S-arrestin - GPR83 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR83 70.0
S-arrestin 82.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL1 R 101 12x49 s20c R 398 C.s20c.17
Hydrophobic ICL1 R 101 12x49 s20c R 398 C.s20c.17
Van-der-waals ICL1 R 101 12x49 s20c R 398 C.s20c.17
Hydrophobic ICL2 P 176 - S5 Y 71 N.S5.12
Van-der-waals ICL2 P 176 - S5 Y 71 N.S5.12
Polar TM5 K 265 5x64 s15s16 Y 254 C.s15s16.03
Polar TM6 T 290 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 290 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 290 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 A 282 6x25 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 Q 279 6x22 S6 F 89 N.S6.07
Van-der-waals TM6 Q 279 6x22 S6 F 89 N.S6.07
Polar TM5 D 274 5x73 s7s8 Y 129 N.s7s8.05
Hydrophobic TM5 D 274 5x73 s7s8 Y 129 N.s7s8.05
Van-der-waals TM5 D 274 5x73 s7s8 Y 129 N.s7s8.05
Hydrophobic TM6 T 290 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 T 290 6x33 s5s6 L 81 N.s5s6.10
Polar TM3 R 169 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 169 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 169 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 G 273 5x72 S6 L 87 N.S6.05
Van-der-waals TM5 G 273 5x72 S6 L 87 N.S6.05
Hydrophobic TM5 I 272 5x71 s17s18 T 323 C.s17s18.39
Hydrophobic ICL3 V 275 - S6 D 86 N.S6.04
Van-der-waals ICL3 V 275 - S6 D 86 N.S6.04
Hydrophobic ICL3 T 276 - S6 F 89 N.S6.07
Van-der-waals ICL3 T 276 - S6 F 89 N.S6.07
Hydrophobic ICL1 H 103 12x51 s5s6 I 76 N.s5s6.05
Hydrophobic TM3 I 173 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 I 173 3x54 s5s6 I 79 N.s5s6.08
Polar ICL2 L 177 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 L 177 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 L 177 - s8s9 K 145 N.s8s9.09
Hydrophobic TM5 I 272 5x71 s15s16 L 253 C.s15s16.02
Ionic TM6 R 285 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 285 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 285 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM5 G 273 5x72 s17s18 V 324 C.s17s18.40
Hydrophobic TM7 L 348 7x56 s5s6 G 80 N.s5s6.09
Polar ICL2 R 180 - s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 R 180 - s5s6 Q 73 N.s5s6.02
Van-der-waals ICL2 R 180 - s5s6 Q 73 N.s5s6.02
Ionic H8 E 350 8x48 s9s10 K 170 N.s9s10.12
Hydrophobic TM7 L 348 7x56 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 L 348 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 173 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 173 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 177 - S15 V 251 C.S15.14
Ionic ICL1 R 101 12x49 s20c D 402 C.s20c.21
Hydrophobic TM3 R 169 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 V 275 - S6 L 87 N.S6.05
Hydrophobic TM5 I 272 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 I 272 5x71 S6 R 85 N.S6.03
Hydrophobic TM2 S 104 2x37 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 S 104 2x37 s5s6 I 76 N.s5s6.05
Polar TM5 D 274 5x73 S6 L 87 N.S6.05
Van-der-waals TM5 D 274 5x73 S6 L 87 N.S6.05
Hydrophobic TM3 V 172 3x53 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 P 176 - s15s16 Y 254 C.s15s16.03
Polar ICL2 R 180 - s8s9 G 144 N.s8s9.08
Hydrophobic TM5 I 272 5x71 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 I 272 5x71 s17s18 V 324 C.s17s18.40
Hydrophobic ICL1 M 102 12x50 s5s6 I 76 N.s5s6.05
Van-der-waals ICL1 M 102 12x50 s5s6 I 76 N.s5s6.05
Polar ICL3 E 278 - s9s10 A 163 N.s9s10.05
Hydrophobic ICL3 E 278 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 E 278 - s9s10 A 163 N.s9s10.05
Hydrophobic TM6 M 293 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 293 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 V 262 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 179 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 179 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 L 177 - S16 D 257 C.S16.01
Polar ICL2 L 177 - S16 Y 259 C.S16.03
Hydrophobic ICL2 L 177 - S16 Y 259 C.S16.03
Van-der-waals ICL2 L 177 - S16 Y 259 C.S16.03
Hydrophobic ICL2 R 180 - S6 F 83 N.S6.01
Hydrophobic ICL2 P 179 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 P 179 - s8s9 D 142 N.s8s9.06
Polar TM6 Q 279 6x22 S6 D 86 N.S6.04
Van-der-waals TM6 Q 279 6x22 S6 D 86 N.S6.04
Ionic TM6 K 286 6x29 s9s10 D 166 N.s9s10.08
Polar TM6 K 286 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 K 286 6x29 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 K 286 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 K 178 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 K 178 - s8s9 K 145 N.s8s9.09
Polar TM5 D 274 5x73 S6 Y 88 N.S6.06
Hydrophobic TM5 D 274 5x73 S6 Y 88 N.S6.06
Van-der-waals TM5 D 274 5x73 S6 Y 88 N.S6.06
Hydrophobic ICL2 L 177 - S9 C 147 N.S9.01
Van-der-waals ICL2 L 177 - S9 C 147 N.S9.01
Polar TM5 D 274 5x73 S6 F 89 N.S6.07
Polar H8 N 349 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 349 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 349 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 L 294 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 294 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 V 172 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 V 172 3x53 S6 F 83 N.S6.01
Hydrophobic TM3 I 173 3x54 S6 F 83 N.S6.01
Polar H8 E 350 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 E 350 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 L 266 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 266 5x65 s5s6 L 81 N.s5s6.10