ArrestinDb

Beta-arrestin-1 - GPR55 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
GPR55	79.4
Beta-arrestin-1	78.2

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 19.9

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	ICL3	H	214	-	S6	K	77	N.S6.03
Aromatic	TM5	R	211	5x68	S6	F	75	N.S6.01
Aromatic	ICL2	H	131	34x55	s17s18	R	285	C.s17s18.11
Hydrophobic	H8	S	305	8x60	s9s10	H	159	N.s9s10.11
Hydrophobic	C-term	V	307	-	s9s10	R	161	N.s9s10.13
Hydrophobic	ICL2	P	126	34x50	S5	Y	63	N.S5.12
Hydrophobic	ICL3	H	214	-	S6	K	77	N.S6.03
Hydrophobic	TM5	L	208	5x65	S6	F	75	N.S6.01
Hydrophobic	TM5	L	208	5x65	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL1	D	55	-	s5s6	D	69	N.s5s6.06
Hydrophobic	ICL2	L	127	34x51	S15	I	241	C.S15.14
Hydrophobic	ICL1	D	55	-	s5s6	D	67	N.s5s6.04
Hydrophobic	ICL2	L	127	34x51	S16	Y	249	C.S16.03
Hydrophobic	ICL2	H	131	34x55	s8s9	P	131	N.s8s9.02
Hydrophobic	H8	P	304	8x59	s9s10	K	160	N.s9s10.12
Hydrophobic	C-term	L	309	-	s1s2	P	14	N.s1s2.02
Hydrophobic	ICL2	L	127	34x51	S8	L	129	N.S8.03
Hydrophobic	H8	H	302	8x57	s5s6	E	66	N.s5s6.03
Hydrophobic	H8	H	302	8x57	s5s6	T	74	N.s5s6.11
Hydrophobic	TM6	Q	216	6x25	S6	D	78	N.S6.04
Hydrophobic	ICL2	R	133	34x57	s5s6	D	69	N.s5s6.06
Hydrophobic	H8	E	294	8x49	s5s6	G	72	N.s5s6.09
Hydrophobic	ICL1	Y	56	-	s5s6	D	69	N.s5s6.06
Hydrophobic	TM5	R	211	5x68	S6	F	75	N.S6.01
Hydrophobic	H8	N	298	8x53	s5s6	G	72	N.s5s6.09
Hydrophobic	C-term	V	307	-	s9s10	H	159	N.s9s10.11
Hydrophobic	TM6	S	227	6x36	s5s6	L	71	N.s5s6.08
Hydrophobic	H8	F	295	8x50	s5s6	D	69	N.s5s6.06
Hydrophobic	ICL2	P	126	34x50	s5s6	L	68	N.s5s6.05
Hydrophobic	TM3	R	124	3x55	s15s16	N	245	C.s15s16.04
Hydrophobic	H8	R	303	8x58	s9s10	K	160	N.s9s10.12
Hydrophobic	ICL2	S	130	34x54	s5s6	R	65	N.s5s6.02
Hydrophobic	ICL2	H	131	34x55	s17s18	R	285	C.s17s18.11
Hydrophobic	ICL2	L	127	34x51	S5	Y	63	N.S5.12
Hydrophobic	C-term	L	309	-	s1s2	N	15	N.s1s2.03
Hydrophobic	TM3	R	119	3x50	s5s6	L	71	N.s5s6.08
Hydrophobic	TM5	R	211	5x68	s15s16	F	244	C.s15s16.03
Hydrophobic	ICL2	P	126	34x50	s5s6	G	64	N.s5s6.01
Hydrophobic	TM3	I	123	3x54	s5s6	L	73	N.s5s6.10
Hydrophobic	TM6	T	215	6x24	S6	F	75	N.S6.01
Hydrophobic	TM6	T	215	6x24	s15s16	F	244	C.s15s16.03
Hydrophobic	TM7	V	291	7x56	s5s6	L	71	N.s5s6.08
Hydrophobic	C-term	Q	308	-	s9s10	R	161	N.s9s10.13
Hydrophobic	TM7	F	290	7x55	s5s6	L	71	N.s5s6.08
Hydrophobic	TM3	I	123	3x54	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL3	H	214	-	s15s16	F	244	C.s15s16.03
