Arrestin-C - GPR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR6 69.5
Arrestin-C 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 170 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 L 170 3x54 S6 F 71 N.S6.01
Hydrophobic TM2 M 107 2x39 s5s6 L 64 N.s5s6.05
Van-der-waals TM2 M 107 2x39 s5s6 L 64 N.s5s6.05
Polar ICL2 Y 177 34x54 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 Y 177 34x54 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 Y 177 34x54 s5s6 D 63 N.s5s6.04
Hydrophobic C-term R 355 - s20c V 380 C.s20c.13
Van-der-waals C-term R 355 - s20c V 380 C.s20c.13
Hydrophobic TM6 V 284 6x40 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 V 284 6x40 s5s6 I 67 N.s5s6.08
Polar C-term R 355 - s20c A 379 C.s20c.12
Hydrophobic C-term R 355 - s20c A 379 C.s20c.12
Van-der-waals C-term R 355 - s20c A 379 C.s20c.12
Ionic TM6 H 270 6x26 S6 D 74 N.S6.04
Polar TM6 H 270 6x26 S6 D 74 N.S6.04
Hydrophobic TM6 H 270 6x26 S6 D 74 N.S6.04
Van-der-waals TM6 H 270 6x26 S6 D 74 N.S6.04
Polar ICL2 L 174 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 L 174 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 174 34x51 S16 Y 246 C.S16.03
Hydrophobic TM5 I 259 5x72 s17s18 L 311 C.s17s18.40
Hydrophobic TM5 I 259 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 I 259 5x72 S6 K 73 N.S6.03
Hydrophobic TM3 I 162 3x46 s5s6 I 67 N.s5s6.08
Polar ICL2 R 180 34x57 s8s9 E 131 N.s8s9.05
Hydrophobic TM5 V 252 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 Q 258 5x71 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 Q 258 5x71 s17s18 L 311 C.s17s18.40
Polar TM5 Q 258 5x71 S6 K 73 N.S6.03
Polar ICL2 T 175 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL2 T 175 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 T 175 34x52 S16 Y 246 C.S16.03
Hydrophobic TM3 L 170 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 L 281 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 L 266 6x22 S6 Y 76 N.S6.06
Van-der-waals TM6 L 266 6x22 S6 Y 76 N.S6.06
Polar C-term E 361 - S10 R 162 N.S10.03
Hydrophobic C-term E 361 - S10 R 162 N.S10.03
Van-der-waals C-term E 361 - S10 R 162 N.S10.03
Hydrophobic ICL2 Y 177 34x54 s5s6 R 61 N.s5s6.02
Polar ICL2 Y 177 34x54 s5s6 R 61 N.s5s6.02
Aromatic ICL2 Y 177 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Y 177 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM2 P 106 2x38 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 P 106 2x38 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 S 169 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 S 169 3x53 s5s6 L 64 N.s5s6.05
Polar TM3 L 170 3x54 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 N 172 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 N 172 3x56 S16 D 244 C.S16.01
Hydrophobic TM5 V 252 5x65 S6 F 71 N.S6.01
Polar C-term S 360 - S10 R 162 N.S10.03
Hydrophobic TM6 L 266 6x22 S6 L 75 N.S6.05
Van-der-waals TM6 L 266 6x22 S6 L 75 N.S6.05
Polar TM5 H 255 5x68 s15s16 Y 241 C.s15s16.03
Aromatic TM5 H 255 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 255 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 255 5x68 s15s16 Y 241 C.s15s16.03
Polar TM5 Q 258 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 Q 258 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 Q 258 5x71 s17s18 E 310 C.s17s18.39
Polar C-term S 360 - s20c E 373 C.s20c.06
Polar TM5 H 255 5x68 S6 K 73 N.S6.03
Hydrophobic TM5 H 255 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 H 255 5x68 S6 K 73 N.S6.03
Hydrophobic TM6 L 266 6x22 S6 V 77 N.S6.07
Van-der-waals TM6 L 266 6x22 S6 V 77 N.S6.07
Hydrophobic TM6 H 270 6x26 S6 K 73 N.S6.03
Hydrophobic ICL2 Y 177 34x54 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 Y 177 34x54 s8s9 E 131 N.s8s9.05
Hydrophobic TM6 G 277 6x33 s5s6 L 69 N.s5s6.10
Polar ICL2 Y 177 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 Y 177 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 L 174 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 L 174 34x51 S9 C 137 N.S9.01
Hydrophobic TM2 M 107 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 M 107 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 L 170 3x54 s15s16 Y 241 C.s15s16.03
Van-der-waals TM3 L 170 3x54 s15s16 Y 241 C.s15s16.03
Polar ICL2 S 178 34x55 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 S 178 34x55 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 S 178 34x55 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 T 175 34x52 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 T 175 34x52 s8s9 D 132 N.s8s9.06
