Beta-arrestin-1 - GPR63 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPR63 70.0
Beta-arrestin-1 82.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic C-term R 402 - S1 K 11 N.S1.04
Van-der-waals C-term R 402 - S1 K 11 N.S1.04
Hydrophobic C-term P 406 - S20 D 390 C.S20.05
Hydrophobic ICL3 F 300 - S6 L 79 N.S6.05
Van-der-waals ICL3 F 300 - S6 L 79 N.S6.05
Hydrophobic TM3 I 182 3x53 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 182 3x53 s5s6 L 73 N.s5s6.10
Hydrophobic C-term P 406 - S20 E 389 C.S20.04
Van-der-waals C-term P 406 - S20 E 389 C.S20.04
Polar TM2 N 117 2x40 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 N 117 2x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 N 117 2x40 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 183 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 183 3x54 s5s6 L 73 N.s5s6.10
Polar TM3 R 179 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 179 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 M 302 - s15s16 L 243 C.s15s16.02
Polar C-term T 400 - s20c G 409 C.s20c.19
Hydrophobic TM6 K 309 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 182 3x53 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 I 182 3x53 s15s16 F 244 C.s15s16.03
Hydrophobic TM4 N 191 4x38 s8s9 T 136 N.s8s9.07
Hydrophobic C-term Y 410 - S20 D 390 C.S20.05
Polar C-term Y 410 - S20 F 388 C.S20.03
Hydrophobic C-term Y 410 - S20 F 388 C.S20.03
Van-der-waals C-term Y 410 - S20 F 388 C.S20.03
Hydrophobic TM6 T 315 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 315 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 175 3x46 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 312 6x33 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 A 312 6x33 s5s6 G 72 N.s5s6.09
Polar TM2 S 114 2x37 s5s6 L 68 N.s5s6.05
Hydrophobic TM2 S 114 2x37 s5s6 L 68 N.s5s6.05
Ionic H8 K 376 8x48 s20c E 405 C.s20c.15
Polar H8 K 376 8x48 s20c E 405 C.s20c.15
Van-der-waals H8 K 376 8x48 s20c E 405 C.s20c.15
Hydrophobic ICL3 M 302 - s17s18 I 314 C.s17s18.40
Ionic TM6 D 305 6x26 S6 R 76 N.S6.02
Polar TM6 D 305 6x26 S6 R 76 N.S6.02
Hydrophobic TM6 D 305 6x26 S6 R 76 N.S6.02
Van-der-waals TM6 D 305 6x26 S6 R 76 N.S6.02
Hydrophobic TM6 I 304 6x25 S6 K 77 N.S6.03
Polar C-term R 402 - s20c S 412 C.s20c.22
Hydrophobic C-term R 402 - s20c S 412 C.s20c.22
Van-der-waals C-term R 402 - s20c S 412 C.s20c.22
Ionic ICL2 D 188 - s8s9 K 138 N.s8s9.09
Polar ICL2 D 188 - s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 D 188 - s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 D 188 - s8s9 K 138 N.s8s9.09
Hydrophobic C-term P 406 - s20c A 392 C.s20c.02
Van-der-waals C-term P 406 - s20c A 392 C.s20c.02
Hydrophobic TM6 A 312 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 312 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic H8 I 375 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 I 375 8x47 s5s6 V 70 N.s5s6.07
Polar C-term C 412 - H1 K 107 N.H1.09
Hydrophobic C-term C 412 - H1 K 107 N.H1.09
Van-der-waals C-term C 412 - H1 K 107 N.H1.09
Hydrophobic C-term V 409 - S20 V 387 C.S20.02
Van-der-waals C-term V 409 - S20 V 387 C.S20.02
Polar C-term R 402 - s20c T 410 C.s20c.20
Hydrophobic C-term R 402 - s20c T 410 C.s20c.20
Van-der-waals C-term R 402 - s20c T 410 C.s20c.20
Hydrophobic TM3 R 179 3x50 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 R 179 3x50 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 I 304 6x25 S6 F 75 N.S6.01
Van-der-waals TM6 I 304 6x25 S6 F 75 N.S6.01
Hydrophobic C-term Y 410 - S20 V 387 C.S20.02
Polar C-term R 402 - S1 A 12 N.S1.05
Hydrophobic C-term R 402 - S1 A 12 N.S1.05
Van-der-waals C-term R 402 - S1 A 12 N.S1.05
