Beta-arrestin-2 - GPR52 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR52 72.4
Beta-arrestin-2 77.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 146 34x50 s15s16 S 246 C.s15s16.04
Ionic TM5 E 236 5x72 S6 K 78 N.S6.03
Polar TM5 E 236 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 E 236 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 E 236 5x72 S6 K 78 N.S6.03
Polar ICL2 L 147 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 147 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 147 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 D 260 6x30 S6 F 76 N.S6.01
Van-der-waals TM5 H 233 5x69 s15s16 F 245 C.s15s16.03
Polar TM5 H 233 5x69 s15s16 F 245 C.s15s16.03
Aromatic TM5 H 233 5x69 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 233 5x69 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 I 237 5x73 S6 K 78 N.S6.03
Van-der-waals TM5 I 237 5x73 S6 K 78 N.S6.03
Hydrophobic ICL2 P 146 34x50 S15 I 242 C.S15.14
Polar TM2 T 75 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 135 3x46 s5s6 L 72 N.s5s6.08
Polar TM5 R 240 5x76 s17s18 V 315 C.s17s18.40
Hydrophobic TM5 R 240 5x76 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 R 240 5x76 s17s18 V 315 C.s17s18.40
Hydrophobic TM5 F 244 5x80 s7s8 N 123 N.s7s8.05
Van-der-waals TM5 F 244 5x80 s7s8 N 123 N.s7s8.05
Van-der-waals TM6 D 260 6x30 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 I 270 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 139 3x50 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 L 267 6x37 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 267 6x37 s5s6 L 74 N.s5s6.10
Polar TM3 I 143 3x54 S5 Y 64 N.S5.12
Hydrophobic TM3 I 143 3x54 S5 Y 64 N.S5.12
Van-der-waals TM3 I 143 3x54 S5 Y 64 N.S5.12
Polar TM6 S 252 6x22 s9s10 E 156 N.s9s10.07
Polar ICL2 N 150 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 N 150 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 N 150 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM6 A 264 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 139 3x50 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 R 139 3x50 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 L 147 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 L 147 34x51 S9 C 141 N.S9.01
Hydrophobic ICL1 L 71 12x50 s5s6 V 71 N.s5s6.07
Polar ICL2 S 148 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 S 148 34x52 S16 Y 250 C.S16.03
Polar C-term C 359 - s1s2 C 17 N.s1s2.04
Hydrophobic C-term C 359 - s1s2 C 17 N.s1s2.04
Van-der-waals C-term C 359 - s1s2 C 17 N.s1s2.04
Hydrophobic TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Polar ICL3 E 248 - s6h1 N 93 N.s6h1.06
Hydrophobic ICL3 E 248 - s6h1 N 93 N.s6h1.06
Van-der-waals ICL3 E 248 - s6h1 N 93 N.s6h1.06
Hydrophobic ICL2 L 147 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 L 147 34x51 S8 L 130 N.S8.03
Polar TM3 T 144 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 T 144 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 T 144 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 L 267 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 267 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 E 254 6x24 s9s10 E 156 N.s9s10.07
Hydrophobic TM3 I 143 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 143 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 T 76 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 T 76 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 A 142 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 142 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 P 146 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 146 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 146 34x50 S5 Y 64 N.S5.12
Ionic TM3 R 139 3x50 s5s6 D 68 N.s5s6.04
Polar TM3 R 139 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 139 3x50 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 139 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 C 230 5x66 S6 F 76 N.S6.01
Hydrophobic TM5 H 233 5x69 s15s16 L 244 C.s15s16.02
Polar C-term I 361 - S1 K 11 N.S1.03
Van-der-waals C-term I 361 - S1 K 11 N.S1.03
Hydrophobic TM5 R 240 5x76 S6 K 78 N.S6.03
Polar TM5 H 233 5x69 S6 K 78 N.S6.03
Hydrophobic H8 N 321 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 N 321 8x47 s5s6 V 71 N.s5s6.07
Polar TM2 Y 74 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 Y 74 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 Y 74 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 143 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 143 3x54 S6 F 76 N.S6.01
Hydrophobic TM5 R 240 5x76 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 R 240 5x76 s15s16 L 244 C.s15s16.02
Hydrophobic TM5 R 240 5x76 S6 L 80 N.S6.05
Van-der-waals TM5 R 240 5x76 S6 L 80 N.S6.05
Hydrophobic C-term C 359 - S1 S 13 N.S1.05
Van-der-waals C-term C 359 - S1 S 13 N.S1.05
Hydrophobic ICL1 H 73 12x52 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 Y 74 2x37 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 Y 74 2x37 s5s6 V 71 N.s5s6.07
Polar ICL2 N 150 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 N 150 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 N 150 34x54 s5s6 R 66 N.s5s6.02
Ionic TM5 R 240 5x76 s17s18 E 314 C.s17s18.39
Polar TM5 R 240 5x76 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 R 240 5x76 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 R 240 5x76 s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 L 147 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 147 34x51 S15 I 242 C.S15.14
Polar TM6 D 260 6x30 S6 R 77 N.S6.02
Hydrophobic TM6 Y 263 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 Y 263 6x33 s5s6 G 73 N.s5s6.09
Polar TM2 Y 74 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 Y 74 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 Y 74 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 L 70 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 L 70 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL2 Y 149 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 149 34x53 s5s6 R 66 N.s5s6.02
Polar ICL3 S 246 - S6 I 82 N.S6.07
Polar TM6 Y 263 6x33 s5s6 D 70 N.s5s6.06