Hydrophobic	TM3	A	122	3x53	s5s6	V	70	N.s5s6.07
Hydrophobic	TM6	C	224	6x33	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL3	H	214	-	s15s16	L	243	C.s15s16.02
Hydrophobic	TM3	Y	125	3x56	s15s16	N	245	C.s15s16.04
Hydrophobic	TM6	Q	221	6x30	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL2	S	130	34x54	s8s9	D	135	N.s8s9.06
Hydrophobic	TM6	Q	221	6x30	S6	F	75	N.S6.01
Hydrophobic	C-term	L	309	-	s9s10	R	161	N.s9s10.13
Hydrophobic	TM3	R	119	3x50	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL2	H	131	34x55	s8s9	G	132	N.s8s9.03
Hydrophobic	ICL2	L	127	34x51	S9	C	140	N.S9.01
Hydrophobic	H8	F	295	8x50	s5s6	L	71	N.s5s6.08
Hydrophobic	TM6	Q	220	6x29	s5s6	G	72	N.s5s6.09
Hydrophobic	H8	E	294	8x49	s5s6	L	71	N.s5s6.08
Hydrophobic	ICL2	H	131	34x55	s8s9	D	135	N.s8s9.06
Ionic	H8	H	302	8x57	s5s6	E	66	N.s5s6.03
Ionic	ICL2	H	131	34x55	s8s9	D	135	N.s8s9.06
Polar	H8	S	305	8x60	s9s10	H	159	N.s9s10.11
Polar	C-term	V	307	-	s9s10	R	161	N.s9s10.13
Polar	ICL2	P	126	34x50	S5	Y	63	N.S5.12
Polar	ICL3	H	214	-	S6	K	77	N.S6.03
Polar	H8	H	302	8x57	s9s10	K	160	N.s9s10.12
Polar	H8	S	305	8x60	s9s10	K	160	N.s9s10.12
Polar	TM6	Q	216	6x25	S6	R	76	N.S6.02
Polar	H8	A	301	8x56	s9s10	K	160	N.s9s10.12
Polar	TM6	Q	216	6x25	S6	D	78	N.S6.04
Polar	ICL2	R	133	34x57	s5s6	D	69	N.s5s6.06
Polar	H8	E	294	8x49	s5s6	G	72	N.s5s6.09
Polar	ICL1	Y	56	-	s5s6	D	69	N.s5s6.06
Polar	H8	N	298	8x53	s5s6	G	72	N.s5s6.09
Polar	TM3	R	124	3x55	s15s16	N	245	C.s15s16.04
Polar	H8	R	303	8x58	s9s10	K	160	N.s9s10.12
Polar	ICL2	S	130	34x54	s5s6	R	65	N.s5s6.02
Polar	ICL2	H	131	34x55	s17s18	R	285	C.s17s18.11
Polar	H8	S	305	8x60	s9s10	R	161	N.s9s10.13
Polar	TM5	R	211	5x68	s15s16	F	244	C.s15s16.03
Polar	C-term	Q	308	-	s9s10	R	161	N.s9s10.13
Polar	H8	E	294	8x49	s5s6	L	73	N.s5s6.10
Polar	ICL2	S	130	34x54	s8s9	D	135	N.s8s9.06
Polar	TM6	Q	220	6x29	s5s6	T	74	N.s5s6.11
Polar	ICL2	H	131	34x55	s8s9	G	132	N.s8s9.03
Polar	H8	F	295	8x50	s5s6	L	71	N.s5s6.08
Polar	TM6	Q	220	6x29	s5s6	G	72	N.s5s6.09
Polar	TM2	T	59	2x39	s5s6	D	69	N.s5s6.06
Polar	ICL2	H	131	34x55	s8s9	D	135	N.s8s9.06
Van-der-waals	H8	S	305	8x60	s9s10	H	159	N.s9s10.11
Van-der-waals	C-term	V	307	-	s9s10	R	161	N.s9s10.13
Van-der-waals	ICL2	P	126	34x50	S5	Y	63	N.S5.12
Van-der-waals	ICL3	H	214	-	S6	K	77	N.S6.03
Van-der-waals	TM5	L	208	5x65	S6	F	75	N.S6.01
Van-der-waals	H8	H	302	8x57	s9s10	K	160	N.s9s10.12
