Beta-arrestin-2 - GPR75 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR75 60.1
Beta-arrestin-2 81.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM6 K 315 6x29 s5s6 D 70 N.s5s6.06
Hydrophobic TM7 I 375 7x52 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 I 375 7x52 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 143 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 143 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic C-term I 485 - s17s18 E 309 C.s17s18.34
Polar TM3 R 143 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 143 3x50 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 143 3x50 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 I 309 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 I 309 - s15s16 F 245 C.s15s16.03
Hydrophobic TM7 R 378 7x55 s5s6 V 71 N.s5s6.07
Polar TM6 S 312 6x26 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 L 311 6x25 s5s6 S 75 N.s5s6.11
Hydrophobic C-term Y 483 - s17s18 K 313 C.s17s18.38
Hydrophobic ICL3 L 303 - s7s8 N 123 N.s7s8.05
Van-der-waals ICL3 L 303 - s7s8 N 123 N.s7s8.05
Hydrophobic TM6 K 315 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 315 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 D 316 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic C-term Y 483 - S18 L 319 C.S18.02
Van-der-waals C-term Y 483 - S18 L 319 C.S18.02
Polar TM6 N 310 6x24 S6 D 79 N.S6.04
Van-der-waals TM6 N 310 6x24 S6 D 79 N.S6.04
Polar C-term C 446 - S16 C 252 C.S16.05
Hydrophobic C-term C 446 - S16 C 252 C.S16.05
Van-der-waals C-term C 446 - S16 C 252 C.S16.05
Ionic TM3 H 142 3x49 s5s6 D 68 N.s5s6.04
Polar TM3 H 142 3x49 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 H 142 3x49 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 H 142 3x49 s5s6 D 68 N.s5s6.04
Hydrophobic C-term V 442 - s17s18 E 284 C.s17s18.09
Polar ICL1 R 76 12x51 s8s9 P 134 N.s8s9.04
Hydrophobic ICL1 R 76 12x51 s8s9 P 134 N.s8s9.04
Van-der-waals ICL1 R 76 12x51 s8s9 P 134 N.s8s9.04
Polar C-term S 449 - S16 K 251 C.S16.04
Hydrophobic C-term S 449 - S16 K 251 C.S16.04
Van-der-waals C-term S 449 - S16 K 251 C.S16.04
Polar C-term E 480 - S18 R 323 C.S18.06
Hydrophobic TM6 K 315 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 V 147 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 Q 151 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Q 151 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 151 - s5s6 R 66 N.s5s6.02
Hydrophobic C-term P 448 - S16 Y 250 C.S16.03
Polar TM6 N 310 6x24 S6 R 77 N.S6.02
Hydrophobic TM6 N 310 6x24 S6 R 77 N.S6.02
Van-der-waals TM6 N 310 6x24 S6 R 77 N.S6.02
Hydrophobic TM5 L 229 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 229 5x65 s5s6 L 74 N.s5s6.10
Polar TM6 K 315 6x29 s20c Q 407 C.s20c.17
Hydrophobic TM6 K 315 6x29 s20c Q 407 C.s20c.17
Van-der-waals TM6 K 315 6x29 s20c Q 407 C.s20c.17
Polar C-term C 446 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term C 446 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term C 446 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term C 446 - S16 P 253 C.S16.06
Van-der-waals C-term C 446 - S16 P 253 C.S16.06
Hydrophobic C-term Y 486 - s10s11 K 178 C.s10s11.04
Van-der-waals C-term Y 486 - s10s11 K 178 C.s10s11.04
Hydrophobic TM3 M 146 3x53 S6 F 76 N.S6.01
Hydrophobic TM7 S 377 7x54 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 C 323 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 M 146 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 M 146 3x53 s5s6 R 66 N.s5s6.02
Polar ICL2 N 153 - s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 N 153 - s15s16 T 247 C.s15s16.05
Hydrophobic C-term C 446 - s17s18 G 287 C.s17s18.12
Hydrophobic ICL3 I 242 - S6 I 82 N.S6.07
Van-der-waals C-term S 484 - s17s18 I 306 C.s17s18.31
Hydrophobic C-term Y 486 - s10s11 A 175 C.s10s11.01
Polar C-term I 479 - S18 R 323 C.S18.06
Hydrophobic C-term I 479 - S18 R 323 C.S18.06
Polar C-term Y 483 - S15 D 241 C.S15.13
Van-der-waals C-term Y 483 - S15 D 241 C.S15.13
Hydrophobic TM5 I 225 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 Y 222 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 Y 376 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 376 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 V 147 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 147 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 L 311 6x25 S6 F 76 N.S6.01
Hydrophobic C-term D 443 - s17s18 E 284 C.s17s18.09
Van-der-waals C-term D 443 - s17s18 E 284 C.s17s18.09
Hydrophobic C-term Y 486 - S13 L 208 C.S13.01