Polar TM3 Y 171 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 Y 171 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 Y 171 3x55 s15s16 S 242 C.s15s16.04
Polar C-term P 359 - s17s18 K 289 C.s17s18.18
Van-der-waals C-term P 359 - s17s18 K 289 C.s17s18.18
Hydrophobic ICL2 A 173 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 A 173 34x50 s15s16 S 242 C.s15s16.04
Ionic C-term R 355 - s20c E 383 C.s20c.17
Polar C-term R 355 - s20c E 383 C.s20c.17
Hydrophobic C-term R 355 - s20c E 383 C.s20c.17
Van-der-waals C-term R 355 - s20c E 383 C.s20c.17
Polar TM3 R 166 3x50 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 R 166 3x50 s5s6 D 63 N.s5s6.04
Polar C-term V 362 - S10 R 162 N.S10.03
Hydrophobic C-term V 362 - S10 R 162 N.S10.03
Van-der-waals C-term V 362 - S10 R 162 N.S10.03
Hydrophobic TM3 R 166 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 166 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 V 251 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 V 251 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 T 280 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 280 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM7 Y 329 7x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 Y 329 7x53 s5s6 V 66 N.s5s6.07
Hydrophobic C-term P 359 - s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 Y 177 34x54 s8s9 G 134 N.s8s9.08
Polar C-term V 362 - S5 R 58 N.S5.11
Van-der-waals C-term V 362 - S5 R 58 N.S5.11
Hydrophobic TM6 G 277 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 L 174 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 L 174 34x51 S8 L 126 N.S8.03
Hydrophobic TM6 T 280 6x36 s5s6 G 68 N.s5s6.09
Polar ICL2 S 178 34x55 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 S 178 34x55 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 S 178 34x55 s8s9 E 131 N.s8s9.05
Ionic ICL2 R 179 34x56 s8s9 E 131 N.s8s9.05
Polar ICL2 R 179 34x56 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 R 179 34x56 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 R 179 34x56 s8s9 E 131 N.s8s9.05
Polar H8 Q 334 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 Q 334 8x48 s5s6 E 65 N.s5s6.06
Polar ICL2 Y 176 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 Y 176 34x53 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Y 176 34x53 s5s6 R 61 N.s5s6.02
Polar ICL2 Y 177 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 Y 177 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 Y 177 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic TM6 L 281 6x37 s5s6 L 69 N.s5s6.10
Hydrophobic TM7 Y 329 7x53 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 Y 329 7x53 s5s6 I 67 N.s5s6.08
Polar TM3 L 170 3x54 S5 Y 59 N.S5.12
Hydrophobic TM3 L 170 3x54 S5 Y 59 N.S5.12
Van-der-waals TM3 L 170 3x54 S5 Y 59 N.S5.12
Polar ICL2 Y 176 34x53 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 L 174 34x51 S16 D 244 C.S16.01
Polar ICL2 A 173 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 A 173 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 A 173 34x50 S5 Y 59 N.S5.12
Hydrophobic TM6 H 270 6x26 S6 V 77 N.S6.07
Polar TM3 Y 171 3x55 S5 Y 59 N.S5.12
Hydrophobic H8 N 333 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 N 333 8x47 s5s6 V 66 N.s5s6.07
Polar C-term S 360 - s17s18 K 291 C.s17s18.20
Hydrophobic C-term S 360 - s17s18 K 291 C.s17s18.20
Van-der-waals C-term S 360 - s17s18 K 291 C.s17s18.20
Hydrophobic TM2 M 107 2x39 s5s6 V 66 N.s5s6.07
Polar TM3 S 169 3x53 S5 Y 59 N.S5.12
Hydrophobic TM3 S 169 3x53 S5 Y 59 N.S5.12
Van-der-waals TM3 S 169 3x53 S5 Y 59 N.S5.12
Hydrophobic TM3 R 166 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 166 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 174 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 174 34x51 S15 V 238 C.S15.14
Polar TM3 R 166 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 R 166 3x50 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 R 166 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 I 248 5x61 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 Q 262 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 Q 262 - s17s18 L 311 C.s17s18.40
Hydrophobic TM5 H 255 5x68 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 H 255 5x68 s15s16 L 240 C.s15s16.02