Beta-arrestin-2 - GPR62 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPR62 68.8
Beta-arrestin-2 78.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 R 46 2x38 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 R 46 2x38 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 121 - S8 L 130 N.S8.03
Van-der-waals ICL2 L 121 - S8 L 130 N.S8.03
Hydrophobic TM6 L 230 6x24 S6 I 82 N.S6.07
Hydrophobic ICL2 L 121 - s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 L 121 - s8s9 A 140 N.s8s9.10
Polar ICL2 R 122 - S16 Y 250 C.S16.03
Hydrophobic ICL2 R 122 - S16 Y 250 C.S16.03
Van-der-waals ICL2 R 122 - S16 Y 250 C.S16.03
Polar TM6 R 233 6x27 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 233 6x27 s5s6 S 75 N.s5s6.11
Ionic TM2 R 46 2x38 s5s6 D 68 N.s5s6.04
Polar TM2 R 46 2x38 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 46 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 117 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 P 207 5x73 S6 D 79 N.S6.04
Van-der-waals TM5 P 207 5x73 S6 D 79 N.S6.04
Hydrophobic ICL3 L 227 - s9s10 L 155 N.s9s10.03
Polar TM3 V 118 3x55 S5 Y 64 N.S5.12
Hydrophobic TM6 P 243 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 P 206 5x72 S6 K 78 N.S6.03
Hydrophobic ICL2 L 121 - S5 Y 64 N.S5.12
Hydrophobic ICL2 P 120 - S5 Y 64 N.S5.12
Van-der-waals ICL2 P 120 - S5 Y 64 N.S5.12
Hydrophobic TM5 Y 192 5x58 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 Y 192 5x58 s5s6 L 72 N.s5s6.08
Polar ICL3 S 225 - S6 T 84 N.S6.09
Polar TM5 R 205 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 R 205 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 R 205 5x71 S6 K 78 N.S6.03
Hydrophobic TM6 L 234 6x28 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 234 6x28 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 R 46 2x38 s5s6 L 69 N.s5s6.05
Van-der-waals TM2 R 46 2x38 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 L 224 - S7 F 118 N.S7.06
Hydrophobic TM5 P 207 5x73 S6 L 80 N.S6.05
Hydrophobic TM5 A 199 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 199 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 R 233 6x27 S6 R 77 N.S6.02
Hydrophobic ICL2 L 121 - S15 I 242 C.S15.14
Van-der-waals ICL2 L 121 - S15 I 242 C.S15.14
Polar TM3 V 118 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 V 118 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 V 118 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 117 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 117 3x54 S6 F 76 N.S6.01
Hydrophobic TM5 I 195 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 I 195 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 V 198 5x64 s15s16 F 245 C.s15s16.03
Ionic TM2 R 46 2x38 s8s9 D 136 N.s8s9.06
Van-der-waals TM2 R 46 2x38 s8s9 D 136 N.s8s9.06
Polar ICL2 P 120 - s5s6 R 66 N.s5s6.02
Polar ICL3 R 223 - s6h1 N 93 N.s6h1.06
Hydrophobic ICL3 R 223 - s6h1 N 93 N.s6h1.06
Van-der-waals ICL3 R 223 - s6h1 N 93 N.s6h1.06
Hydrophobic ICL3 L 224 - S6 F 81 N.S6.06
Hydrophobic TM5 A 199 5x65 S6 F 76 N.S6.01
Hydrophobic H8 P 296 8x49 s5s6 D 68 N.s5s6.04
Van-der-waals H8 P 296 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 I 195 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 195 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 L 116 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 116 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 L 121 - S16 Y 250 C.S16.03
Hydrophobic ICL2 L 121 - S16 Y 250 C.S16.03
Van-der-waals ICL2 L 121 - S16 Y 250 C.S16.03
Hydrophobic TM5 P 207 5x73 S6 K 78 N.S6.03
Van-der-waals TM5 P 207 5x73 S6 K 78 N.S6.03
Hydrophobic TM5 A 202 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 A 202 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 A 202 5x68 S6 F 76 N.S6.01
Polar ICL3 S 222 - s7s8 T 119 N.s7s8.01
Hydrophobic ICL3 L 224 - S6 A 83 N.S6.08
Van-der-waals ICL3 L 224 - S6 A 83 N.S6.08
Hydrophobic TM6 A 242 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 242 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 L 227 - S6 T 84 N.S6.09
Van-der-waals ICL3 L 227 - S6 T 84 N.S6.09
Van-der-waals ICL1 G 44 - s5s6 D 68 N.s5s6.04
Polar ICL3 I 226 - S6 I 82 N.S6.07
Hydrophobic ICL3 I 226 - S6 I 82 N.S6.07
Van-der-waals ICL3 I 226 - S6 I 82 N.S6.07
Ionic H8 R 295 8x48 s5s6 D 70 N.s5s6.06
Polar H8 R 295 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 R 295 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 R 295 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 L 121 - S9 C 141 N.S9.01
Van-der-waals ICL2 L 121 - S9 C 141 N.S9.01
Van-der-waals ICL3 L 224 - s7s8 T 119 N.s7s8.01
Hydrophobic TM6 L 234 6x28 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 L 234 6x28 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 P 120 - s5s6 G 65 N.s5s6.01
Hydrophobic TM3 R 113 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 113 3x50 s5s6 V 71 N.s5s6.07
Ionic TM5 R 205 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 R 205 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 R 205 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 R 205 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM6 A 239 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic H8 Q 294 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 V 198 5x64 S6 F 76 N.S6.01
Polar TM2 R 46 2x38 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 P 229 - S6 I 82 N.S6.07
Hydrophobic ICL3 L 227 - S6 I 82 N.S6.07
Hydrophobic TM3 I 117 3x54 s5s6 L 69 N.s5s6.05