Beta-arrestin-2 - GPR78 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR78 76.6
Beta-arrestin-2 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 M 206 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 M 206 5x72 S6 R 77 N.S6.02
Hydrophobic H8 R 298 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 R 298 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 112 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 112 34x51 S16 A 248 C.S16.01
Hydrophobic ICL3 C 228 - S6 D 79 N.S6.04
Ionic ICL3 R 227 - s9s10 E 156 N.s9s10.07
Polar ICL3 R 227 - s9s10 E 156 N.s9s10.07
Hydrophobic ICL3 R 227 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 R 227 - s9s10 E 156 N.s9s10.07
Polar TM2 R 39 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 R 39 2x37 s8s9 T 137 N.s8s9.07
Polar TM6 R 235 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 R 235 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 R 235 6x29 S6 R 77 N.S6.02
Polar H8 R 299 8x48 s20c Q 407 C.s20c.17
Hydrophobic H8 R 299 8x48 s20c Q 407 C.s20c.17
Van-der-waals H8 R 299 8x48 s20c Q 407 C.s20c.17
Polar ICL3 R 227 - s9s10 L 155 N.s9s10.03
Hydrophobic ICL3 R 227 - s9s10 L 155 N.s9s10.03
Van-der-waals ICL3 R 227 - s9s10 L 155 N.s9s10.03
Polar TM5 T 210 5x76 S6 D 79 N.S6.04
Ionic TM2 R 39 2x37 s5s6 D 68 N.s5s6.04
Polar TM2 R 39 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 39 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 39 2x37 s5s6 D 68 N.s5s6.04
Polar ICL2 A 115 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 115 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 115 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 112 34x51 s15s16 S 246 C.s15s16.04
Polar TM6 R 235 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 235 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM3 V 108 3x54 S6 F 76 N.S6.01
Hydrophobic ICL3 P 222 - S6 F 81 N.S6.06
Van-der-waals ICL3 P 222 - S6 F 81 N.S6.06
Hydrophobic TM6 I 243 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 243 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 M 206 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 M 206 5x72 S6 K 78 N.S6.03
Polar TM5 R 205 5x71 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 205 5x71 s15s16 F 245 C.s15s16.03
Polar ICL2 L 112 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 112 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 112 34x51 S16 Y 250 C.S16.03
Polar H8 R 299 8x48 s20c L 408 C.s20c.18
Hydrophobic H8 R 299 8x48 s20c L 408 C.s20c.18
Van-der-waals H8 R 299 8x48 s20c L 408 C.s20c.18
Hydrophobic TM3 V 108 3x54 s5s6 L 72 N.s5s6.08
Polar ICL2 A 115 34x54 s17s18 R 286 C.s17s18.11
Hydrophobic TM5 A 199 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 A 199 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 V 195 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 V 195 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 V 209 5x75 s17s18 E 314 C.s17s18.39
Polar H8 R 299 8x48 s20c C 409 C.s20c.19
Van-der-waals H8 R 299 8x48 s20c C 409 C.s20c.19
Hydrophobic TM4 R 119 4x38 s5s6 R 66 N.s5s6.02
Van-der-waals TM4 R 119 4x38 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 Q 104 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 Q 104 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 P 111 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 111 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 112 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 112 34x51 S15 I 242 C.S15.14
Hydrophobic TM5 A 199 5x65 S6 F 76 N.S6.01
Hydrophobic TM5 V 195 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 A 107 3x53 s5s6 L 69 N.s5s6.05
Polar H8 Q 303 8x52 s20c Q 407 C.s20c.17
Hydrophobic H8 Q 303 8x52 s20c Q 407 C.s20c.17
Van-der-waals H8 Q 303 8x52 s20c Q 407 C.s20c.17
Hydrophobic ICL2 L 112 34x51 S5 Y 64 N.S5.12
Polar TM5 H 202 5x68 s15s16 F 245 C.s15s16.03
Aromatic TM5 H 202 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 202 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 202 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 L 112 34x51 S8 L 130 N.S8.03
Aromatic TM5 H 202 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 H 202 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 H 202 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 V 209 5x75 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 V 209 5x75 s17s18 V 315 C.s17s18.40
Polar TM6 K 242 6x36 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 K 242 6x36 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 K 242 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 K 242 6x36 s5s6 L 72 N.s5s6.08
Polar ICL1 E 35 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 E 35 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 E 35 12x49 s20c Y 404 C.s20c.14
Polar TM6 A 239 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 239 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 239 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 K 242 6x36 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 V 108 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 108 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 V 209 5x75 S6 K 78 N.S6.03
Van-der-waals TM5 V 209 5x75 S6 K 78 N.S6.03
Hydrophobic ICL2 A 115 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 A 115 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL3 K 212 - s17s18 N 312 C.s17s18.37
Hydrophobic ICL3 A 213 - S6 L 80 N.S6.05
Van-der-waals ICL3 A 213 - S6 L 80 N.S6.05
Hydrophobic TM6 A 239 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 239 6x33 s5s6 L 74 N.s5s6.10
Ionic TM4 R 119 4x38 s5s6 D 68 N.s5s6.04
Polar ICL1 E 35 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 E 35 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 E 35 12x49 s8s9 T 137 N.s8s9.07
Polar TM6 K 242 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 K 242 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 K 242 6x36 s5s6 V 71 N.s5s6.07
Ionic H8 R 299 8x48 s5s6 D 70 N.s5s6.06
Polar H8 R 299 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 V 224 - S6 I 82 N.S6.07
Van-der-waals ICL3 V 224 - S6 I 82 N.S6.07
Hydrophobic TM5 M 206 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 M 206 5x72 s15s16 F 245 C.s15s16.03