ArrestinDb

S-arrestin - GPR75 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
GPR75	57.4
S-arrestin	79.7

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.5

iPTM Score: 0.4

PAE mean: 20.9

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	ICL1	F	75	12x50	S16	Y	259	C.S16.03
Hydrophobic	ICL2	Q	151	-	s15s16	L	253	C.s15s16.02
Hydrophobic	C-term	S	511	-	S11	W	198	C.S11.05
Hydrophobic	TM6	N	310	6x24	S6	R	84	N.S6.02
Hydrophobic	C-term	H	518	-	s10s11	P	190	C.s10s11.07
Hydrophobic	ICL3	I	309	-	S6	R	84	N.S6.02
Hydrophobic	TM6	N	310	6x24	S6	D	86	N.S6.04
Hydrophobic	ICL1	K	74	12x49	S16	K	261	C.S16.05
Hydrophobic	TM6	T	313	6x27	s9s10	D	166	N.s9s10.08
Hydrophobic	TM5	K	237	5x73	s9s10	E	164	N.s9s10.06
Hydrophobic	TM6	T	322	6x36	s5s6	V	78	N.s5s6.07
Hydrophobic	TM3	R	143	3x50	s5s6	I	79	N.s5s6.08
Hydrophobic	C-term	I	513	-	S11	A	196	C.S11.03
Hydrophobic	ICL1	F	72	-	s8s9	Q	141	N.s8s9.05
Hydrophobic	C-term	T	519	-	S19	P	356	C.S19.08
Hydrophobic	TM7	R	378	7x55	s5s6	V	78	N.s5s6.07
Hydrophobic	C-term	Y	517	-	S19	V	355	C.S19.07
Hydrophobic	TM2	T	77	2x37	S16	D	257	C.S16.01
Hydrophobic	TM6	L	311	6x25	S6	F	83	N.S6.01
Hydrophobic	ICL1	F	72	-	s8s9	K	145	N.s8s9.09
Hydrophobic	TM7	S	377	7x54	s5s6	V	78	N.s5s6.07
Hydrophobic	C-term	Y	517	-	S19	E	354	C.S19.06
Hydrophobic	TM5	L	229	5x65	s5s6	L	81	N.s5s6.10
Hydrophobic	C-term	A	509	-	S11	Q	199	C.S11.06
Hydrophobic	C-term	L	523	-	s17s18	T	314	C.s17s18.30
Hydrophobic	ICL3	S	307	-	S6	R	85	N.S6.03
Hydrophobic	ICL2	Q	151	-	s15s16	Y	254	C.s15s16.03
Hydrophobic	TM6	T	322	6x36	s5s6	I	79	N.s5s6.08
Hydrophobic	TM5	P	239	5x75	s9s10	D	162	N.s9s10.04
Hydrophobic	C-term	L	523	-	s17s18	R	322	C.s17s18.38
Hydrophobic	ICL1	F	75	12x50	S8	L	136	N.S8.03
Hydrophobic	TM5	Y	222	5x58	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL1	A	71	-	s8s9	Q	141	N.s8s9.05
Hydrophobic	TM7	R	378	7x55	s5s6	D	75	N.s5s6.04
Hydrophobic	ICL3	I	309	-	S6	F	83	N.S6.01
Hydrophobic	TM3	V	147	3x54	s5s6	L	81	N.s5s6.10
Hydrophobic	TM7	I	375	7x52	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL1	F	75	12x50	s8s9	D	142	N.s8s9.06
Hydrophobic	TM6	K	318	6x32	s5s6	G	80	N.s5s6.09
Hydrophobic	TM3	R	143	3x50	s5s6	V	78	N.s5s6.07
Hydrophobic	C-term	G	507	-	s11s12	F	201	C.s11s12.02
Hydrophobic	ICL1	F	75	12x50	S16	Y	259	C.S16.03
Hydrophobic	ICL2	T	155	-	s15s16	S	256	C.s15s16.05
Hydrophobic	TM7	R	378	7x55	s8s9	K	145	N.s8s9.09
Hydrophobic	ICL1	K	74	12x49	S16	Y	259	C.S16.03
Hydrophobic	C-term	Y	517	-	s10s11	R	193	C.s10s11.10
Hydrophobic	C-term	L	523	-	S18	L	328	C.S18.02
Hydrophobic	TM6	L	311	6x25	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL3	L	305	-	s17s18	V	324	C.s17s18.40
Hydrophobic	ICL3	L	303	-	s7s8	Y	129	N.s7s8.05
Hydrophobic	TM6	S	312	6x26	s9s10	D	166	N.s9s10.08
