Arrestin-C - GPR83 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR83 67.5
Arrestin-C 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 176 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 176 - s15s16 S 242 C.s15s16.04
Polar TM6 Q 279 6x22 S6 D 74 N.S6.04
Hydrophobic TM6 Q 279 6x22 S6 D 74 N.S6.04
Van-der-waals TM6 Q 279 6x22 S6 D 74 N.S6.04
Polar TM5 I 272 5x71 S6 K 73 N.S6.03
Hydrophobic TM5 I 272 5x71 S6 K 73 N.S6.03
Van-der-waals TM5 I 272 5x71 S6 K 73 N.S6.03
Polar TM7 L 348 7x56 s5s6 G 68 N.s5s6.09
Van-der-waals TM7 L 348 7x56 s5s6 G 68 N.s5s6.09
Polar TM4 S 182 4x38 s8s9 E 131 N.s8s9.05
Hydrophobic TM4 S 182 4x38 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 S 182 4x38 s8s9 E 131 N.s8s9.05
Hydrophobic TM2 T 106 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 106 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 I 272 5x71 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 I 272 5x71 s17s18 L 311 C.s17s18.40
Ionic ICL1 R 101 12x49 s20c E 383 C.s20c.17
Polar ICL1 R 101 12x49 s20c E 383 C.s20c.17
Hydrophobic ICL1 R 101 12x49 s20c E 383 C.s20c.17
Van-der-waals ICL1 R 101 12x49 s20c E 383 C.s20c.17
Polar ICL2 P 176 - S16 D 244 C.S16.01
Hydrophobic ICL2 L 177 - S15 V 238 C.S15.14
Van-der-waals ICL2 L 177 - S15 V 238 C.S15.14
Polar ICL2 K 178 - S16 Y 246 C.S16.03
Hydrophobic TM3 I 173 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 L 266 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 V 172 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 V 172 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 L 266 5x65 S6 F 71 N.S6.01
Hydrophobic ICL2 L 177 - S8 L 126 N.S8.03
Hydrophobic TM3 R 169 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 169 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 Q 279 6x22 S6 V 77 N.S6.07
Van-der-waals TM6 Q 279 6x22 S6 V 77 N.S6.07
Hydrophobic TM5 G 273 5x72 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 G 273 5x72 s17s18 L 311 C.s17s18.40
Hydrophobic TM6 T 290 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 R 180 - s5s6 L 64 N.s5s6.05
Van-der-waals ICL2 R 180 - s5s6 L 64 N.s5s6.05
Polar TM6 K 286 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 L 177 - S9 C 137 N.S9.01
Van-der-waals ICL2 L 177 - S9 C 137 N.S9.01
Hydrophobic TM2 I 110 2x43 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 I 110 2x43 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 S 104 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 P 179 - s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 P 179 - s17s18 R 282 C.s17s18.11
Polar ICL2 L 177 - S16 Y 246 C.S16.03
Hydrophobic ICL2 L 177 - S16 Y 246 C.S16.03
Van-der-waals ICL2 L 177 - S16 Y 246 C.S16.03
Hydrophobic TM5 M 271 5x70 S6 K 73 N.S6.03
Van-der-waals TM5 M 271 5x70 S6 K 73 N.S6.03
Polar TM6 T 290 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 290 6x33 s5s6 I 67 N.s5s6.08
Polar ICL2 P 176 - S5 Y 59 N.S5.12
Hydrophobic ICL2 P 176 - S5 Y 59 N.S5.12
Van-der-waals ICL2 P 176 - S5 Y 59 N.S5.12
Hydrophobic ICL3 E 278 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 E 278 - s9s10 E 152 N.s9s10.07
Hydrophobic TM3 I 173 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 173 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM7 L 348 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 L 348 7x56 s5s6 V 66 N.s5s6.07
Polar TM5 N 270 5x69 S6 K 73 N.S6.03
Van-der-waals TM5 N 270 5x69 S6 K 73 N.S6.03
Hydrophobic TM3 I 173 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 173 3x54 S6 F 71 N.S6.01
Polar TM5 K 265 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 K 265 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 K 265 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 L 294 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 I 272 5x71 s15s16 L 240 C.s15s16.02
Hydrophobic H8 N 349 8x47 s5s6 V 66 N.s5s6.07
Polar H8 N 351 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 351 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 I 173 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 173 3x54 s5s6 I 67 N.s5s6.08
Ionic ICL2 R 180 - s5s6 D 63 N.s5s6.04
Polar ICL2 R 180 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 180 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 180 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 180 - s5s6 G 60 N.s5s6.01
Hydrophobic ICL2 P 176 - s15s16 Y 241 C.s15s16.03
Polar ICL2 R 180 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 R 180 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 180 - s5s6 R 61 N.s5s6.02
Hydrophobic TM5 C 269 5x68 s15s16 Y 241 C.s15s16.03
Polar TM3 R 169 3x50 s5s6 V 66 N.s5s6.07
Ionic TM3 H 175 3x56 S16 D 244 C.S16.01
Polar TM3 H 175 3x56 S16 D 244 C.S16.01
Hydrophobic TM3 H 175 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 H 175 3x56 S16 D 244 C.S16.01
Polar ICL2 L 177 - S5 Y 59 N.S5.12
Hydrophobic ICL2 L 177 - S5 Y 59 N.S5.12
Van-der-waals ICL2 L 177 - S5 Y 59 N.S5.12
Hydrophobic TM7 L 348 7x56 s5s6 I 67 N.s5s6.08
Polar ICL2 L 177 - S16 D 244 C.S16.01
Hydrophobic ICL2 L 177 - S16 D 244 C.S16.01
Van-der-waals ICL2 L 177 - S16 D 244 C.S16.01
Hydrophobic TM5 I 272 5x71 s17s18 D 308 C.s17s18.37
Van-der-waals TM5 I 272 5x71 s17s18 D 308 C.s17s18.37
Hydrophobic TM5 I 272 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 I 272 5x71 s17s18 E 310 C.s17s18.39