S-arrestin - GPR75 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR75 57.4
S-arrestin 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 20.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Q 151 - s15s16 L 253 C.s15s16.02
Van-der-waals ICL2 Q 151 - s15s16 L 253 C.s15s16.02
Hydrophobic C-term S 511 - S11 W 198 C.S11.05
Van-der-waals C-term S 511 - S11 W 198 C.S11.05
Polar TM6 N 310 6x24 S6 R 84 N.S6.02
Hydrophobic TM6 N 310 6x24 S6 R 84 N.S6.02
Van-der-waals TM6 N 310 6x24 S6 R 84 N.S6.02
Polar H8 R 384 8x51 s5s6 V 78 N.s5s6.07
Hydrophobic C-term H 518 - s10s11 P 190 C.s10s11.07
Van-der-waals C-term H 518 - s10s11 P 190 C.s10s11.07
Hydrophobic ICL3 I 309 - S6 R 84 N.S6.02
Van-der-waals ICL3 I 309 - S6 R 84 N.S6.02
Polar TM6 N 310 6x24 S6 D 86 N.S6.04
Hydrophobic TM6 N 310 6x24 S6 D 86 N.S6.04
Van-der-waals TM6 N 310 6x24 S6 D 86 N.S6.04
Hydrophobic ICL1 K 74 12x49 S16 K 261 C.S16.05
Van-der-waals ICL1 K 74 12x49 S16 K 261 C.S16.05
Polar TM6 T 313 6x27 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 T 313 6x27 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 T 313 6x27 s9s10 D 166 N.s9s10.08
Ionic H8 R 385 8x52 s5s6 E 74 N.s5s6.03
Hydrophobic TM5 K 237 5x73 s9s10 E 164 N.s9s10.06
Van-der-waals TM5 K 237 5x73 s9s10 E 164 N.s9s10.06
Polar TM7 R 378 7x55 S5 Y 71 N.S5.12
Van-der-waals TM7 R 378 7x55 S5 Y 71 N.S5.12
Ionic C-term D 522 - S19 R 358 C.S19.10
Polar C-term D 522 - S19 R 358 C.S19.10
Hydrophobic TM6 T 322 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 T 322 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 143 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic C-term I 513 - S11 A 196 C.S11.03
Hydrophobic ICL1 F 72 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 F 72 - s8s9 Q 141 N.s8s9.05
Hydrophobic C-term T 519 - S19 P 356 C.S19.08
Hydrophobic TM7 R 378 7x55 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 R 378 7x55 s5s6 V 78 N.s5s6.07
Polar C-term Y 517 - S19 V 355 C.S19.07
Hydrophobic C-term Y 517 - S19 V 355 C.S19.07
Hydrophobic TM2 T 77 2x37 S16 D 257 C.S16.01
Van-der-waals TM2 T 77 2x37 S16 D 257 C.S16.01
Hydrophobic TM6 L 311 6x25 S6 F 83 N.S6.01
Hydrophobic ICL1 F 72 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL1 F 72 - s8s9 K 145 N.s8s9.09
Hydrophobic TM7 S 377 7x54 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 S 377 7x54 s5s6 V 78 N.s5s6.07
Polar C-term Y 517 - S19 E 354 C.S19.06
Hydrophobic C-term Y 517 - S19 E 354 C.S19.06
Van-der-waals C-term Y 517 - S19 E 354 C.S19.06
Hydrophobic TM5 L 229 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 229 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic C-term A 509 - S11 Q 199 C.S11.06
Van-der-waals C-term A 509 - S11 Q 199 C.S11.06
Hydrophobic C-term L 523 - s17s18 T 314 C.s17s18.30
Van-der-waals C-term L 523 - s17s18 T 314 C.s17s18.30
Hydrophobic ICL3 S 307 - S6 R 85 N.S6.03
Van-der-waals ICL3 S 307 - S6 R 85 N.S6.03
Polar ICL2 Q 151 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 Q 151 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 Q 151 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 T 322 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 P 239 5x75 s9s10 D 162 N.s9s10.04
Van-der-waals TM5 P 239 5x75 s9s10 D 162 N.s9s10.04
Polar TM5 P 240 5x76 S6 R 91 N.S6.09
Van-der-waals C-term S 511 - S11 A 197 C.S11.04
Polar C-term L 523 - s17s18 R 322 C.s17s18.38
Hydrophobic C-term L 523 - s17s18 R 322 C.s17s18.38
Van-der-waals C-term L 523 - s17s18 R 322 C.s17s18.38
Hydrophobic ICL1 F 75 12x50 S8 L 136 N.S8.03
Hydrophobic TM5 Y 222 5x58 s5s6 I 79 N.s5s6.08
Hydrophobic ICL1 A 71 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 A 71 - s8s9 Q 141 N.s8s9.05
Ionic TM7 R 378 7x55 s5s6 D 75 N.s5s6.04
Polar TM7 R 378 7x55 s5s6 D 75 N.s5s6.04
Hydrophobic TM7 R 378 7x55 s5s6 D 75 N.s5s6.04
Van-der-waals TM7 R 378 7x55 s5s6 D 75 N.s5s6.04
Hydrophobic ICL3 I 309 - S6 F 83 N.S6.01
Van-der-waals ICL3 I 309 - S6 F 83 N.S6.01
Hydrophobic TM3 V 147 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM7 I 375 7x52 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 I 375 7x52 s5s6 V 78 N.s5s6.07
Hydrophobic ICL1 F 75 12x50 s8s9 D 142 N.s8s9.06