Hydrophobic	C-term	Y	517	-	S11	A	194	C.S11.01
Hydrophobic	ICL1	F	75	12x50	s8s9	K	145	N.s8s9.09
Hydrophobic	ICL3	L	305	-	S6	R	85	N.S6.03
Hydrophobic	TM6	C	323	6x37	s5s6	I	79	N.s5s6.08
Hydrophobic	H8	S	380	8x47	s5s6	V	78	N.s5s6.07
Hydrophobic	C-term	Q	525	-	s17s18	R	322	C.s17s18.38
Hydrophobic	TM6	K	315	6x29	s5s6	T	82	N.s5s6.11
Hydrophobic	TM5	P	240	5x76	s9s10	A	163	N.s9s10.05
Hydrophobic	ICL1	F	75	12x50	s8s9	P	138	N.s8s9.02
Hydrophobic	C-term	Y	517	-	S19	P	356	C.S19.08
Hydrophobic	ICL1	F	72	-	s8s9	D	142	N.s8s9.06
Hydrophobic	C-term	D	522	-	s17s18	I	316	C.s17s18.32
Hydrophobic	C-term	L	523	-	s17s18	I	316	C.s17s18.32
Hydrophobic	TM3	M	146	3x53	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL1	F	75	12x50	s17s18	G	296	C.s17s18.12
Hydrophobic	ICL1	A	71	-	s8s9	D	142	N.s8s9.06
Hydrophobic	TM6	A	319	6x33	s5s6	I	79	N.s5s6.08
Hydrophobic	TM6	L	311	6x25	s5s6	T	82	N.s5s6.11
Hydrophobic	C-term	M	515	-	S11	A	194	C.S11.01
Hydrophobic	TM6	A	319	6x33	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL3	I	309	-	s5s6	I	76	N.s5s6.05
Hydrophobic	TM7	Y	376	7x53	s5s6	V	78	N.s5s6.07
Ionic	H8	R	385	8x52	s5s6	E	74	N.s5s6.03
Ionic	C-term	D	522	-	S19	R	358	C.S19.10
Ionic	TM7	R	378	7x55	s5s6	D	75	N.s5s6.04
Ionic	TM6	K	318	6x32	s5s6	D	77	N.s5s6.06
Polar	TM6	N	310	6x24	S6	R	84	N.S6.02
Polar	H8	R	384	8x51	s5s6	V	78	N.s5s6.07
Polar	TM6	N	310	6x24	S6	D	86	N.S6.04
Polar	TM6	T	313	6x27	s9s10	D	166	N.s9s10.08
Polar	TM7	R	378	7x55	S5	Y	71	N.S5.12
Polar	C-term	D	522	-	S19	R	358	C.S19.10
Polar	C-term	Y	517	-	S19	V	355	C.S19.07
Polar	C-term	Y	517	-	S19	E	354	C.S19.06
Polar	ICL2	Q	151	-	s15s16	Y	254	C.s15s16.03
Polar	TM5	P	240	5x76	S6	R	91	N.S6.09
Polar	C-term	L	523	-	s17s18	R	322	C.s17s18.38
Polar	TM7	R	378	7x55	s5s6	D	75	N.s5s6.04
Polar	ICL2	T	155	-	s15s16	S	256	C.s15s16.05
Polar	C-term	T	520	-	S19	R	358	C.S19.10
Polar	ICL1	F	75	12x50	s8s9	K	145	N.s8s9.09
Polar	ICL3	L	305	-	S6	R	85	N.S6.03
Polar	ICL2	Q	151	-	s15s16	S	255	C.s15s16.04
Polar	C-term	Q	525	-	s17s18	R	322	C.s17s18.38
Polar	TM6	K	315	6x29	s5s6	T	82	N.s5s6.11
Polar	ICL3	V	306	-	S6	R	85	N.S6.03
Polar	ICL2	Q	151	-	s15s16	V	252	C.s15s16.01
Polar	ICL1	F	72	-	s8s9	D	142	N.s8s9.06
Polar	TM6	A	319	6x33	s5s6	I	79	N.s5s6.08
Polar	C-term	A	514	-	S11	E	195	C.S11.02
Polar	C-term	D	522	-	s17s18	R	322	C.s17s18.38
Polar	C-term	Y	512	-	S11	A	197	C.S11.04
Van-der-waals	ICL2	Q	151	-	s15s16	L	253	C.s15s16.02
Van-der-waals	C-term	S	511	-	S11	W	198	C.S11.05
Van-der-waals	TM6	N	310	6x24	S6	R	84	N.S6.02
Van-der-waals	C-term	H	518	-	s10s11	P	190	C.s10s11.07
Van-der-waals	ICL3	I	309	-	S6	R	84	N.S6.02
Van-der-waals	TM6	N	310	6x24	S6	D	86	N.S6.04
Van-der-waals	ICL1	K	74	12x49	S16	K	261	C.S16.05
Van-der-waals	TM6	T	313	6x27	s9s10	D	166	N.s9s10.08
