ArrestinDb

S-arrestin - GPR6 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
GPR6	70.1
S-arrestin	80.4

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 18.8

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	TM5	H	255	5x68	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL2	Y	176	34x53	s8s9	K	145	N.s8s9.09
Hydrophobic	ICL2	S	178	34x55	s8s9	D	142	N.s8s9.06
Hydrophobic	TM6	L	266	6x22	S6	D	86	N.S6.04
Hydrophobic	H8	N	333	8x47	s5s6	V	78	N.s5s6.07
Hydrophobic	TM5	I	259	5x72	S6	R	85	N.S6.03
Hydrophobic	ICL2	L	174	34x51	S8	L	136	N.S8.03
Hydrophobic	ICL2	Y	177	34x54	s8s9	D	142	N.s8s9.06
Hydrophobic	TM5	V	252	5x65	S6	F	83	N.S6.01
Hydrophobic	TM7	Y	329	7x53	s5s6	I	79	N.s5s6.08
Hydrophobic	C-term	P	359	-	S10	L	177	N.S10.05
Hydrophobic	TM3	L	170	3x54	S6	F	83	N.S6.01
Hydrophobic	ICL3	Q	262	-	s17s18	V	324	C.s17s18.40
Hydrophobic	TM5	Q	258	5x71	S6	R	85	N.S6.03
Hydrophobic	TM5	I	259	5x72	S6	L	87	N.S6.05
Hydrophobic	C-term	S	360	-	s17s18	K	302	C.s17s18.18
Hydrophobic	TM3	R	166	3x50	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL2	L	174	34x51	S9	C	147	N.S9.01
Hydrophobic	TM5	Y	245	5x58	s5s6	I	79	N.s5s6.08
Hydrophobic	TM3	R	166	3x50	s5s6	V	78	N.s5s6.07
Hydrophobic	TM6	H	270	6x26	S6	R	84	N.S6.02
Hydrophobic	H8	E	335	8x49	s5s6	D	75	N.s5s6.04
Hydrophobic	C-term	S	360	-	S10	L	177	N.S10.05
Hydrophobic	C-term	V	362	-	s1s2	R	22	N.s1s2.02
Hydrophobic	TM3	R	166	3x50	s5s6	I	76	N.s5s6.05
Hydrophobic	C-term	P	359	-	s5s6	E	74	N.s5s6.03
Hydrophobic	ICL2	A	173	34x50	s15s16	S	255	C.s15s16.04
Hydrophobic	TM2	M	107	2x39	s5s6	D	75	N.s5s6.04
Hydrophobic	ICL2	T	175	34x52	s8s9	K	145	N.s8s9.09
Hydrophobic	TM6	P	269	6x25	s9s10	A	163	N.s9s10.05
Hydrophobic	TM2	M	107	2x39	s5s6	I	76	N.s5s6.05
Hydrophobic	TM6	L	266	6x22	S6	L	87	N.S6.05
Hydrophobic	ICL2	T	175	34x52	S16	Y	259	C.S16.03
Hydrophobic	TM6	L	281	6x37	s5s6	L	81	N.s5s6.10
Hydrophobic	TM6	A	267	6x23	S6	F	89	N.S6.07
Hydrophobic	TM3	L	170	3x54	s15s16	Y	254	C.s15s16.03
Hydrophobic	TM5	H	255	5x68	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL2	L	174	34x51	S15	V	251	C.S15.14
Hydrophobic	TM6	V	284	6x40	s5s6	I	79	N.s5s6.08
Hydrophobic	TM7	Y	329	7x53	s5s6	V	78	N.s5s6.07
Hydrophobic	TM3	S	169	3x53	s5s6	I	76	N.s5s6.05
Hydrophobic	TM3	Y	171	3x55	s15s16	S	255	C.s15s16.04
Hydrophobic	TM6	L	281	6x37	s5s6	I	79	N.s5s6.08
Hydrophobic	TM5	V	252	5x65	s5s6	L	81	N.s5s6.10
Hydrophobic	TM2	M	107	2x39	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL2	Y	177	34x54	s8s9	K	145	N.s8s9.09