Van-der-waals ICL1 F 75 12x50 s8s9 D 142 N.s8s9.06
Hydrophobic TM6 K 318 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM3 R 143 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 143 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic C-term G 507 - s11s12 F 201 C.s11s12.02
Van-der-waals C-term G 507 - s11s12 F 201 C.s11s12.02
Aromatic ICL1 F 75 12x50 S16 Y 259 C.S16.03
Hydrophobic ICL1 F 75 12x50 S16 Y 259 C.S16.03
Van-der-waals ICL1 F 75 12x50 S16 Y 259 C.S16.03
Polar ICL2 T 155 - s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 T 155 - s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 T 155 - s15s16 S 256 C.s15s16.05
Hydrophobic TM7 R 378 7x55 s8s9 K 145 N.s8s9.09
Van-der-waals TM7 R 378 7x55 s8s9 K 145 N.s8s9.09
Hydrophobic ICL1 K 74 12x49 S16 Y 259 C.S16.03
Van-der-waals ICL1 K 74 12x49 S16 Y 259 C.S16.03
Polar C-term T 520 - S19 R 358 C.S19.10
Van-der-waals C-term T 520 - S19 R 358 C.S19.10
Hydrophobic C-term Y 517 - s10s11 R 193 C.s10s11.10
Hydrophobic C-term L 523 - S18 L 328 C.S18.02
Hydrophobic TM6 L 311 6x25 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 L 311 6x25 s5s6 L 81 N.s5s6.10
Hydrophobic ICL3 L 305 - s17s18 V 324 C.s17s18.40
Van-der-waals ICL3 L 305 - s17s18 V 324 C.s17s18.40
Hydrophobic ICL3 L 303 - s7s8 Y 129 N.s7s8.05
Van-der-waals ICL3 L 303 - s7s8 Y 129 N.s7s8.05
Ionic TM6 K 318 6x32 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 S 312 6x26 s9s10 D 166 N.s9s10.08
Hydrophobic C-term Y 517 - S11 A 194 C.S11.01
Polar ICL1 F 75 12x50 s8s9 K 145 N.s8s9.09
Hydrophobic ICL1 F 75 12x50 s8s9 K 145 N.s8s9.09
Van-der-waals ICL1 F 75 12x50 s8s9 K 145 N.s8s9.09
Polar ICL3 L 305 - S6 R 85 N.S6.03
Hydrophobic ICL3 L 305 - S6 R 85 N.S6.03
Van-der-waals ICL3 L 305 - S6 R 85 N.S6.03
Hydrophobic TM6 C 323 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 C 323 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic H8 S 380 8x47 s5s6 V 78 N.s5s6.07
Polar ICL2 Q 151 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 Q 151 - s15s16 S 255 C.s15s16.04
Polar C-term Q 525 - s17s18 R 322 C.s17s18.38
Hydrophobic C-term Q 525 - s17s18 R 322 C.s17s18.38
Van-der-waals C-term Q 525 - s17s18 R 322 C.s17s18.38
Polar TM6 K 315 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 K 315 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 K 315 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM5 P 240 5x76 s9s10 A 163 N.s9s10.05
Van-der-waals TM5 P 240 5x76 s9s10 A 163 N.s9s10.05
Polar ICL3 V 306 - S6 R 85 N.S6.03
Hydrophobic ICL1 F 75 12x50 s8s9 P 138 N.s8s9.02
Polar ICL2 Q 151 - s15s16 V 252 C.s15s16.01
Van-der-waals ICL2 Q 151 - s15s16 V 252 C.s15s16.01
Hydrophobic C-term Y 517 - S19 P 356 C.S19.08
Van-der-waals C-term Y 517 - S19 P 356 C.S19.08
Polar ICL1 F 72 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL1 F 72 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL1 F 72 - s8s9 D 142 N.s8s9.06
Hydrophobic C-term D 522 - s17s18 I 316 C.s17s18.32
Van-der-waals C-term D 522 - s17s18 I 316 C.s17s18.32
Hydrophobic C-term L 523 - s17s18 I 316 C.s17s18.32
Van-der-waals C-term L 523 - s17s18 I 316 C.s17s18.32
Hydrophobic TM3 M 146 3x53 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 M 146 3x53 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL1 F 75 12x50 s17s18 G 296 C.s17s18.12
Hydrophobic ICL1 A 71 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL1 A 71 - s8s9 D 142 N.s8s9.06
Polar TM6 A 319 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 A 319 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 319 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 L 311 6x25 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 L 311 6x25 s5s6 T 82 N.s5s6.11
Polar C-term A 514 - S11 E 195 C.S11.02
Van-der-waals C-term A 514 - S11 E 195 C.S11.02
Hydrophobic C-term M 515 - S11 A 194 C.S11.01
Hydrophobic TM6 A 319 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 319 6x33 s5s6 L 81 N.s5s6.10
Polar C-term D 522 - s17s18 R 322 C.s17s18.38
Van-der-waals C-term D 522 - s17s18 R 322 C.s17s18.38
Hydrophobic ICL3 I 309 - s5s6 I 76 N.s5s6.05
Polar C-term Y 512 - S11 A 197 C.S11.04
Van-der-waals C-term Y 512 - S11 A 197 C.S11.04
Hydrophobic TM7 Y 376 7x53 s5s6 V 78 N.s5s6.07