Beta-arrestin-1 - GPR75 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR75 58.8
Beta-arrestin-1 82.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL4 N 379 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL4 N 379 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL4 N 379 - s8s9 E 134 N.s8s9.05
Hydrophobic TM3 R 143 3x50 s5s6 L 71 N.s5s6.08
Polar TM6 N 310 6x24 S6 R 76 N.S6.02
Hydrophobic TM6 N 310 6x24 S6 R 76 N.S6.02
Van-der-waals TM6 N 310 6x24 S6 R 76 N.S6.02
Hydrophobic TM6 T 322 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 322 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 I 309 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 I 309 - s15s16 F 244 C.s15s16.03
Hydrophobic TM2 T 77 2x37 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 L 311 6x25 S6 F 75 N.S6.01
Van-der-waals TM6 L 311 6x25 S6 F 75 N.S6.01
Polar ICL1 R 73 12x48 S16 K 250 C.S16.04
Van-der-waals ICL1 R 73 12x48 S16 K 250 C.S16.04
Hydrophobic TM6 I 326 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 K 315 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 M 146 3x53 s15s16 N 245 C.s15s16.04
Polar ICL1 R 76 12x51 S16 Y 249 C.S16.03
Hydrophobic ICL1 R 76 12x51 S16 Y 249 C.S16.03
Van-der-waals ICL1 R 76 12x51 S16 Y 249 C.S16.03
Hydrophobic TM5 L 229 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 229 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 C 323 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 C 323 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 V 147 3x54 s5s6 L 73 N.s5s6.10
Polar TM6 S 312 6x26 s20c E 407 C.s20c.17
Van-der-waals TM6 S 312 6x26 s20c E 407 C.s20c.17
Hydrophobic TM6 D 316 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 D 316 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic ICL3 S 307 - S6 K 77 N.S6.03
Hydrophobic C-term Y 486 - s18s19 L 338 C.s18s19.09
Van-der-waals C-term Y 486 - s18s19 L 338 C.s18s19.09
Hydrophobic TM6 K 315 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 K 315 6x29 s5s6 T 74 N.s5s6.11
Polar TM6 S 312 6x26 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 S 312 6x26 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 S 312 6x26 s5s6 T 74 N.s5s6.11
Hydrophobic ICL1 F 72 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 F 72 - s8s9 E 134 N.s8s9.05
Ionic ICL1 K 74 12x49 s8s9 E 134 N.s8s9.05
Polar ICL1 K 74 12x49 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 A 319 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 319 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL1 F 72 - s8s9 P 133 N.s8s9.04
Hydrophobic TM7 R 378 7x55 s5s6 D 69 N.s5s6.06
Polar C-term Y 486 - s18s19 S 340 C.s18s19.11
Hydrophobic C-term Y 486 - s18s19 S 340 C.s18s19.11
Van-der-waals C-term Y 486 - s18s19 S 340 C.s18s19.11
Hydrophobic TM2 F 79 2x39 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 F 79 2x39 s5s6 D 69 N.s5s6.06
Polar TM6 N 310 6x24 S6 D 78 N.S6.04
Hydrophobic TM6 A 319 6x33 s5s6 L 71 N.s5s6.08
Ionic TM7 R 378 7x55 s8s9 D 135 N.s8s9.06
Polar TM7 R 378 7x55 s8s9 D 135 N.s8s9.06
Hydrophobic TM7 R 378 7x55 s8s9 D 135 N.s8s9.06
Van-der-waals TM7 R 378 7x55 s8s9 D 135 N.s8s9.06
Hydrophobic ICL3 V 241 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 V 241 - s9s10 E 155 N.s9s10.07
Hydrophobic TM3 M 146 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL1 R 76 12x51 S16 A 247 C.S16.01
Van-der-waals ICL1 R 76 12x51 S16 A 247 C.S16.01
Polar C-term Y 486 - s18s19 D 337 C.s18s19.08
Hydrophobic TM3 M 146 3x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 M 146 3x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 P 239 5x75 s9s10 E 155 N.s9s10.07
Van-der-waals TM5 P 239 5x75 s9s10 E 155 N.s9s10.07
Ionic ICL1 R 76 12x51 s8s9 D 135 N.s8s9.06
Polar ICL1 R 76 12x51 s8s9 D 135 N.s8s9.06
Van-der-waals ICL1 R 76 12x51 s8s9 D 135 N.s8s9.06
Polar ICL1 R 76 12x51 S16 Q 248 C.S16.02
Polar TM3 H 142 3x49 s15s16 N 245 C.s15s16.04
Polar ICL2 Q 151 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 Q 151 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 Q 151 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 I 309 - S6 F 75 N.S6.01
Van-der-waals ICL3 I 309 - S6 F 75 N.S6.01
Hydrophobic TM2 T 77 2x37 S16 A 247 C.S16.01
Hydrophobic TM3 M 146 3x53 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 M 146 3x53 s15s16 F 244 C.s15s16.03
Van-der-waals TM7 Y 376 7x53 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 Y 222 5x58 s5s6 L 71 N.s5s6.08
Ionic ICL1 R 76 12x51 s5s6 D 67 N.s5s6.04
Polar ICL1 R 76 12x51 s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 R 76 12x51 s5s6 D 67 N.s5s6.04
Hydrophobic ICL3 L 303 - S6 F 80 N.S6.06
Hydrophobic ICL3 L 305 - s17s18 I 314 C.s17s18.40
Van-der-waals ICL3 L 305 - s17s18 I 314 C.s17s18.40
Ionic TM3 R 143 3x50 s5s6 D 69 N.s5s6.06
Polar TM3 R 143 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 143 3x50 s5s6 D 69 N.s5s6.06
Van-der-waals TM3 R 143 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic TM7 R 378 7x55 s5s6 E 66 N.s5s6.03
Van-der-waals TM7 R 378 7x55 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 T 77 2x37 s15s16 N 245 C.s15s16.04
Polar ICL2 T 155 - s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 T 155 - s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 T 155 - s15s16 T 246 C.s15s16.05
Hydrophobic TM5 I 225 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic H8 A 381 8x48 s5s6 E 66 N.s5s6.03
Van-der-waals H8 A 381 8x48 s5s6 E 66 N.s5s6.03
Hydrophobic TM6 L 311 6x25 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 M 146 3x53 S6 F 75 N.S6.01
Ionic TM7 R 378 7x55 s5s6 D 67 N.s5s6.04
Polar TM7 R 378 7x55 s5s6 D 67 N.s5s6.04
Hydrophobic TM7 R 378 7x55 s5s6 D 67 N.s5s6.04
Van-der-waals TM7 R 378 7x55 s5s6 D 67 N.s5s6.04
Ionic H8 K 386 8x53 s8s9 E 134 N.s8s9.05
Polar H8 K 386 8x53 s8s9 E 134 N.s8s9.05
Van-der-waals H8 K 386 8x53 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 L 311 6x25 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 L 311 6x25 s5s6 T 74 N.s5s6.11
Hydrophobic C-term Y 486 - s18s19 A 339 C.s18s19.10
Hydrophobic ICL3 I 242 - s9s10 L 154 N.s9s10.03
Van-der-waals ICL3 I 309 - S6 R 76 N.S6.02