Hydrophobic	TM5	I	248	5x61	s5s6	L	81	N.s5s6.10
Hydrophobic	TM6	H	270	6x26	S6	D	86	N.S6.04
Hydrophobic	TM5	V	251	5x64	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL2	L	174	34x51	S16	D	257	C.S16.01
Hydrophobic	ICL2	L	174	34x51	S16	Y	259	C.S16.03
Hydrophobic	TM5	Q	258	5x71	s17s18	T	323	C.s17s18.39
Hydrophobic	ICL2	Y	177	34x54	s5s6	Q	73	N.s5s6.02
Hydrophobic	TM6	T	280	6x36	s5s6	I	79	N.s5s6.08
Hydrophobic	TM6	L	266	6x22	S6	F	89	N.S6.07
Hydrophobic	TM5	H	255	5x68	S6	R	85	N.S6.03
Hydrophobic	TM6	G	277	6x33	s5s6	G	80	N.s5s6.09
Hydrophobic	ICL2	L	174	34x51	s8s9	K	145	N.s8s9.09
Hydrophobic	TM5	H	255	5x68	s15s16	L	253	C.s15s16.02
Hydrophobic	TM6	L	266	6x22	S6	Y	88	N.S6.06
Hydrophobic	TM3	S	169	3x53	S5	Y	71	N.S5.12
Hydrophobic	ICL2	A	173	34x50	S5	Y	71	N.S5.12
Hydrophobic	TM6	H	270	6x26	S6	R	85	N.S6.03
Hydrophobic	TM5	I	259	5x72	S6	D	86	N.S6.04
Hydrophobic	TM6	G	277	6x33	s5s6	L	81	N.s5s6.10
Ionic	C-term	R	355	-	s20c	E	392	C.s20c.11
Ionic	C-term	E	361	-	s17s18	K	304	C.s17s18.20
Ionic	TM6	H	270	6x26	S6	D	86	N.S6.04
Ionic	TM6	K	276	6x32	s9s10	D	166	N.s9s10.08
Polar	ICL2	S	178	34x55	s8s9	D	142	N.s8s9.06
Polar	C-term	R	355	-	s20c	E	392	C.s20c.11
Polar	TM5	Q	258	5x71	S6	R	85	N.S6.03
Polar	C-term	S	360	-	s17s18	K	302	C.s17s18.18
Polar	C-term	E	361	-	s17s18	K	304	C.s17s18.20
Polar	TM3	R	166	3x50	s5s6	I	76	N.s5s6.05
Polar	ICL2	A	173	34x50	s15s16	S	255	C.s15s16.04
Polar	ICL2	T	175	34x52	s8s9	K	145	N.s8s9.09
Polar	ICL3	Q	262	-	s7s8	Y	129	N.s7s8.05
Polar	ICL2	T	175	34x52	S16	Y	259	C.S16.03
Polar	TM3	Y	171	3x55	s15s16	S	255	C.s15s16.04
Polar	ICL2	A	173	34x50	S16	D	257	C.S16.01
Polar	TM6	H	270	6x26	S6	D	86	N.S6.04
Polar	ICL2	L	174	34x51	S16	D	257	C.S16.01
Polar	C-term	V	362	-	S1	K	19	N.S1.04
Polar	ICL2	L	174	34x51	S16	Y	259	C.S16.03
Polar	TM5	Q	258	5x71	s17s18	T	323	C.s17s18.39
Polar	ICL2	Y	177	34x54	s5s6	Q	73	N.s5s6.02
Polar	TM6	T	280	6x36	s5s6	I	79	N.s5s6.08
Polar	TM5	H	255	5x68	S6	R	85	N.S6.03
Polar	H8	N	333	8x47	s5s6	D	75	N.s5s6.04
Polar	ICL2	L	174	34x51	s8s9	K	145	N.s8s9.09
Polar	TM5	H	255	5x68	s15s16	L	253	C.s15s16.02
Polar	TM3	S	169	3x53	S5	Y	71	N.S5.12
Polar	ICL2	A	173	34x50	S5	Y	71	N.S5.12
Polar	TM6	K	276	6x32	s9s10	D	166	N.s9s10.08
Van-der-waals	TM6	L	266	6x22	S6	D	86	N.S6.04
Van-der-waals	H8	N	333	8x47	s5s6	V	78	N.s5s6.07
Van-der-waals	TM5	I	259	5x72	S6	R	85	N.S6.03
Van-der-waals	ICL2	L	174	34x51	S8	L	136	N.S8.03
Van-der-waals	ICL2	Y	177	34x54	s8s9	D	142	N.s8s9.06
