Arrestin-C - GPR62 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR62 68.9
Arrestin-C 80.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 195 5x61 s5s6 L 69 N.s5s6.10
Polar TM3 L 116 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 L 116 3x53 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 L 116 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM5 P 206 5x72 s17s18 L 311 C.s17s18.40
Polar TM3 H 119 3x56 S5 Y 59 N.S5.12
Hydrophobic ICL3 S 222 - s7s8 V 117 N.s7s8.03
Van-der-waals ICL3 S 222 - s7s8 V 117 N.s7s8.03
Hydrophobic TM5 P 206 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 P 206 5x72 S6 K 73 N.S6.03
Hydrophobic TM5 R 201 5x67 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 A 199 5x65 S6 F 71 N.S6.01
Hydrophobic TM6 L 230 6x24 S6 D 74 N.S6.04
Van-der-waals TM6 L 230 6x24 S6 D 74 N.S6.04
Polar ICL3 L 227 - S6 L 75 N.S6.05
Hydrophobic ICL3 L 227 - S6 L 75 N.S6.05
Van-der-waals ICL3 L 227 - S6 L 75 N.S6.05
Ionic H8 R 303 8x56 s20c E 383 C.s20c.17
Polar H8 R 303 8x56 s20c E 383 C.s20c.17
Van-der-waals H8 R 303 8x56 s20c E 383 C.s20c.17
Polar ICL2 G 124 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 G 124 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 G 124 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 P 120 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 120 - s15s16 S 242 C.s15s16.04
Hydrophobic TM5 I 195 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 121 - S9 C 137 N.S9.01
Van-der-waals ICL2 L 121 - S9 C 137 N.S9.01
Hydrophobic H8 P 296 8x49 s5s6 D 63 N.s5s6.04
Van-der-waals H8 P 296 8x49 s5s6 D 63 N.s5s6.04
Polar TM3 V 118 3x55 S5 Y 59 N.S5.12
Van-der-waals TM3 V 118 3x55 S5 Y 59 N.S5.12
Ionic H8 R 298 8x51 s5s6 E 65 N.s5s6.06
Polar H8 R 298 8x51 s5s6 E 65 N.s5s6.06
Polar TM3 I 117 3x54 S5 Y 59 N.S5.12
Hydrophobic TM3 I 117 3x54 S5 Y 59 N.S5.12
Van-der-waals TM3 I 117 3x54 S5 Y 59 N.S5.12
Polar ICL2 R 122 - S16 Y 246 C.S16.03
Hydrophobic ICL2 R 122 - S16 Y 246 C.S16.03
Van-der-waals ICL2 R 122 - S16 Y 246 C.S16.03
Hydrophobic TM5 P 206 5x72 S6 L 75 N.S6.05
Polar ICL2 L 121 - S16 Y 246 C.S16.03
Hydrophobic ICL2 L 121 - S16 Y 246 C.S16.03
Van-der-waals ICL2 L 121 - S16 Y 246 C.S16.03
Hydrophobic TM6 A 239 6x33 s5s6 L 69 N.s5s6.10
Ionic TM2 R 46 2x38 s8s9 D 132 N.s8s9.06
Polar TM2 R 46 2x38 s8s9 D 132 N.s8s9.06
Hydrophobic TM2 R 46 2x38 s8s9 D 132 N.s8s9.06
Van-der-waals TM2 R 46 2x38 s8s9 D 132 N.s8s9.06
Hydrophobic TM2 R 46 2x38 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 R 46 2x38 s5s6 R 61 N.s5s6.02
Polar TM3 L 116 3x53 S5 Y 59 N.S5.12
Hydrophobic ICL3 L 227 - S6 V 77 N.S6.07
Van-der-waals ICL3 L 227 - S6 V 77 N.S6.07
Ionic TM2 R 46 2x38 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 L 121 - S15 V 238 C.S15.14
Van-der-waals ICL2 L 121 - S15 V 238 C.S15.14
Hydrophobic TM5 A 202 5x68 S6 F 71 N.S6.01
Polar ICL2 P 120 - S5 Y 59 N.S5.12
Hydrophobic ICL2 P 120 - S5 Y 59 N.S5.12
Van-der-waals ICL2 P 120 - S5 Y 59 N.S5.12
Hydrophobic ICL3 I 226 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 I 226 - s17s18 L 311 C.s17s18.40
Hydrophobic TM2 R 46 2x38 s8s9 K 135 N.s8s9.09
Van-der-waals TM2 R 46 2x38 s8s9 K 135 N.s8s9.09
Hydrophobic TM5 P 206 5x72 S6 D 74 N.S6.04
Van-der-waals TM5 P 206 5x72 S6 D 74 N.S6.04
