Beta-arrestin-2 - GPR82 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
GPR82 76.5
Beta-arrestin-2 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 247 6x33 s5s6 G 73 N.s5s6.09
Polar TM3 R 117 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 117 3x50 s5s6 V 71 N.s5s6.07
Polar H8 K 318 8x52 s20c D 403 C.s20c.13
Van-der-waals H8 K 318 8x52 s20c D 403 C.s20c.13
Hydrophobic TM5 F 224 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 F 224 5x61 s5s6 L 72 N.s5s6.08
Polar H8 K 314 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 I 237 6x23 S6 K 78 N.S6.03
Hydrophobic TM5 I 231 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 R 117 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 117 3x50 s5s6 L 72 N.s5s6.08
Polar H8 K 318 8x52 s20c Q 407 C.s20c.17
Hydrophobic H8 K 318 8x52 s20c Q 407 C.s20c.17
Van-der-waals H8 K 318 8x52 s20c Q 407 C.s20c.17
Polar H8 K 314 8x48 s5s6 G 73 N.s5s6.09
Hydrophobic H8 K 314 8x48 s5s6 G 73 N.s5s6.09
Van-der-waals H8 K 314 8x48 s5s6 G 73 N.s5s6.09
Hydrophobic TM5 L 228 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 T 235 - S6 K 78 N.S6.03
Hydrophobic TM3 L 121 3x54 s15s16 F 245 C.s15s16.03
Polar ICL2 Q 128 - s17s18 E 314 C.s17s18.39
Hydrophobic TM6 T 243 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 T 243 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 I 237 6x23 S6 R 77 N.S6.02
Van-der-waals TM6 I 237 6x23 S6 R 77 N.S6.02
Polar TM6 H 250 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 H 250 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 247 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 247 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 I 231 5x68 S6 F 76 N.S6.01
Hydrophobic ICL1 K 46 - s5s6 E 67 N.s5s6.03
Hydrophobic TM3 L 121 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM7 L 312 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 T 50 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 T 50 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 T 243 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 K 124 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 K 124 - s5s6 R 66 N.s5s6.02
Polar TM3 T 120 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 T 120 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 T 120 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM2 H 51 2x40 s5s6 E 67 N.s5s6.03
Hydrophobic TM6 V 247 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 247 6x33 s5s6 L 72 N.s5s6.08
Polar TM7 L 312 7x56 s5s6 G 73 N.s5s6.09
Polar TM2 T 50 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 50 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 50 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM4 P 149 4x39 s8s9 T 137 N.s8s9.07
Polar TM2 S 49 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 H 51 2x40 s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 K 46 - s8s9 P 134 N.s8s9.04
Van-der-waals ICL1 K 46 - s8s9 P 134 N.s8s9.04
Polar ICL1 K 46 - s8s9 P 132 N.s8s9.02
Van-der-waals ICL1 K 46 - s8s9 P 132 N.s8s9.02
Hydrophobic ICL2 K 124 - s5s6 L 69 N.s5s6.05
Ionic TM6 E 239 6x25 S9 R 148 N.S9.08
Polar TM6 E 239 6x25 S9 R 148 N.S9.08
Van-der-waals TM6 E 239 6x25 S9 R 148 N.S9.08
Hydrophobic TM3 T 120 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 K 124 - S5 Y 64 N.S5.12
Van-der-waals ICL2 K 124 - S5 Y 64 N.S5.12
Ionic TM6 E 239 6x25 S10 R 166 N.S10.03
Polar TM6 K 240 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 K 240 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 K 240 6x26 S6 R 77 N.S6.02
Hydrophobic TM2 L 54 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 121 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 K 124 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 K 124 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 K 124 - s15s16 F 245 C.s15s16.03
Hydrophobic TM6 I 237 6x23 S6 D 79 N.S6.04
Van-der-waals TM6 I 237 6x23 S6 D 79 N.S6.04
Hydrophobic TM5 F 224 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 F 224 5x61 s5s6 L 74 N.s5s6.10
Polar TM2 T 48 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 48 2x37 s5s6 D 68 N.s5s6.04
Polar ICL1 K 46 - s8s9 G 133 N.s8s9.03
Hydrophobic ICL1 K 46 - s8s9 G 133 N.s8s9.03
Van-der-waals ICL1 K 46 - s8s9 G 133 N.s8s9.03
Hydrophobic TM6 L 251 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 251 6x37 s5s6 L 72 N.s5s6.08
Polar H8 D 313 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 D 313 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 T 120 3x53 s5s6 L 69 N.s5s6.05
Aromatic TM6 K 240 6x26 S6 F 76 N.S6.01
Hydrophobic TM6 K 240 6x26 S6 F 76 N.S6.01
Van-der-waals TM6 K 240 6x26 S6 F 76 N.S6.01
Hydrophobic TM2 T 48 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 T 48 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 K 124 - s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 K 124 - s15s16 S 246 C.s15s16.04
Ionic TM6 E 239 6x25 S6 R 77 N.S6.02
Polar TM6 E 239 6x25 S6 R 77 N.S6.02
Van-der-waals TM6 E 239 6x25 S6 R 77 N.S6.02
Hydrophobic ICL2 R 147 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 147 34x57 s5s6 R 66 N.s5s6.02
Polar ICL2 S 127 - s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 S 127 - s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 S 127 - s15s16 T 247 C.s15s16.05