132 3x50 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 S 67 2x37 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 S 67 2x37 s5s6 I 76 N.s5s6.05
Polar TM6 A 265 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 A 265 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 A 265 6x33 s5s6 G 80 N.s5s6.09
Polar H8 K 330 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 K 330 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals C-term P 359 - s20c A 383 C.s20c.02
Polar C-term Y 363 - S20 F 379 C.S20.03
Hydrophobic C-term Y 363 - S20 F 379 C.S20.03
Van-der-waals C-term Y 363 - S20 F 379 C.S20.03
Hydrophobic TM3 I 135 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 I 135 3x53 S6 F 83 N.S6.01
Hydrophobic TM2 L 73 2x43 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 L 73 2x43 s5s6 I 79 N.s5s6.08
Hydrophobic C-term P 359 - s20c H 385 C.s20c.04
Van-der-waals C-term P 359 - s20c H 385 C.s20c.04
Hydrophobic TM2 N 70 2x40 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 N 70 2x40 s5s6 I 76 N.s5s6.05
Ionic TM6 K 264 6x32 s9s10 D 166 N.s9s10.08
Polar TM6 K 264 6x32 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 264 6x32 s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 Q 254 - S6 Y 88 N.S6.06
Van-der-waals ICL3 Q 254 - S6 Y 88 N.S6.06
Hydrophobic ICL3 Q 250 - s7s8 P 127 N.s7s8.03
Van-der-waals ICL3 Q 250 - s7s8 P 127 N.s7s8.03
Polar ICL3 Q 254 - s7s8 Y 129 N.s7s8.05
Hydrophobic ICL3 Q 254 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 Q 254 - s7s8 Y 129 N.s7s8.05
Polar ICL1 A 64 12x49 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL1 A 64 12x49 s5s6 Q 73 N.s5s6.02
Hydrophobic H8 K 330 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 330 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 I 328 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 I 328 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic C-term V 362 - S20 V 378 C.S20.02
Van-der-waals C-term V 362 - S20 V 378 C.S20.02
Polar TM6 D 258 6x26 s15s16 Y 254 C.s15s16.03
Hydrophobic C-term C 365 - S20 F 379 C.S20.03
Van-der-waals C-term C 365 - S20 F 379 C.S20.03
Polar ICL3 Q 250 - S6 Y 88 N.S6.06
Hydrophobic ICL3 Q 250 - S6 Y 88 N.S6.06
Ionic ICL2 D 141 - s8s9 K 145 N.s8s9.09
Polar ICL2 D 141 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 D 141 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 D 141 - s8s9 K 145 N.s8s9.09
Hydrophobic H8 I 328 8x47 s5s6 I 79 N.s5s6.08
Polar C-term C 365 - H1 K 114 N.H1.09
Hydrophobic C-term C 365 - H1 K 114 N.H1.09
Van-der-waals C-term C 365 - H1 K 114 N.H1.09
Hydrophobic ICL1 M 65 12x50 s5s6 I 76 N.s5s6.05
Van-der-waals ICL1 M 65 12x50 s5s6 I 76 N.s5s6.05
Hydrophobic TM6 F 261 6x29 s5s6 D 77 N.s5s6.06
Van-der-waals TM6 F 261 6x29 s5s6 D 77 N.s5s6.06
Hydrophobic ICL3 Q 253 - S6 F 89 N.S6.07
Van-der-waals ICL3 Q 253 - S6 F 89 N.S6.07
Hydrophobic H8 I 328 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 I 328 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 L 73 2x43 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 L 73 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 A 265 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 265 6x33 s5s6 L 81 N.s5s6.10
Ionic ICL3 R 239 - s7s8 D 128 N.s7s8.04
Polar ICL3 R 239 - s7s8 D 128 N.s7s8.04
Van-der-waals ICL3 R 239 - s7s8 D 128 N.s7s8.04