Beta-arrestin-1 - GPR61 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR61 63.7
Beta-arrestin-1 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 148 34x51 s8s9 A 139 N.s8s9.10
Van-der-waals ICL2 M 148 34x51 s8s9 A 139 N.s8s9.10
Hydrophobic TM5 Y 228 5x58 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 Y 143 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 Y 143 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 M 148 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 M 148 34x51 S15 I 241 C.S15.14
Polar TM3 Y 143 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 Y 143 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 Y 143 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL3 W 248 - s7s8 P 120 N.s7s8.03
Ionic C-term E 379 - s9s10 K 157 N.s9s10.09
Polar C-term E 379 - s9s10 K 157 N.s9s10.09
Hydrophobic C-term E 379 - s9s10 K 157 N.s9s10.09
Van-der-waals C-term E 379 - s9s10 K 157 N.s9s10.09
Polar ICL2 M 148 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 M 148 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 M 148 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 M 148 34x51 S5 Y 63 N.S5.12
Polar TM5 H 242 5x72 S6 R 76 N.S6.02
Hydrophobic TM5 H 242 5x72 S6 R 76 N.S6.02
Van-der-waals TM5 H 242 5x72 S6 R 76 N.S6.02
Ionic H8 K 354 8x56 s20c E 407 C.s20c.17
Polar H8 K 354 8x56 s20c E 407 C.s20c.17
Hydrophobic H8 K 354 8x56 s20c E 407 C.s20c.17
Van-der-waals H8 K 354 8x56 s20c E 407 C.s20c.17
Ionic H8 R 346 8x48 s5s6 D 69 N.s5s6.06
Polar H8 R 346 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 R 346 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 R 346 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 V 288 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 288 6x36 s5s6 L 71 N.s5s6.08
Polar TM3 H 146 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 H 146 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 H 146 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 F 280 6x28 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 F 280 6x28 s5s6 L 73 N.s5s6.10
Polar TM5 Q 241 5x71 S6 K 77 N.S6.03
Hydrophobic TM5 Q 241 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 Q 241 5x71 S6 K 77 N.S6.03
Hydrophobic ICL3 M 249 - s7s8 L 123 N.s7s8.06
Van-der-waals ICL3 M 249 - s7s8 L 123 N.s7s8.06
Hydrophobic H8 N 345 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 L 245 5x75 S6 D 78 N.S6.04
Van-der-waals TM5 L 245 5x75 S6 D 78 N.S6.04
Hydrophobic ICL3 T 275 - S6 V 81 N.S6.07
Ionic ICL2 E 151 34x54 s5s6 R 65 N.s5s6.02
Polar ICL2 E 151 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 E 151 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 E 151 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 R 140 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 L 245 5x75 S6 L 79 N.S6.05
Van-der-waals TM5 L 245 5x75 S6 L 79 N.S6.05
Hydrophobic TM5 A 235 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 235 5x65 s5s6 L 73 N.s5s6.10
Polar C-term E 374 - s9s10 R 161 N.s9s10.13
Polar TM2 K 75 2x39 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 K 75 2x39 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 V 144 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 144 3x54 s5s6 L 68 N.s5s6.05
Ionic TM2 K 75 2x39 s5s6 D 67 N.s5s6.04
Polar TM2 K 75 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 K 75 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 K 75 2x39 s5s6 D 67 N.s5s6.04
Ionic ICL3 S 268 - s6h1 D 93 N.s6h1.07
Hydrophobic ICL2 M 148 34x51 S9 C 140 N.S9.01
Van-der-waals ICL2 M 148 34x51 S9 C 140 N.S9.01
Ionic C-term E 420 - S16 K 250 C.S16.04
Polar C-term E 420 - S16 K 250 C.S16.04
Van-der-waals C-term E 420 - S16 K 250 C.S16.04
