Beta-arrestin-2 - GPR55 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR55 79.5
Beta-arrestin-2 78.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 H 131 34x55 s8s9 G 133 N.s8s9.03
Hydrophobic ICL2 H 131 34x55 s8s9 G 133 N.s8s9.03
Van-der-waals ICL2 H 131 34x55 s8s9 G 133 N.s8s9.03
Hydrophobic TM6 I 228 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 228 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 119 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 119 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 C 224 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 C 224 6x33 s5s6 L 72 N.s5s6.08
Polar ICL2 L 127 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 127 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 127 34x51 S16 Y 250 C.S16.03
Polar TM6 Q 216 6x25 S6 R 77 N.S6.02
Van-der-waals TM6 Q 216 6x25 S6 R 77 N.S6.02
Polar ICL2 H 131 34x55 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 H 131 34x55 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 H 131 34x55 s8s9 T 137 N.s8s9.07
Polar ICL2 S 130 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 S 130 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 S 130 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 126 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 126 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 127 34x51 s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 L 127 34x51 s8s9 K 139 N.s8s9.09
Polar ICL1 Y 56 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 Y 56 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 Y 56 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 S 130 34x54 s8s9 K 139 N.s8s9.09
Hydrophobic TM5 L 208 5x65 S6 F 76 N.S6.01
Polar ICL2 L 128 34x52 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 128 34x52 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 L 128 34x52 s8s9 T 137 N.s8s9.07
Polar ICL2 L 127 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 127 34x51 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 L 127 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 L 208 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 208 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 S 227 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 S 227 6x36 s5s6 L 72 N.s5s6.08
Polar TM5 R 211 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 211 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 211 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 P 126 34x50 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 D 55 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 D 55 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 127 34x51 S9 C 141 N.S9.01
Ionic TM3 R 119 3x50 s5s6 D 70 N.s5s6.06
Polar TM3 R 119 3x50 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 R 119 3x50 s5s6 D 70 N.s5s6.06
Van-der-waals TM3 R 119 3x50 s5s6 D 70 N.s5s6.06
Polar ICL2 V 129 34x53 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 V 129 34x53 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 V 129 34x53 s8s9 T 137 N.s8s9.07
Polar ICL2 P 126 34x50 s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 P 126 34x50 s8s9 K 139 N.s8s9.09
Van-der-waals ICL2 P 126 34x50 s8s9 K 139 N.s8s9.09
Polar ICL2 L 127 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 127 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 127 34x51 S5 Y 64 N.S5.12
Hydrophobic TM3 A 122 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 122 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 R 133 34x57 s5s6 L 69 N.s5s6.05
Polar ICL2 H 131 34x55 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 H 131 34x55 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 H 131 34x55 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 L 127 34x51 S16 A 248 C.S16.01
Polar ICL2 L 127 34x51 s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 L 127 34x51 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 L 127 34x51 s8s9 G 138 N.s8s9.08
Polar ICL2 H 131 34x55 s8s9 P 134 N.s8s9.04
Hydrophobic ICL2 H 131 34x55 s8s9 P 134 N.s8s9.04
Van-der-waals ICL2 H 131 34x55 s8s9 P 134 N.s8s9.04
Hydrophobic TM6 T 215 6x24 s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 H 214 - S6 R 77 N.S6.02
Hydrophobic TM3 R 119 3x50 s5s6 L 72 N.s5s6.08
Polar ICL2 H 131 34x55 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 H 131 34x55 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 H 131 34x55 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 H 214 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 H 214 - s15s16 F 245 C.s15s16.03
Hydrophobic TM3 I 123 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 H 131 34x55 s8s9 P 132 N.s8s9.02
Polar TM6 Q 216 6x25 S6 D 79 N.S6.04
Hydrophobic TM6 Q 216 6x25 S6 D 79 N.S6.04
Van-der-waals TM6 Q 216 6x25 S6 D 79 N.S6.04
Hydrophobic TM6 Q 221 6x30 s5s6 L 74 N.s5s6.10
Polar ICL3 H 214 - S6 K 78 N.S6.03
Hydrophobic ICL3 H 214 - S6 K 78 N.S6.03
Van-der-waals ICL3 H 214 - S6 K 78 N.S6.03
Hydrophobic TM3 I 123 3x54 s5s6 L 74 N.s5s6.10
Aromatic TM5 R 211 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 R 211 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 R 211 5x68 S6 F 76 N.S6.01
Polar H8 I 292 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 I 292 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 I 292 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 T 215 6x24 S6 F 76 N.S6.01
Polar ICL2 S 130 34x54 s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 S 130 34x54 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 S 130 34x54 s8s9 G 138 N.s8s9.08
Hydrophobic TM7 Y 288 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 288 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 P 126 34x50 S6 F 76 N.S6.01
Hydrophobic TM7 V 291 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 132 34x56 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 L 132 34x56 s8s9 T 137 N.s8s9.07
Polar TM6 Q 220 6x29 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 126 34x50 s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 P 126 34x50 s5s6 L 69 N.s5s6.05
Polar TM6 Q 220 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 Q 220 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 Q 220 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 Q 216 6x25 S6 I 82 N.S6.07
Hydrophobic TM6 C 224 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 C 224 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 M 63 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 M 63 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 127 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 127 34x51 S15 I 242 C.S15.14
Hydrophobic TM2 T 59 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 T 59 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 T 215 6x24 S6 R 77 N.S6.02
Ionic ICL1 D 55 - s5s6 R 66 N.s5s6.02
Polar ICL1 D 55 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL1 D 55 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL1 D 55 - s5s6 R 66 N.s5s6.02