Van-der-waals	TM5	L	208	5x65	s5s6	L	73	N.s5s6.10
Van-der-waals	ICL1	D	55	-	s5s6	D	69	N.s5s6.06
Van-der-waals	ICL2	L	127	34x51	S15	I	241	C.S15.14
Van-der-waals	ICL1	D	55	-	s5s6	D	67	N.s5s6.04
Van-der-waals	ICL2	L	127	34x51	S16	Y	249	C.S16.03
Van-der-waals	H8	P	304	8x59	s9s10	K	160	N.s9s10.12
Van-der-waals	C-term	L	309	-	s1s2	P	14	N.s1s2.02
Van-der-waals	ICL3	H	214	-	S6	R	76	N.S6.02
Van-der-waals	ICL2	L	127	34x51	S8	L	129	N.S8.03
Van-der-waals	H8	A	301	8x56	s9s10	K	160	N.s9s10.12
Van-der-waals	TM6	Q	216	6x25	S6	D	78	N.S6.04
Van-der-waals	ICL2	R	133	34x57	s5s6	D	69	N.s5s6.06
Van-der-waals	H8	E	294	8x49	s5s6	G	72	N.s5s6.09
Van-der-waals	ICL1	Y	56	-	s5s6	D	69	N.s5s6.06
Van-der-waals	TM5	R	211	5x68	S6	F	75	N.S6.01
Van-der-waals	H8	N	298	8x53	s5s6	G	72	N.s5s6.09
Van-der-waals	C-term	V	307	-	s9s10	H	159	N.s9s10.11
Van-der-waals	TM6	S	227	6x36	s5s6	L	71	N.s5s6.08
Van-der-waals	H8	F	295	8x50	s5s6	D	69	N.s5s6.06
Van-der-waals	ICL2	P	126	34x50	s5s6	L	68	N.s5s6.05
Van-der-waals	TM3	R	124	3x55	s15s16	N	245	C.s15s16.04
Van-der-waals	ICL2	S	130	34x54	s5s6	R	65	N.s5s6.02
Van-der-waals	ICL2	H	131	34x55	s17s18	R	285	C.s17s18.11
Van-der-waals	ICL2	L	127	34x51	S5	Y	63	N.S5.12
Van-der-waals	H8	S	305	8x60	s9s10	R	161	N.s9s10.13
Van-der-waals	C-term	L	309	-	s1s2	N	15	N.s1s2.03
Van-der-waals	TM3	R	119	3x50	s5s6	L	71	N.s5s6.08
Van-der-waals	TM5	R	211	5x68	s15s16	F	244	C.s15s16.03
Van-der-waals	TM6	T	215	6x24	s15s16	F	244	C.s15s16.03
Van-der-waals	TM7	V	291	7x56	s5s6	L	71	N.s5s6.08
Van-der-waals	C-term	Q	308	-	s9s10	R	161	N.s9s10.13
Van-der-waals	ICL3	H	214	-	s15s16	F	244	C.s15s16.03
Van-der-waals	TM3	A	122	3x53	s5s6	V	70	N.s5s6.07
Van-der-waals	TM6	T	215	6x24	S6	R	76	N.S6.02
Van-der-waals	TM6	C	224	6x33	s5s6	L	73	N.s5s6.10
Van-der-waals	TM3	Y	125	3x56	s15s16	N	245	C.s15s16.04
Van-der-waals	ICL2	S	130	34x54	s8s9	D	135	N.s8s9.06
Van-der-waals	TM6	Q	221	6x30	S6	F	75	N.S6.01
Van-der-waals	C-term	L	309	-	s9s10	R	161	N.s9s10.13
Van-der-waals	TM3	R	119	3x50	s5s6	V	70	N.s5s6.07
Van-der-waals	ICL2	H	131	34x55	s8s9	G	132	N.s8s9.03
Van-der-waals	ICL2	L	127	34x51	S9	C	140	N.S9.01
Van-der-waals	TM6	Q	220	6x29	s5s6	G	72	N.s5s6.09
Van-der-waals	H8	E	294	8x49	s5s6	L	71	N.s5s6.08
Van-der-waals	TM2	T	59	2x39	s5s6	D	69	N.s5s6.06
Van-der-waals	ICL2	H	131	34x55	s8s9	D	135	N.s8s9.06

Showing 1 to 143 of 143 entries

Join us

Cite us

Main reference

Beta-arrestin-1 - GPR55 complex model Download Full