Ionic C-term R 402 - S20 D 390 C.S20.05
Polar C-term R 402 - s20c G 411 C.s20c.21
Hydrophobic C-term R 402 - s20c G 411 C.s20c.21
Van-der-waals C-term R 402 - s20c G 411 C.s20c.21
Hydrophobic ICL1 A 111 12x49 s5s6 L 68 N.s5s6.05
Van-der-waals ICL1 A 111 12x49 s5s6 L 68 N.s5s6.05
Polar TM4 N 191 4x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 N 191 4x38 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 I 316 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 R 186 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 R 186 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 D 188 - s15s16 N 245 C.s15s16.04
Ionic H8 K 377 8x49 s5s6 D 67 N.s5s6.04
Polar H8 K 377 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic H8 K 377 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 K 377 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic ICL3 M 302 - S6 L 79 N.S6.05
Van-der-waals ICL3 M 302 - S6 L 79 N.S6.05
Hydrophobic TM6 I 304 6x25 S6 R 76 N.S6.02
Van-der-waals TM6 I 304 6x25 S6 R 76 N.S6.02
Hydrophobic C-term I 404 - s20c A 392 C.s20c.02
Van-der-waals C-term I 404 - s20c A 392 C.s20c.02
Hydrophobic TM6 S 303 6x24 S6 K 77 N.S6.03
Van-der-waals TM6 S 303 6x24 S6 K 77 N.S6.03
Polar TM2 N 117 2x40 s5s6 L 68 N.s5s6.05
Van-der-waals TM2 N 117 2x40 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 A 312 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM2 I 116 2x39 s5s6 L 71 N.s5s6.08
Hydrophobic H8 K 377 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 L 120 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 L 120 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 I 116 2x39 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 I 116 2x39 s5s6 D 69 N.s5s6.06
Ionic TM3 R 179 3x50 s5s6 D 69 N.s5s6.06
Polar TM3 R 179 3x50 s5s6 D 69 N.s5s6.06
Van-der-waals TM3 R 179 3x50 s5s6 D 69 N.s5s6.06
Aromatic C-term Y 410 - S1 K 10 N.S1.03
Hydrophobic C-term Y 410 - S1 K 10 N.S1.03
Polar ICL2 D 188 - S5 Y 63 N.S5.12
Hydrophobic ICL2 D 188 - S5 Y 63 N.S5.12
Van-der-waals ICL2 D 188 - S5 Y 63 N.S5.12
Hydrophobic ICL3 M 302 - S6 K 77 N.S6.03
Van-der-waals ICL3 M 302 - S6 K 77 N.S6.03
Hydrophobic TM6 K 309 6x30 S6 F 75 N.S6.01
Van-der-waals TM6 K 309 6x30 S6 F 75 N.S6.01
Hydrophobic TM6 K 309 6x30 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 K 309 6x30 s5s6 T 74 N.s5s6.11
Hydrophobic ICL3 F 300 - S6 F 80 N.S6.06
Ionic H8 K 377 8x49 s20c E 405 C.s20c.15
Polar H8 K 377 8x49 s20c E 405 C.s20c.15
Hydrophobic H8 K 377 8x49 s20c E 405 C.s20c.15
Van-der-waals H8 K 377 8x49 s20c E 405 C.s20c.15
Hydrophobic TM2 N 117 2x40 s5s6 D 69 N.s5s6.06
Hydrophobic C-term C 412 - S20 F 388 C.S20.03
Van-der-waals C-term C 412 - S20 F 388 C.S20.03
Hydrophobic C-term P 406 - s20c Q 394 C.s20c.04
Hydrophobic C-term P 406 - s20c R 393 C.s20c.03
Van-der-waals C-term P 406 - s20c R 393 C.s20c.03
Hydrophobic TM4 R 194 4x41 s8s9 T 136 N.s8s9.07
Van-der-waals ICL3 M 302 - S6 D 78 N.S6.04
Hydrophobic TM6 F 308 6x29 s5s6 E 66 N.s5s6.03
Van-der-waals TM6 F 308 6x29 s5s6 E 66 N.s5s6.03
Hydrophobic C-term I 404 - S20 D 390 C.S20.05
Van-der-waals C-term I 404 - S20 D 390 C.S20.05
Ionic H8 D 384 8x56 s20c K 403 C.s20c.13
Polar H8 D 384 8x56 s20c K 403 C.s20c.13
Van-der-waals H8 D 384 8x56 s20c K 403 C.s20c.13
Polar C-term R 405 - S20 D 390 C.S20.05
Hydrophobic C-term R 405 - S20 D 390 C.S20.05
Van-der-waals C-term R 405 - S20 D 390 C.S20.05
Van-der-waals TM6 F 308 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM2 S 114 2x37 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 L 120 2x43 s5s6 L 71 N.s5s6.08
Polar TM6 S 303 6x24 S6 D 78 N.S6.04
Hydrophobic TM6 S 303 6x24 S6 D 78 N.S6.04
Van-der-waals TM6 S 303 6x24 S6 D 78 N.S6.04