Hydrophobic TM6 L 234 6x28 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 L 234 6x28 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 R 113 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 113 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 L 116 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 P 243 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 P 243 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 I 117 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 117 3x54 S6 F 71 N.S6.01
Hydrophobic ICL2 G 124 - s8s9 E 131 N.s8s9.05
Hydrophobic ICL3 L 227 - S6 Y 76 N.S6.06
Van-der-waals ICL3 L 227 - S6 Y 76 N.S6.06
Polar ICL2 P 120 - s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 P 120 - s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 P 120 - s8s9 K 135 N.s8s9.09
Hydrophobic TM6 L 234 6x28 s5s6 L 69 N.s5s6.10
Van-der-waals TM2 R 46 2x38 s8s9 G 134 N.s8s9.08
Polar ICL1 G 44 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 G 44 - s5s6 R 61 N.s5s6.02
Polar TM3 V 118 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 V 118 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 V 118 3x55 s15s16 S 242 C.s15s16.04
Polar ICL2 S 125 - s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 S 125 - s8s9 E 131 N.s8s9.05
Ionic ICL2 R 122 - S16 D 244 C.S16.01
Polar ICL2 R 122 - S16 D 244 C.S16.01
Hydrophobic ICL2 R 122 - S16 D 244 C.S16.01
Van-der-waals ICL2 R 122 - S16 D 244 C.S16.01
Polar TM2 R 46 2x38 s8s9 E 131 N.s8s9.05
Ionic H8 R 295 8x48 s5s6 E 65 N.s5s6.06
Polar H8 R 295 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 R 295 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 295 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 L 230 6x24 S6 V 77 N.S6.07
Van-der-waals TM6 L 230 6x24 S6 V 77 N.S6.07
Polar TM5 L 204 5x70 S6 K 73 N.S6.03
Ionic TM3 H 119 3x56 S16 D 244 C.S16.01
Polar TM3 H 119 3x56 S16 D 244 C.S16.01
Hydrophobic TM3 H 119 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 H 119 3x56 S16 D 244 C.S16.01
Hydrophobic ICL2 P 123 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 P 123 - s8s9 D 132 N.s8s9.06
Hydrophobic TM3 I 117 3x54 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 Y 192 5x58 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 Y 192 5x58 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 V 198 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 205 5x71 S6 K 73 N.S6.03
Hydrophobic ICL2 L 121 - S8 L 126 N.S8.03
Van-der-waals ICL2 L 121 - S8 L 126 N.S8.03
Hydrophobic TM5 A 199 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 A 199 5x65 s5s6 L 69 N.s5s6.10
Ionic TM6 R 231 6x25 s9s10 E 152 N.s9s10.07
Polar TM6 R 231 6x25 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 R 231 6x25 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 R 231 6x25 s9s10 E 152 N.s9s10.07
Polar TM3 H 119 3x56 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 R 122 - s8s9 D 132 N.s8s9.06
Hydrophobic TM5 V 198 5x64 S6 F 71 N.S6.01
Polar ICL3 S 222 - s7s8 T 118 N.s7s8.04
Hydrophobic ICL3 S 222 - s7s8 T 118 N.s7s8.04
Van-der-waals ICL3 S 222 - s7s8 T 118 N.s7s8.04
Polar ICL3 S 222 - s7s8 N 119 N.s7s8.05
Van-der-waals ICL3 S 222 - s7s8 N 119 N.s7s8.05
Polar H8 R 306 8x59 s20c E 386 C.s20c.20
Van-der-waals H8 R 306 8x59 s20c E 386 C.s20c.20
Polar TM5 A 202 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 A 202 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 A 202 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 I 117 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 A 242 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 242 6x36 s5s6 I 67 N.s5s6.08