S-arrestin - GPR82 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR82 75.9
S-arrestin 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 247 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 V 247 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 247 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 L 228 5x65 s15s16 Y 254 C.s15s16.03
Ionic TM6 K 240 6x26 s9s10 E 164 N.s9s10.06
Polar TM6 K 240 6x26 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 K 240 6x26 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 K 240 6x26 s9s10 E 164 N.s9s10.06
Hydrophobic TM1 F 40 1x57 s5s6 V 78 N.s5s6.07
Polar ICL2 K 124 - s15s16 S 256 C.s15s16.05
Hydrophobic H8 K 326 8x60 s20c R 398 C.s20c.17
Van-der-waals H8 K 326 8x60 s20c R 398 C.s20c.17
Hydrophobic TM2 H 51 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 H 51 2x40 s5s6 V 78 N.s5s6.07
Ionic ICL2 R 147 34x57 S16 D 257 C.S16.01
Hydrophobic TM7 L 312 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 I 237 6x23 S6 L 87 N.S6.05
Van-der-waals TM6 I 237 6x23 S6 L 87 N.S6.05
Van-der-waals TM6 T 243 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM3 I 113 3x46 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 L 242 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 L 242 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 I 237 6x23 S6 D 86 N.S6.04
Van-der-waals TM6 I 237 6x23 S6 D 86 N.S6.04
Hydrophobic TM5 I 231 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 L 121 3x54 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 E 239 6x25 S6 F 89 N.S6.07
Van-der-waals TM6 E 239 6x25 S6 F 89 N.S6.07
Hydrophobic ICL1 K 46 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL1 K 46 - s5s6 Q 73 N.s5s6.02
Hydrophobic TM6 L 251 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 F 309 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 L 312 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 F 224 5x61 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 F 224 5x61 s5s6 L 81 N.s5s6.10
Polar ICL2 K 124 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 K 124 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 K 124 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL1 K 46 - s8s9 P 140 N.s8s9.04
Polar TM6 T 243 6x29 S6 R 84 N.S6.02
Hydrophobic TM6 T 243 6x29 S6 R 84 N.S6.02
Van-der-waals TM6 T 243 6x29 S6 R 84 N.S6.02
Polar H8 D 313 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 D 313 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 D 313 8x47 s5s6 V 78 N.s5s6.07
Polar ICL2 K 124 - S5 Y 71 N.S5.12
Aromatic ICL2 K 124 - S5 Y 71 N.S5.12
Hydrophobic ICL2 K 124 - S5 Y 71 N.S5.12
Van-der-waals ICL2 K 124 - S5 Y 71 N.S5.12
Hydrophobic TM6 L 242 6x28 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 L 242 6x28 s9s10 E 165 N.s9s10.07
Hydrophobic TM5 L 228 5x65 S6 F 83 N.S6.01
Polar H8 T 315 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 T 315 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 T 315 8x49 s5s6 D 75 N.s5s6.04
Polar ICL3 C 234 - S6 R 85 N.S6.03
Polar H8 K 314 8x48 s5s6 T 82 N.s5s6.11
Polar TM6 H 250 6x36 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 H 250 6x36 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 H 250 6x36 s5s6 G 80 N.s5s6.09
Polar ICL3 T 235 - S6 R 85 N.S6.03
Hydrophobic ICL3 T 235 - S6 R 85 N.S6.03
Van-der-waals ICL3 T 235 - S6 R 85 N.S6.03
Hydrophobic TM3 R 117 3x50 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 R 117 3x50 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 I 254 6x40 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 254 6x40 s5s6 I 79 N.s5s6.08
Ionic ICL2 K 144 34x54 S16 D 257 C.S16.01
Polar ICL2 K 144 34x54 S16 D 257 C.S16.01
Hydrophobic ICL2 K 144 34x54 S16 D 257 C.S16.01
Van-der-waals ICL2 K 144 34x54 S16 D 257 C.S16.01
Polar ICL2 K 124 - s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 K 124 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 K 124 - s15s16 S 255 C.s15s16.04
Hydrophobic TM6 L 242 6x28 s9s10 E 164 N.s9s10.06
Polar H8 D 313 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 D 313 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 D 313 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 I 237 6x23 S6 R 85 N.S6.03
Van-der-waals TM6 I 237 6x23 S6 R 85 N.S6.03
Hydrophobic TM2 T 48 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 T 48 2x37 s5s6 Q 73 N.s5s6.02
Ionic H8 K 314 8x48 s5s6 D 77 N.s5s6.06
Polar H8 K 314 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 314 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 314 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic ICL1 K 46 - s8s9 S 143 N.s8s9.07
Van-der-waals ICL1 K 46 - s8s9 S 143 N.s8s9.07
Hydrophobic TM2 L 54 2x43 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 L 54 2x43 s5s6 V 78 N.s5s6.07
Polar TM5 I 231 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 I 231 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 I 231 5x68 S6 R 85 N.S6.03
Van-der-waals TM7 L 312 7x56 s5s6 D 77 N.s5s6.06
Polar ICL2 S 127 - s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 S 127 - s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 S 127 - s15s16 S 256 C.s15s16.05
Polar TM6 H 250 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 H 250 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 H 250 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 L 121 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 L 121 3x54 S6 F 83 N.S6.01
Polar TM7 L 312 7x56 s5s6 G 80 N.s5s6.09
Van-der-waals TM7 L 312 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM5 F 224 5x61 S6 F 83 N.S6.01
Van-der-waals TM5 F 224 5x61 S6 F 83 N.S6.01
Hydrophobic TM3 R 117 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 117 3x50 s5s6 I 79 N.s5s6.08