Van-der-waals	TM5	K	237	5x73	s9s10	E	164	N.s9s10.06
Van-der-waals	TM7	R	378	7x55	S5	Y	71	N.S5.12
Van-der-waals	TM6	T	322	6x36	s5s6	V	78	N.s5s6.07
Van-der-waals	ICL1	F	72	-	s8s9	Q	141	N.s8s9.05
Van-der-waals	TM7	R	378	7x55	s5s6	V	78	N.s5s6.07
Van-der-waals	TM2	T	77	2x37	S16	D	257	C.S16.01
Van-der-waals	ICL1	F	72	-	s8s9	K	145	N.s8s9.09
Van-der-waals	TM7	S	377	7x54	s5s6	V	78	N.s5s6.07
Van-der-waals	C-term	Y	517	-	S19	E	354	C.S19.06
Van-der-waals	TM5	L	229	5x65	s5s6	L	81	N.s5s6.10
Van-der-waals	C-term	A	509	-	S11	Q	199	C.S11.06
Van-der-waals	C-term	L	523	-	s17s18	T	314	C.s17s18.30
Van-der-waals	ICL3	S	307	-	S6	R	85	N.S6.03
Van-der-waals	ICL2	Q	151	-	s15s16	Y	254	C.s15s16.03
Van-der-waals	TM5	P	239	5x75	s9s10	D	162	N.s9s10.04
Van-der-waals	C-term	S	511	-	S11	A	197	C.S11.04
Van-der-waals	C-term	L	523	-	s17s18	R	322	C.s17s18.38
Van-der-waals	ICL1	A	71	-	s8s9	Q	141	N.s8s9.05
Van-der-waals	TM7	R	378	7x55	s5s6	D	75	N.s5s6.04
Van-der-waals	ICL3	I	309	-	S6	F	83	N.S6.01
Van-der-waals	TM7	I	375	7x52	s5s6	V	78	N.s5s6.07
Van-der-waals	ICL1	F	75	12x50	s8s9	D	142	N.s8s9.06
Van-der-waals	TM3	R	143	3x50	s5s6	V	78	N.s5s6.07
Van-der-waals	C-term	G	507	-	s11s12	F	201	C.s11s12.02
Van-der-waals	ICL1	F	75	12x50	S16	Y	259	C.S16.03
Van-der-waals	ICL2	T	155	-	s15s16	S	256	C.s15s16.05
Van-der-waals	TM7	R	378	7x55	s8s9	K	145	N.s8s9.09
Van-der-waals	ICL1	K	74	12x49	S16	Y	259	C.S16.03
Van-der-waals	C-term	T	520	-	S19	R	358	C.S19.10
Van-der-waals	TM6	L	311	6x25	s5s6	L	81	N.s5s6.10
Van-der-waals	ICL3	L	305	-	s17s18	V	324	C.s17s18.40
Van-der-waals	ICL3	L	303	-	s7s8	Y	129	N.s7s8.05
Van-der-waals	ICL1	F	75	12x50	s8s9	K	145	N.s8s9.09
Van-der-waals	ICL3	L	305	-	S6	R	85	N.S6.03
Van-der-waals	TM6	C	323	6x37	s5s6	I	79	N.s5s6.08
Van-der-waals	ICL2	Q	151	-	s15s16	S	255	C.s15s16.04
Van-der-waals	C-term	Q	525	-	s17s18	R	322	C.s17s18.38
Van-der-waals	TM6	K	315	6x29	s5s6	T	82	N.s5s6.11
Van-der-waals	TM5	P	240	5x76	s9s10	A	163	N.s9s10.05
Van-der-waals	ICL2	Q	151	-	s15s16	V	252	C.s15s16.01
Van-der-waals	C-term	Y	517	-	S19	P	356	C.S19.08
Van-der-waals	ICL1	F	72	-	s8s9	D	142	N.s8s9.06
Van-der-waals	C-term	D	522	-	s17s18	I	316	C.s17s18.32
Van-der-waals	C-term	L	523	-	s17s18	I	316	C.s17s18.32
Van-der-waals	TM3	M	146	3x53	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL1	A	71	-	s8s9	D	142	N.s8s9.06
Van-der-waals	TM6	A	319	6x33	s5s6	I	79	N.s5s6.08
Van-der-waals	TM6	L	311	6x25	s5s6	T	82	N.s5s6.11
Van-der-waals	C-term	A	514	-	S11	E	195	C.S11.02
Van-der-waals	TM6	A	319	6x33	s5s6	L	81	N.s5s6.10
Van-der-waals	C-term	D	522	-	s17s18	R	322	C.s17s18.38
Van-der-waals	C-term	Y	512	-	S11	A	197	C.S11.04

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Main reference

S-arrestin - GPR75 complex model Download Full