Van-der-waals	C-term	R	355	-	s20c	E	392	C.s20c.11
Van-der-waals	TM3	L	170	3x54	S6	F	83	N.S6.01
Van-der-waals	ICL3	Q	262	-	s17s18	V	324	C.s17s18.40
Van-der-waals	TM5	Q	258	5x71	S6	R	85	N.S6.03
Van-der-waals	C-term	S	360	-	s17s18	K	302	C.s17s18.18
Van-der-waals	TM3	R	166	3x50	s5s6	I	79	N.s5s6.08
Van-der-waals	ICL2	L	174	34x51	S9	C	147	N.S9.01
Van-der-waals	TM3	R	166	3x50	s5s6	V	78	N.s5s6.07
Van-der-waals	TM6	H	270	6x26	S6	R	84	N.S6.02
Van-der-waals	C-term	E	361	-	s17s18	K	304	C.s17s18.20
Van-der-waals	C-term	V	362	-	s1s2	R	22	N.s1s2.02
Van-der-waals	TM3	R	166	3x50	s5s6	I	76	N.s5s6.05
Van-der-waals	C-term	P	359	-	s5s6	E	74	N.s5s6.03
Van-der-waals	ICL2	A	173	34x50	s15s16	S	255	C.s15s16.04
Van-der-waals	TM2	M	107	2x39	s5s6	D	75	N.s5s6.04
Van-der-waals	ICL2	T	175	34x52	s8s9	K	145	N.s8s9.09
Van-der-waals	TM6	P	269	6x25	s9s10	A	163	N.s9s10.05
Van-der-waals	TM2	M	107	2x39	s5s6	I	76	N.s5s6.05
Van-der-waals	TM6	L	266	6x22	S6	L	87	N.S6.05
Van-der-waals	ICL2	T	175	34x52	S16	Y	259	C.S16.03
Van-der-waals	TM6	A	267	6x23	S6	F	89	N.S6.07
Van-der-waals	TM5	H	255	5x68	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL2	L	174	34x51	S15	V	251	C.S15.14
Van-der-waals	TM7	Y	329	7x53	s5s6	V	78	N.s5s6.07
Van-der-waals	TM3	S	169	3x53	s5s6	I	76	N.s5s6.05
Van-der-waals	TM3	Y	171	3x55	s15s16	S	255	C.s15s16.04
Van-der-waals	TM2	M	107	2x39	s5s6	V	78	N.s5s6.07
Van-der-waals	ICL2	Y	177	34x54	s8s9	K	145	N.s8s9.09
Van-der-waals	TM6	H	270	6x26	S6	D	86	N.S6.04
Van-der-waals	C-term	V	362	-	S1	K	19	N.S1.04
Van-der-waals	ICL2	S	178	34x55	s8s9	K	145	N.s8s9.09
Van-der-waals	ICL2	L	174	34x51	S16	Y	259	C.S16.03
Van-der-waals	TM5	Q	258	5x71	s17s18	T	323	C.s17s18.39
Van-der-waals	ICL2	Y	177	34x54	s5s6	Q	73	N.s5s6.02
Van-der-waals	TM6	T	280	6x36	s5s6	I	79	N.s5s6.08
Van-der-waals	TM6	L	266	6x22	S6	F	89	N.S6.07
Van-der-waals	TM5	H	255	5x68	S6	R	85	N.S6.03
Van-der-waals	ICL2	L	174	34x51	s8s9	K	145	N.s8s9.09
Van-der-waals	TM5	H	255	5x68	s15s16	L	253	C.s15s16.02
Van-der-waals	TM6	L	266	6x22	S6	Y	88	N.S6.06
Van-der-waals	TM3	S	169	3x53	S5	Y	71	N.S5.12
Van-der-waals	ICL2	A	173	34x50	S5	Y	71	N.S5.12
Van-der-waals	TM6	H	270	6x26	S6	R	85	N.S6.03
Van-der-waals	TM5	I	259	5x72	S6	D	86	N.S6.04
Van-der-waals	TM6	K	276	6x32	s9s10	D	166	N.s9s10.08
Van-der-waals	TM6	G	277	6x33	s5s6	L	81	N.s5s6.10

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Main reference

S-arrestin - GPR6 complex model Download Full