Arrestin-C - GPR4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR4 75.0
Arrestin-C 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 L 123 34x51 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 L 123 34x51 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 L 123 34x51 s8s9 G 134 N.s8s9.08
Hydrophobic TM5 I 204 5x61 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 I 204 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 V 119 3x54 S6 F 71 N.S6.01
Hydrophobic TM3 A 118 3x53 s5s6 V 66 N.s5s6.07
Ionic TM2 E 51 2x38 s8s9 K 135 N.s8s9.09
Polar ICL3 V 212 - S6 K 73 N.S6.03
Hydrophobic ICL3 V 212 - S6 K 73 N.S6.03
Van-der-waals ICL3 V 212 - S6 K 73 N.S6.03
Hydrophobic TM3 V 119 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 V 119 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 123 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 123 34x51 S16 D 244 C.S16.01
Polar ICL2 R 124 34x52 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 R 124 34x52 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 R 124 34x52 s8s9 A 133 N.s8s9.07
Polar ICL2 L 123 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 L 123 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 123 34x51 S16 Y 246 C.S16.03
Hydrophobic TM5 Y 201 5x58 s5s6 I 67 N.s5s6.08
Polar TM7 E 291 7x58 s5s6 E 65 N.s5s6.06
Hydrophobic TM7 E 291 7x58 s5s6 E 65 N.s5s6.06
Van-der-waals TM7 E 291 7x58 s5s6 E 65 N.s5s6.06
Polar ICL1 R 49 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL1 R 49 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 R 49 - s5s6 R 61 N.s5s6.02
Hydrophobic TM3 A 118 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 118 3x53 S6 F 71 N.S6.01
Hydrophobic ICL2 A 126 34x54 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 A 126 34x54 s8s9 G 134 N.s8s9.08
Hydrophobic TM3 R 115 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 115 3x50 s5s6 V 66 N.s5s6.07
Polar ICL2 L 123 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 L 123 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 123 34x51 S5 Y 59 N.S5.12
Polar ICL2 A 126 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 A 126 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 A 126 34x54 s8s9 A 133 N.s8s9.07
Polar ICL3 S 213 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 S 213 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 S 213 - s15s16 Y 241 C.s15s16.03
Polar ICL2 R 127 34x55 s8s9 P 130 N.s8s9.04
Hydrophobic ICL2 R 127 34x55 s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 R 127 34x55 s8s9 P 130 N.s8s9.04
Hydrophobic ICL2 A 126 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic TM6 L 225 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 225 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 N 50 2x37 s5s6 L 64 N.s5s6.05
Van-der-waals TM2 N 50 2x37 s5s6 L 64 N.s5s6.05
Van-der-waals ICL2 L 123 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL3 T 214 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL3 T 214 - s5s6 L 69 N.s5s6.10
Polar ICL3 T 214 - s15s16 Y 241 C.s15s16.03
Polar ICL2 L 123 34x51 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 L 123 34x51 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 L 123 34x51 s8s9 A 133 N.s8s9.07
Ionic ICL2 R 124 34x52 S16 D 244 C.S16.01
Polar ICL2 R 124 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 R 124 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 R 124 34x52 S16 D 244 C.S16.01
Hydrophobic ICL3 V 212 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 V 212 - s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 S 213 - S6 K 73 N.S6.03
Van-der-waals ICL3 S 213 - S6 K 73 N.S6.03
Hydrophobic TM6 I 222 6x33 s5s6 I 67 N.s5s6.08
Polar ICL2 F 125 34x53 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 F 125 34x53 s8s9 A 133 N.s8s9.07
Polar TM7 N 290 7x57 s5s6 E 65 N.s5s6.06
Hydrophobic TM7 N 290 7x57 s5s6 E 65 N.s5s6.06
Van-der-waals TM7 N 290 7x57 s5s6 E 65 N.s5s6.06
Hydrophobic ICL3 S 213 - s15s16 L 240 C.s15s16.02
Van-der-waals ICL3 S 213 - s15s16 L 240 C.s15s16.02
Hydrophobic TM2 L 52 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 E 218 6x29 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 I 222 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 I 222 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 R 129 34x57 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 R 129 34x57 s8s9 K 135 N.s8s9.09
Polar TM7 G 292 7x59 s5s6 E 65 N.s5s6.06
Van-der-waals TM7 G 292 7x59 s5s6 E 65 N.s5s6.06
Polar TM6 E 218 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 L 123 34x51 S15 V 238 C.S15.14
Polar ICL2 P 122 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 122 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 122 34x50 S5 Y 59 N.S5.12
Hydrophobic TM5 V 208 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 123 34x51 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 L 123 34x51 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 P 122 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 122 34x50 s15s16 S 242 C.s15s16.04
Polar ICL2 P 122 34x50 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 P 122 34x50 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 P 122 34x50 s8s9 K 135 N.s8s9.09
Ionic TM2 E 51 2x38 s5s6 R 61 N.s5s6.02
Ionic ICL2 R 127 34x55 s8s9 E 131 N.s8s9.05
Polar ICL2 R 127 34x55 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 R 127 34x55 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 R 127 34x55 s8s9 E 131 N.s8s9.05
Hydrophobic TM3 R 115 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 115 3x50 s5s6 I 67 N.s5s6.08