Hydrophobic ICL3 M 249 - S6 L 79 N.S6.05
Van-der-waals ICL3 M 249 - S6 L 79 N.S6.05
Hydrophobic C-term R 373 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term R 373 - s9s10 R 161 N.s9s10.13
Hydrophobic TM5 H 242 5x72 S6 K 77 N.S6.03
Hydrophobic TM5 P 246 5x76 s17s18 I 314 C.s17s18.40
Van-der-waals TM5 P 246 5x76 s17s18 I 314 C.s17s18.40
Hydrophobic TM3 V 144 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 V 144 3x54 S6 F 75 N.S6.01
Hydrophobic ICL1 A 72 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 Q 273 - s9s10 L 154 N.s9s10.03
Van-der-waals ICL3 Q 273 - s9s10 L 154 N.s9s10.03
Hydrophobic ICL2 E 151 34x54 s8s9 A 139 N.s8s9.10
Hydrophobic TM5 A 235 5x65 S6 F 75 N.S6.01
Hydrophobic TM6 V 288 6x36 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 V 288 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 E 151 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 E 151 34x54 s8s9 P 131 N.s8s9.02
Hydrophobic ICL3 W 248 - s17s18 I 314 C.s17s18.40
Polar ICL2 E 151 34x54 s8s9 G 132 N.s8s9.03
Polar H8 Q 347 8x49 s8s9 T 136 N.s8s9.07
Polar ICL2 P 147 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 147 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 147 34x50 S5 Y 63 N.S5.12
Hydrophobic TM6 A 285 6x33 s5s6 L 73 N.s5s6.10
Polar ICL2 E 151 34x54 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 E 151 34x54 s17s18 R 285 C.s17s18.11
Polar C-term P 371 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term P 371 - s9s10 R 161 N.s9s10.13
Hydrophobic TM7 L 344 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 147 34x50 s5s6 G 64 N.s5s6.01
Hydrophobic TM6 A 285 6x33 s5s6 L 71 N.s5s6.08
Polar ICL2 R 149 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 R 149 34x52 S16 Y 249 C.S16.03
Polar C-term S 372 - s9s10 R 161 N.s9s10.13
Hydrophobic C-term S 372 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term S 372 - s9s10 R 161 N.s9s10.13
Hydrophobic TM5 A 238 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 A 238 5x68 s15s16 F 244 C.s15s16.03
Polar TM3 V 145 3x55 S5 Y 63 N.S5.12
Hydrophobic ICL3 W 248 - s7s8 N 122 N.s7s8.05
Hydrophobic TM2 F 76 2x40 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 F 76 2x40 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 V 144 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 245 5x75 S6 F 80 N.S6.06
Hydrophobic TM6 P 276 6x24 s9s10 E 155 N.s9s10.07
Hydrophobic TM5 M 231 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 M 231 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 F 280 6x28 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 E 151 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 E 151 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL3 W 248 - s7s8 L 123 N.s7s8.06
Polar TM3 Y 143 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 Y 143 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 Y 143 3x53 s5s6 D 67 N.s5s6.04
Polar TM3 V 145 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 V 145 3x55 s15s16 N 245 C.s15s16.04
Polar H8 Q 347 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic H8 Q 347 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 Q 347 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 V 152 34x55 S16 Y 249 C.S16.03
Polar ICL3 S 268 - s6h1 E 92 N.s6h1.06
Van-der-waals ICL3 S 268 - s6h1 E 92 N.s6h1.06
Hydrophobic TM5 V 234 5x64 S6 F 75 N.S6.01
Van-der-waals TM5 V 234 5x64 S6 F 75 N.S6.01
Hydrophobic ICL2 M 148 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 M 148 34x51 S8 L 129 N.S8.03
Hydrophobic ICL3 M 249 - S6 F 80 N.S6.06
Van-der-waals ICL3 M 249 - S6 F 80 N.S6.06
Hydrophobic TM5 A 238 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 A 238 5x68 S6 F 75 N.S6.01