Van-der-waals C-term Y 486 - S13 L 208 C.S13.01
Ionic H8 R 385 8x52 s20c D 403 C.s20c.13
Hydrophobic ICL2 Q 151 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 Q 151 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL1 A 71 - s8s9 P 134 N.s8s9.04
Van-der-waals ICL1 A 71 - s8s9 P 134 N.s8s9.04
Hydrophobic TM6 I 326 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 326 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 M 146 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 M 146 3x53 s5s6 D 68 N.s5s6.04
Ionic ICL1 K 74 12x49 s8s9 E 135 N.s8s9.05
Polar ICL1 K 74 12x49 s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 K 74 12x49 s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 K 74 12x49 s8s9 E 135 N.s8s9.05
Polar TM6 A 319 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 319 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 319 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic C-term P 448 - S16 Q 249 C.S16.02
Van-der-waals C-term P 448 - S16 Q 249 C.S16.02
Hydrophobic C-term Y 486 - s17s18 I 306 C.s17s18.31
Hydrophobic ICL3 L 303 - s7s8 L 124 N.s7s8.06
Hydrophobic TM5 P 239 5x75 s9s10 L 155 N.s9s10.03
Polar ICL1 R 76 12x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 R 76 12x51 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 R 76 12x51 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 R 143 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 R 76 12x51 s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 R 76 12x51 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 A 319 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 319 6x33 s5s6 L 74 N.s5s6.10
Polar C-term C 446 - S16 K 251 C.S16.04
Hydrophobic C-term C 446 - S16 K 251 C.S16.04
Van-der-waals C-term C 446 - S16 K 251 C.S16.04
Hydrophobic C-term S 484 - S19 V 343 C.S19.10
Van-der-waals C-term S 484 - S19 V 343 C.S19.10
Hydrophobic C-term Y 482 - S19 P 341 C.S19.08
Hydrophobic C-term Y 486 - s3s4 L 32 N.s3s4.02
Van-der-waals C-term Y 486 - s3s4 L 32 N.s3s4.02
Polar C-term Q 444 - S16 Q 256 C.S16.09
Hydrophobic C-term Y 483 - s17s18 V 307 C.s17s18.32
Hydrophobic TM2 F 79 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 F 79 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 T 322 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic C-term G 447 - s8s9 D 136 N.s8s9.06
Van-der-waals C-term G 447 - s8s9 D 136 N.s8s9.06
Hydrophobic C-term P 448 - s8s9 D 136 N.s8s9.06
Van-der-waals C-term P 448 - s8s9 D 136 N.s8s9.06
Hydrophobic ICL3 L 305 - s17s18 V 315 C.s17s18.40
Van-der-waals ICL3 L 305 - s17s18 V 315 C.s17s18.40
Ionic C-term D 443 - s17s18 R 286 C.s17s18.11
Ionic ICL1 R 76 12x51 s5s6 E 67 N.s5s6.03
Polar ICL1 R 76 12x51 s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 R 76 12x51 s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 R 76 12x51 s5s6 E 67 N.s5s6.03
Hydrophobic C-term Q 444 - s17s18 K 285 C.s17s18.10
Hydrophobic TM5 P 239 5x75 s9s10 E 156 N.s9s10.07
Hydrophobic ICL1 R 76 12x51 s8s9 D 136 N.s8s9.06
Van-der-waals ICL1 R 76 12x51 s8s9 D 136 N.s8s9.06
Hydrophobic C-term A 445 - s8s9 E 135 N.s8s9.05
Van-der-waals C-term A 445 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 Q 151 - S6 F 76 N.S6.01
Van-der-waals ICL2 Q 151 - S6 F 76 N.S6.01
Hydrophobic C-term F 441 - s17s18 E 284 C.s17s18.09
Polar C-term Y 486 - s10s11 P 176 C.s10s11.02
Van-der-waals C-term Y 486 - s10s11 P 176 C.s10s11.02
Polar C-term N 487 - s10s11 K 178 C.s10s11.04
Van-der-waals C-term N 487 - s10s11 K 178 C.s10s11.04
Hydrophobic TM3 R 143 3x50 s5s6 L 69 N.s5s6.05
Polar C-term S 449 - S16 Q 249 C.S16.02
Ionic TM7 R 378 7x55 s5s6 E 67 N.s5s6.03
Polar TM7 R 378 7x55 s5s6 E 67 N.s5s6.03
Hydrophobic TM7 R 378 7x55 s5s6 E 67 N.s5s6.03
Van-der-waals TM7 R 378 7x55 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 M 146 3x53 s5s6 L 69 N.s5s6.05
Polar TM6 K 315 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 K 315 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 K 315 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic C-term Y 483 - S18 S 321 C.S18.04
Hydrophobic TM5 K 237 5x73 s9s10 K 158 N.s9s10.09
Hydrophobic TM6 L 311 6x25 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 T 77 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 T 77 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic ICL3 I 309 - S6 F 76 N.S6.01
Van-der-waals ICL3 I 309 - S6 F 76 N.S6.01
Hydrophobic ICL3 L 305 - S6 L 80 N.S6.05
Hydrophobic ICL3 L 305 - S6 K 78 N.S6.03
Van-der-waals ICL3 L 305 - S6 K 78 N.S6.03